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Oncogenic Transformation by the Signaling Adaptor Proteins Insulin Receptor Substrate (IRS)-1 and IRS-2
Open accessAbstract
Insulin receptor substrates (IRSs) are adaptor proteins that link signaling from upstream activators to multiple downstream effectors to modulate normal growth, metabolism, survival, and differentiation. Recent cell culture studies have shown that IRSs can interact with, and are functionally required for, the transforming ability of many oncogenes. Consistent with this, IRSs are elevated and hyperactive in many human tumors. IRSs respond to many extracellular signals that are critical for mammary gland development, and we have shown that IRSs disrupt normal mammary acini formation in vitro, and cause mammary tumorigenesis and metastasis in vivo. In this review we will discuss the role of IRSs in both transformation and cancer progression.
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Cited by
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Beroukhim, R., Mermel, C. H., Porter, D., Wei, G., Raychaudhuri, S., Donovan, J., Barretina, J., Boehm, J. S., Dobson, J., Urashima, M., et al. (2010) · Nature · doi:10.1038/nature08822 · Cited by 4,017
Neutrophil elastase–mediated degradation of IRS-1 accelerates lung tumor growth
Houghton, A. M., Rzymkiewicz, D. M., Ji, H., Gregory, A. D., Egea, E. E., Metz, H. E., Stolz, D. B., Land, S. R., Marconcini, L. A., Kliment, C. R., et al. (2010) · Nature Medicine · doi:10.1038/nm.2084 · Cited by 744
Carter, H., Chen, S., Isik, L., Tyekucheva, S., Velculescu, V. E., Kinzler, K. W., Vogelstein, B., & Karchin, R. (2009) · Cancer Research · doi:10.1158/0008-5472.can-09-1133 · Cited by 458
Lai, D., Ho, K. C., Hao, Y., & Yang, X. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-2711 · Cited by 416
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Metadata
- Authors
- Dearth, R. K., Cui, X., Kim, H.-J., Hadsell, D. L., & Lee, A. V.
- Venue
- Cell Cycle
- Publisher
- Informa UK Limited
- Published
- 2007-03-15
- Volume
- 6
- Issue
- 6
- Pages
- 705-713
- ISSN
- 1538-4101 (ISSN-L)
- 1551-4005
- OpenAlex
- W2010223438
- Cited by
- 167
- References
- 0
- FWCI
- 5.03
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: Oncogenic Transformation by the Signaling Adaptor Proteins Insulin Receptor Substrate (IRS)-1 and IRS-2. https://app.cochat.ai/papers/10.4161/cc.6.6.4035
- The paper
- Dearth, R. K., Cui, X., Kim, H.-J., Hadsell, D. L., & Lee, A. V. (2007). Oncogenic Transformation by the Signaling Adaptor Proteins Insulin Receptor Substrate (IRS)-1 and IRS-2. Cell Cycle. https://doi.org/10.4161/cc.6.6.4035
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