Direct role of nucleotide metabolism in C-MYC-dependent proliferation of melanoma cells

Mannava, Sudha, Grachtchouk, Vladimir, Wheeler, Linda J., Im, Michael, Zhuang, Dazhong, Slavina, Elena G., Mathews, Christopher K., Shewach, Donna S., Nikiforov, Mikhail A.·2008·Cell Cycle

DOI 10.4161/cc.6390

Cited by (266)

Items 101–200 of 266

MYC sensitises cells to apoptosis by driving energetic demand
Joy Edwards-Hicks, Huizhong Su, Maurizio Mangolini, Kubra Karaosmanoglu Yoneten, Jimi C. Wills, Giovanny Rodriguez Blanco, Christine S. Young, Kevin Cho, Heather S. Barker, Morwenna Muir et al. · 2022 · Nature Communications
Regulation of PI3K signaling in cancer metabolism and PI3K-targeting therapy
Beinan Han, Xiaorong Lin, Hai Hu · 2024 · Translational Breast Cancer Research
PP2A-B56α controls oncogene-induced senescence in normal and tumor human melanocytic cells
Sudha Mannava, Angela R. Omilian, Joseph A. Wawrzyniak, Emily E. Fink, D. Zhuang, Jeffrey C. Miecznikowski, James Roger Marshall, Marı́a S. Soengas, Rosalie C. Sears, Carl Morrison et al. · 2011 · Oncogene
MYC-Induced Replicative Stress: A Double-Edged Sword for Cancer Development and Treatment
Laura Curti, Stefano Campaner · 2021 · International Journal of Molecular Sciences
SARS-CoV-2 couples evasion of inflammatory response to activated nucleotide synthesis
Chao Qin, Youliang Rao, Hao Yuan, Tingyu Wang, Jun Zhao, Bianca Espinosa, Yongzhen Liu, Shu Jie Zhang, Ali Can Savas, Qizhi Liu et al. · 2022 · Proceedings of the National Academy of Sciences
A journey into the regulatory secrets of the de novo purine nucleotide biosynthesis
Nour Ayoub, Antoine Gedeon, Hélène Munier‐Lehmann · 2024 · Frontiers in Pharmacology
Pan‐cancer RNA‐seq data stratifies tumours by some hallmarks of cancer
F. Graeme Frost, Praveen F. Cherukuri, Samuel J. Milanovich, Cornelius F. Boerkoel · 2019 · Journal of Cellular and Molecular Medicine
Targeting the De Novo Purine Synthesis Pathway Through Adenylosuccinate Lyase Depletion Impairs Liver Cancer Growth by Perturbing Mitochondrial Function
Tingting Jiang, Francisco J. Sánchez Rivera, Yadira M. Soto‐Feliciano, Qiyuan Yang, Chun‐Qing Song, Arjun Bhuatkar, Cole M. Haynes, Michael T. Hemann, Wen Xue · 2020 · Hepatology
Mechanisms Governing Metabolic Heterogeneity in Breast Cancer and Other Tumors
Sayani Patra, Naveed Elahi, Aaron Armorer, Swathi Arunachalam, Joshua Omala, Iman Hamid, Anthony W. Ashton, David A. Joyce, Xuanmao Jiao, Richard G. Pestell · 2021 · Frontiers in Oncology
Regulation of local GTP availability controls RAC1 activity and cell invasion
Anna Bianchi, David W. Wolff, Daniel J. Marston, Zhiyong Deng, Zhannan Han, Sudha Moparthy, Rebecca M. Wombacher, Ashley L. Mussell, Shichen Shen, Jialin Chen et al. · 2021 · Nature Communications
Metabolic Roles of HIF1, c-Myc, and p53 in Glioma Cells
Cristina Trejo‐Solís, Rosa Angélica Castillo‐Rodríguez, Norma Serrano-García, Daniela Silva‐Adaya, Salvador Vargas-Cruz, Elda Georgina Chávez-Cortéz, Juan Carlos Gallardo‐Pérez, Sergio Zavala-Vega, Arturo Cruz-Salgado, Roxana Magaña-Maldonado · 2024 · Metabolites
MYCN promotes neuroblastoma malignancy by establishing a regulatory circuit with transcription factor AP4
Chengyuan Xue, Denise Ming Tse Yu, Samuele Gherardi, Jessica Koach, Giorgio Milazzo, Laura D. Gamble, Bing Liu, Emanuele Valli, Amanda J. Russell, Wendy B. London et al. · 2016 · Oncotarget
MYC, Metabolic Synthetic Lethality, and Cancer
Annie Lee Hsieh, Chi Van Dang · 2016 · Recent results in cancer research/Recent Results in Cancer Research
Targeting MYC Dependence by Metabolic Inhibitors in Cancer
Himalee S. Sabnis, Ranganatha R. Somasagara, Kevin D. Bunting · 2017 · Genes
Nucleotide depletion reveals the impaired ribosome biogenesis checkpoint as a barrier against DNA damage
Joffrey Pelletier, Ferran Riaño‐Canalias, Eugènia Almacellas, Caroline Mauvezin, Sara Samino, Sònia Feu, Sandra Menoyo, Ana Domostegui, Marta Garcia‐Cajide, Ramón Salazar et al. · 2020 · The EMBO Journal
Unraveling the mystery of cancer metabolism in the genesis of tumor-initiating cells and development of cancer
Gaochuan Zhang, Ping Yang, Peng-Da Guo, Lucio Miele, Fazlul H. Sarkar, Zhiwei Peter Wang, Quansheng Zhou · 2013 · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
Risks at the DNA Replication Fork: Effects upon Carcinogenesis and Tumor Heterogeneity
Tony M. Mertz, Victoria Harcy, Steven A. Roberts · 2017 · Genes
Targeting snoRNAs as an emerging method of therapeutic development for cancer.
Di Zhang, Juan Zhou, Jie Gao, Ri-Ying Wu, Yinglong Huang, Qinwen Jin, Jiansi Chen, Weizhong Tang, Lin‐Hai Yan · 2019 · PubMed Central
Ribonucleotide reductase and thymidylate synthase or exogenous deoxyribonucleosides reduce DNA damage and senescence caused by C-MYC depletion
Sudha Mannava, Kalyana Moparthy, Linda J. Wheeler, Katerina I. Leonova, Joseph A. Wawrzyniak, Anna Bianchi, A. E. Berman, Sheryl A. Flanagan, Donna S. Shewach, Nathalie C. Zeitouni et al. · 2012 · Aging
Growth-promoting and tumourigenic activity of c-Myc is suppressed by Hhex
Vanessa Marfil, Marina Blazquez, F Serrano, José Vicente Castell, Roque Bort · 2014 · Oncogene
Dysregulated Pyrimidine Biosynthesis Contributes to 5-FU Resistance in SCLC Patient-Derived Organoids but Response to a Novel Polymeric Fluoropyrimidine, CF10
William H. Gmeiner, Lance David Miller, Jeff W. Chou, Anthony J. Dominijanni, Lysette A. Mutkus, Frank C. Marini, Jimmy Ruiz, Travis L. Dotson, Karl W. Thomas, Graham E. Parks et al. · 2020 · Cancers
Understanding the interplay between dNTP metabolism and genome stability in cancer
Miriam Yagüe-Capilla, Sean G. Rudd · 2024 · Disease Models & Mechanisms
PRPS2 Expression Correlates with Sertoli-Cell Only Syndrome and Inhibits the Apoptosis of TM4 Sertoli Cells
Bin Lei, Bo Wan, Jian Wei Peng, Yu Yang, Daojun Lv, Xuming Zhou, Fangpeng Shu, Fei Li, Liren Zhong, Huayan Wu et al. · 2015 · The Journal of Urology
Polη, a Y-family translesion synthesis polymerase, promotes cellular tolerance of Myc-induced replication stress
Kiminori Kurashima, Takayuki Sekimoto, Tsukasa Oda, Tsuyoshi Kawabata, Fumio Hanaoka, Takayuki Yamashita · 2018 · Journal of Cell Science
Emerging Concepts in the Analysis of Transcriptional Targets of the MYC Oncoprotein: Are the Targets Targetable?
S. B. McMahon · 2010 · Genes & Cancer
Pharmacokinetic and Pharmacodynamic Factors Contribute to Synergism between Let-7c-5p and 5-Fluorouracil in Inhibiting Hepatocellular Carcinoma Cell Viability
Joseph Lionel Jilek, Mei‐Juan Tu, Chao Zhang, Ai‐Ming Yu · 2020 · Drug Metabolism and Disposition
Compartmentalization and regulation of GTP in control of cellular phenotypes
David W. Wolff, Anna Bianchi, Mikhail A. Nikiforov · 2022 · Trends in Molecular Medicine
Spatial transcriptome and single-cell reveal the role of nucleotide metabolism in colorectal cancer progression and tumor microenvironment
Junzhi Liu, Huimin Li, Lantian Wang, Shurui Wang, Qiang Tang · 2024 · Journal of Translational Medicine
SARS-CoV-2 Nsp14 protein associates with IMPDH2 and activates NF-κB signaling
Tai-Wei Li, Adam D. Kenney, Jun‐Gyu Park, Guillaume N. Fiches, Helu Liu, Dawei Zhou, Ayan Biswas, Weiqiang Zhao, Jianwen Que, Netty G. Santoso et al. · 2022 · Frontiers in Immunology
c-Myc plays a key role in IFN-γ-induced persistence of Chlamydia trachomatis
Nadine Vollmuth, Lisa Schlicker, Yongxia Guo, Pargev Hovhannisyan, Sudha Janaki‐Raman, Naziia Kurmasheva, Werner Schmitz, Almut Schulze, Kathrin Stelzner, Karthika Rajeeve et al. · 2022 · eLife
FOXK2 affects cancer cell response to chemotherapy by promoting nucleotide de novo synthesis
Yingge Li, Jie Chen, Bin Wang, Ziwen Xu, Ci Wu, Junfeng Ma, Qibin Song, Qing Geng, Jinming Yu, Huadong Pei et al. · 2023 · Drug Resistance Updates
MYC Induces Oncogenic Stress through RNA Decay and Ribonucleotide Catabolism in Breast Cancer
Jitendra Kumar Meena, Jarey H. Wang, Nicholas J. Neill, Dianne T. Keough, Nagireddy Putluri, Panagiotis Katsonis, Amanda M. Koire, Hyemin Lee, Elizabeth A. Bowling, Siddhartha Tyagi et al. · 2024 · Cancer Discovery
Glucose metabolism and its direct action in cancer and immune regulation: opportunities and challenges for metabolic targeting
Bo‐Syong Pan, Che-Chia Hsu, Hsin‐En Wu, Yuan-Ru Chen, Xiaobo Zhou, Shu‐Chi Wang, Chia‐Yang Li, Hui-Kuan Lin · 2025 · Journal of Biomedical Science
Recent progress in genetics of aging, senescence and longevity: focusing on cancer-related genes
A. E. Berman, Olga V. Leontieva, Venkatesh Natarajan, James Andrew McCubrey, Zoya N. Demidenko, Mikhail A. Nikiforov · 2012 · Oncotarget
Phosphoribosyl pyrophosphate synthetases 2 knockdown inhibits prostate cancer progression by suppressing cell cycle and inducing cell apoptosis
Hui Qiao, Xiao Tan, Daojun Lv, Rongwei Xing, Fangpeng Shu, Chuanfan Zhong, Chun Li, Ya-guang Zou, Xiangming Mao · 2019 · Journal of Cancer
Cyclin-Dependent Kinase Synthetic Lethality Partners in DNA Damage Response
Mateusz Kciuk, Adrianna Gielecińska, Somdutt Mujwar, Mariusz Mojzych, Renata Kontek · 2022 · International Journal of Molecular Sciences
Point Mutations in c-Myc Uncouple Neoplastic Transformation from Multiple Other Phenotypes in Rat Fibroblasts
J. Anthony Graves, Kristi D. Rothermund, Tao Wang, Wei Qian, Bennett Van Houten, Edward V. Prochownik · 2010 · PLoS ONE
The Role of Non-Coding RNAs in the Regulation of the Proto-Oncogene MYC in Different Types of Cancer
Ekaterina M. Stasevich, Matvey Mikhailovich Murashko, L. S. Zinevich, Д. Э. Демин, A. M. Schwartz · 2021 · Biomedicines
c‐Myc–IMPDH1/2 axis promotes tumourigenesis by regulating GTP metabolic reprogramming
Qiang Zhang, Kaisa Cui, Xiaoya Yang, Qilang He, Jing Yu, Li Chun Yang, Gang Yao, Weiwei Guo, Zhanhao Luo, Yugeng Liu et al. · 2023 · Clinical and Translational Medicine
PAICS as a potential target for cancer therapy linking purine biosynthesis to cancer progression
A. Huo Ma, Xiangyang Xiong · 2023 · Life Sciences
Probing the Active Site of the Deoxynucleotide N-Hydrolase Rcl Encoded by the Rat Gene c6orf108
Christelle Dupouy, Chi Zhang, André Padilla, Sylvie Pochet, Pierre Alexandre Kaminski · 2010 · Journal of Biological Chemistry
Impact of MYC on Anti-Tumor Immune Responses in Aggressive B Cell Non-Hodgkin Lymphomas: Consequences for Cancer Immunotherapy
A. Vera de Jonge, Tuna Mutis, Margaretha G.M. Roemer, Blanca Scheijen, Martine E.D. Chamuleau · 2020 · Cancers
IMPDH2 promotes cell proliferation and epithelial‑mesenchymal transition of non‑small cell lung cancer by activating the Wnt/β‑catenin signaling pathway
Hao Xu, Hongda Ma, Lifen Zha, Qian Li, Guanghui Yang, Huiming Pan, Xiangping Fei, Xingxiang Xu, Xing Chen, Ladi Zhang · 2020 · Oncology Letters
Effect of small interfering RNA 3'-end overhangs on chemosensitivity to thymidylate synthase inhibitors
John C. Schmitz, Edward Chu · 2011 · Silence
The role of dNTP metabolites in control of the embryonic cell cycle
Boyang Liu, Jörg Großhans · 2019 · Cell Cycle
Contribution of Model Organisms to Investigating the Far-Reaching Consequences of PRPP Metabolism on Human Health and Well-Being
Eziuche Amadike Ugbogu, Lilian Mary Schweizer, Michael Schweizer · 2022 · Cells
Genistein promotes apoptosis of lung cancer cells through the IMPDH2/AKT1 pathway.
Hao Xu, Hongda Ma, Lifen Zha, Qian Li, Huiming Pan, Ladi Zhang · 2022 · PubMed Central
Targeted Quantitative Kinome Analysis Identifies PRPS2 as a Promoter for Colorectal Cancer Metastasis
Weili Miao, Yinsheng Wang · 2019 · Journal of Proteome Research
SARS-CoV-2 Nsp14 activates NF-κB signaling and induces IL-8 upregulation
Tai-Wei Li, Adam D. Kenney, Helu Liu, Guillaume N. Fiches, Dawei Zhou, Ayan Biswas, Jianwen Que, Netty G. Santoso, Jacob S. Yount, Jian Kang Zhu · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
CD147‑mediated reprogrammed glycolytic metabolism potentially induces immune escape in the tumor microenvironment (Review)
Xiaofeng Li, Wengui Xu · 2019 · Oncology Reports
PRPS2 enhances RNA m6A methylation by stimulating SAM synthesis through enzyme-dependent and independent mechanisms
Lin Zhang, Xian Zhao, Jingyan Hu, Tingting Li, Hongzhuan Chen, Ao Zhang, Hao Wang, Jianxiu Yu, Liang Zhang · 2025 · Nature Communications
Phosphoribosyl-pyrophosphate synthetase 2 (PRPS2) depletion regulates spermatogenic cell apoptosis and is correlated with hypospermatogenesis
Xiangming Mao, Fangpeng Shu, Bin Lei, Lixia Xie, Shou‐Bo Zhang, Bo Wan, Liren Zhong, Xuming Zhou · 2019 · Asian Journal of Andrology
Metabolomic Study on Nude Mice Models of Gastric Cancer Treated with Modified Si Jun Zi Tang via HILIC UHPLC-Q-TOF/MS Analysis
Shanshan Nie, Yuhang Zhao, Xinjian Qiu, Wenbo Wang, Ye Yao, Min Yi, Dongsheng Wang · 2019 · Evidence-based Complementary and Alternative Medicine
Down-Regulation of Phosphoribosyl Pyrophosphate Synthetase 1 Inhibits Neuroblastoma Cell Proliferation
Jifu Li, Junhong Ye, Shunqin Zhu, Hongjuan Cui · 2019 · Cells
Mechanisms by Which Metabolic Reprogramming in GSD1 Liver Generates a Favorable Tumorigenic Environment
Monika Gjorgjieva, Maaike H. Oosterveer, Gilles Mithieux, Fabienne Rajas · 2016 · Journal of Inborn Errors of Metabolism and Screening
LncRNA UCA1 Participates in De Novo Synthesis of Guanine Nucleotides in Bladder Cancer by Recruiting TWIST1 to Increase IMPDH1/2
Shanshan Liu, Jiashu Li, Mei Xue, Wenjing Wu, Li Xu, Wei Chen · 2023 · International Journal of Biological Sciences
Mining the key regulatory genes of chicken inosine 5′-monophosphate metabolism based on time series microarray data
Teng Ma, Lu Xu, Hongzhi Wang, Jing Chen, Lu Liu, Guobin Chang, Guohong Chen · 2015 · Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology
Reducing MYC's transcriptional footprint unveils a good prognostic gene signature in melanoma
Mariano F. Zacarías Fluck, Daniel Massó-Vallés, Fabio Giuntini, Íñigo González-Larreategui, Jastrinjan Kaur, Sílvia Casacuberta‐Serra, Toni Jauset, Sandra Martínez-Martín, Génesis Martín-Fernández, Erika Serrano del Pozo et al. · 2023 · Genes & Development
Humanized TLR7/8 Expression Drives Proliferative Multisystemic Histiocytosis in C57BL/6 Mice
Jessica M. Snyder, Piper M. Treuting, Lee Nagy, Cathy S. Yam, Jaehun Yi, Alicia Brasfield, Lisa Nguyen, Adeline M. Hajjar · 2014 · PLoS ONE
Phosphorylation of guanosine monophosphate reductase triggers a GTP-dependent switch from pro- to anti-oncogenic function of EPHA4
David W. Wolff, Zhiyong Deng, Anna Bianchi, C E Foley, Zhannan Han, Xingyou Wang, Shichen Shen, Masha M. Rosenberg, Sudha Moparthy, Dong Hyun Yun et al. · 2022 · Cell chemical biology
Lessons in aging from Myc knockout mouse models
Edward V. Prochownik, Huabo Wang · 2023 · Frontiers in Cell and Developmental Biology
Inosine monophosphate dehydrogenase 2 (IMPDH2) modulates response to therapy and chemo-resistance in triple negative breast cancer
Tatiane da Silva Fernandes, Bryan M. Gillard, Tao Dai, Jeffrey C. Martin, Kanita A. Chaudhry, Scott M. Dugas, Alyssa A. Fisher, Pia I. Sharma, Rongrong Wu, Kristopher M. Attwood et al. · 2025 · Scientific Reports
Revisiting β‐Catenin Signaling in T‐Cell Development and T‐Cell Acute Lymphoblastic Leukemia
Anna Bigas, Yolanda Guillén, Leonie Schoch, David Arambilet · 2019 · BioEssays
Chapter 12 Liposome-Mediated Therapy of Neuroblastoma
Daniela Di Paolo, Monica Loi, Fabio Pastorino, Chiara Brignole, Danilo Marimpietri, Pamela Becherini, Irene Caffa, Alessia Zorzoli, Renato Longhi, Maria Cristina Gagliani et al. · 2009 · Methods in enzymology on CD-ROM/Methods in enzymology
Role of PRPS2 as a prognostic and therapeutic target in osteosarcoma
Yanli Luo, Junqing Yuan, Jin Huang, Tingting Yang, Jun Zhou, Tang Juan, Min Liu, Jie Chen, Chunyan Chen, Wentao Huang et al. · 2021 · Journal of Clinical Pathology
MYC/Glutamine Dependency Is a Therapeutic Vulnerability in Pancreatic Cancer with Deoxycytidine Kinase Inactivation-Induced Gemcitabine Resistance
Suman Dash, Takeshi Ueda, Akiyoshi Komuro, Hisayuki Amano, Masahiko Honda, Masahito Kawazu, Hitoshi Okada · 2023 · Molecular Cancer Research
Recent advances in nanomedicine for metabolism-targeted cancer therapy
Jun Da, Xinjia Di, Yuqi Xie, Jili Li, Lili Zhang, Yanlan Liu · 2024 · Chemical Communications
Purinosomes involved in the regulation of tumor metabolism: current progress and potential application targets
Jiaqi Xie, Jiaqi Liu, Xiehui Chen, Changchun Zeng · 2024 · Frontiers in Oncology
Towards Understanding PRPS1 as a Molecular Player in Immune Response in Yellow Drum (Nibea albiflora)
Qianqian Tian, Wanbo Li, Jiacheng Li, Yao Xiao, Baolan Wu, Zhiyong Wang, Fang Han · 2022 · International Journal of Molecular Sciences
Single-cell RNA sequencing in double-hit lymphoma: IMPDH2 induces the progression of lymphoma by activating the PI3K/AKT/mTOR signaling pathway
Guangcan Gao, Qingfeng Xue, Jing He, Meng Wu, Yongning Jiang, Quanqing Li, Yaping Zhang, Wenyu Shi · 2023 · International Immunopharmacology
Molecular mechanism of c‐Myc and PRPS1/2 against thiopurine resistance in Burkitt's lymphoma
Ting Li, Lili Song, Yingwen Zhang, Yali Han, Zhiyan Zhan, Zhou Xv, Yang Li, Yi Yang, Siqi Wang, Siqi wang et al. · 2020 · Journal of Cellular and Molecular Medicine
Nucleotide salvage, genome instability, and potential therapeutic applications
Pengcheng Wang, Chen Wang, Yinsheng Wang · 2026 · Nucleic Acids Research
The oncogenic control of nucleotide synthesis
Olivia Vidal-Cruchez, Issam Ben‐Sahra · 2026 · Oncogenesis
MicroRNA‑27b inhibits the development of melanoma by targeting MYC
Yi Tian, Juanni Zeng, Zongliang Yang · 2021 · Oncology Letters
Paying “Particle” Attention to Novel Melanoma Treatment Strategies
Michele B. Weiss, Andrew E. Aplin · 2010 · Journal of Investigative Dermatology
Control of nucleotide biosynthesis by the MYC oncoprotein.
Steven B. McMahon · 2008 · PubMed
The role of metabolic reprogramming in kidney cancer
Ziyi Chen, Xiaohong Zhang · 2024 · Frontiers in Oncology
Viral Reprogramming of Nucleotide Synthesis and Its Impact on Viral Infection
Lara Dsouza, Zhilong Yang · 2025 · Journal of Medical Virology
Polycomb EZH1 regulates cell cycle/5‐fluorouracil sensitivity of neuroblastoma cells in concert with MYCN
Yoshitaka Shinno, Hisanori Takenobu, Ryuichi P. Sugino, Yuki Endo, Ryu Okada, Masayuki Haruta, Shunpei Satoh, Kyosuke Mukae, Dilibaerguli Shaliman, Tomoko Wada et al. · 2022 · Cancer Science
Growth Transformation of B Cells by Epstein-Barr Virus Requires IMPDH2 Induction and Nucleolar Hypertrophy
Atsuko Sugimoto, Takahiro Watanabe, Kazuhiro Matsuoka, Yusuke Okuno, Yusuke Yanagi, Yohei Narita, Seiyo Mabuchi, Hiroyuki Nobusue, Eiji Sugihara, Masaya Hirayama et al. · 2023 · Microbiology Spectrum
Vitexicarpin suppresses malignant progression of colorectal cancer through affecting c-Myc ubiquitination by targeting IMPDH2
Xiaojing Ding, Xue-Mei Cai, Qianqian Wang, Ning Liu, Weilong Zhong, Xiaonan Xi, Yaxin Lu · 2024 · Phytomedicine
Kinase Suppressor of RAS 1 (KSR1) Maintains the Transformed Phenotype of BRAFV600E Mutant Human Melanoma Cells
Zhi Liu, Aleksandar Krstić, Ashish Neve, Cristina Casalou, Nora Rauch, Kieran J. Wynne, Hilary Cassidy, Amanda H McCann, Emma L. Kavanagh, Brendan McCann et al. · 2023 · International Journal of Molecular Sciences
The Immortal Senescence
Anna Bianchi, Brittany C. Lipchick, Mikhail A. Nikiforov · 2016 · Methods in molecular biology
Oncogenic Control of Metabolism
Natalya N. Pavlova, Craig B. Thompson · 2024 · Cold Spring Harbor Perspectives in Medicine
Serum lncRNA PVT1 and Its Targets miR‐146a and SIRT1 as Biomarkers for the Early Detection of Breast Cancer and Its Metastasis
Noha H. Sayed, Mahmoud Ahmed Senousy, Olfat Gamil Shaker, Mona A. Kortam · 2025 · Biotechnology and Applied Biochemistry
CD133 Is Not Suitable Marker for Isolating Melanoma Stem Cells from D10 Cell Line.
Motahareh Rajabi Fomeshi, Marzieh Ebrahimi, Seyed Javad Mowla, Javad Firouzi, Pardis Khosravani · 2016 · Europe PMC (PubMed Central)
Zwint facilitates melanoma progression by promoting c‑Myc expression
Kuanhou Mou, Jian Zhang, Xin Ni Mu, Lijuan Wang, Wenli Liu, Rui Ge · 2021 · Experimental and Therapeutic Medicine
Association between bivariate expression of key oncogenes and metabolic phenotypes of patients with prostate cancer
Elham Khodayari Moez, Saumyadipta Pyne, Irina A Dinu · 2018 · Computers in Biology and Medicine
Knockdown of DEAD-box RNA helicase 52 (DDX52) suppresses the proliferation of melanoma cells in vitro and of nude mouse xenografts by targeting c-Myc
Qiang Wang, Leqi Qian, Mengyuan Tao, Jiaqi Liu, Fazhi Qi · 2021 · Bioengineered
Metabolic Control by DNA Tumor Virus-Encoded Proteins
Martin A. Prusinkiewicz, Joe S. Mymryk · 2021 · Pathogens
Expression of phosphoribosyl pyrophosphate synthetase genes in U87 glioma cells with ERN1 knockdown: effect of hypoxia and endoplasmic reticulum stress
О. H. Minchenko · 2014 · The Ukrainian Biochemical Journal
Differences in glucose concentration shows new perspectives in gastric cancer metabolism
Emerson Lucena da Silva, Felipe Pantoja Mesquita, Adrhyann Jullyanne de Sousa Portilho, Emanuel Cintra Austregésilo Bezerra, Júlio Paulino Daniel, Elenn Suzany Pereira Aranha, Sarah H. Farran, Marne Carvalho de Vasconcellos, Maria Elisabete Amaral de Moraes, Caroline Aquino Moreira-Nunes et al. · 2022 · Toxicology in Vitro
SHMT2 is essential for mammalian preimplantation embryonic development through de novo biosynthesis of nucleotide metabolites
Mingze Shi, Yingxue Huai, Tiantian Deng, Chuanxin Zhang, Jinzhu Song, Jiawei Wang, Yiwen Zhang, Zi‐Jiang Chen, Han Zhao, Keliang Wu et al. · 2025 · Molecular Therapy — Nucleic Acids
Pan-cancer analysis of pyrimidine metabolism reveals signaling pathways connections with chemoresistance role
Vignesh Ramesh, Mert Demirdizen, Luisa Pinna, Thomas Koed Doktor, Federica Benso, Aarif Siddiqui, Paolo Ceppi · 2025 · British Journal of Cancer
MUC-king with HIF May Rewire Pyrimidine Biosynthesis and Curb Gemcitabine Resistance in Pancreatic Cancer
Chi Van Dang · 2017 · Cancer Cell
Perturbation of nucleotide metabolism - the driving force of oncogene-induced senescence
Zbigniew Darżynkiewicz · 2013 · Oncotarget
Dehydroabietylamine exerts antitumor effects by affecting nucleotide metabolism in gastric cancer
Jingsong Ma, Jiabao Zhao, Zhengxin Wu, Jinshui Tan, Meijuan Xu, Wenjie Ye, Mengya Zhong, Yubo Xiong, Guangchao Pan, Huiwen Zhou et al. · 2024 · Carcinogenesis
Host protein PRPS2 interact with the non-structural protein p17 of Avian Reovirus and promote viral replication
Xiaomiao Hu, Ruihong Zhao, Li Wei, Pan Xiaocheng, Dai Yin, Huimin Wu, Yantao Wu, Zhang Chengcheng · 2024 · Poultry Science
Metabolomic and gene networks approaches reveal the role of mitochondrial membrane proteins in response of human melanoma cells to THz radiation
Е. А. Бутикова, Nikita V. Basov, Artem D. Rogachev, Evgeniy V. Gaisler, В. А. Иванисенко, Деменков Павел Сергеевич, Aelita-Luiza A. Makarova, Timofey Ivanisenko, И. А. Разумов, Daria A Kolomeyets et al. · 2025 · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
Impaired DNA damage responses and inflammatory signaling underpin hematopoietic stem cell defects in Gata2 haploinsufficiency
Ali Abdelfattah, Ahmad Habib, Leigh-anne Thomas, Juan Bautista Menendez-Gonzalez, Alhomidi Almotiri, Hind Alqahtani, Hannah Lawson, Sarab Taha, Millie Steadman, Radhika Athalye et al. · 2025 · Stem Cell Reports