The antidiabetic drug metformin suppresses HER2 (erbB-2) oncoprotein overexpression via inhibition of the mTOR effector p70S6K1 in human breast carcinoma cells

Vazquez-Martin, Alejandro, Oliveras-Ferraros, Cristina, Menendez, Javier A.·2009·Cell Cycle
DOI 10.4161/cc.8.1.7499

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  11. Metformin: Its salutary effects beyond diabetes mellitus
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  12. Is it the time for metformin to take place in adjuvant treatment of Her-2 positive breast cancer? Teaching new tricks to old dogs
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    M. A. Osipov, T. U. Semiglazova, Петр Владимирович Криворотько, V. V. Klimenko, Vladimir Kostorov, В. В. Семиглазов, Evgenia V. Tsyrlina, Irina G. Popovich, V. N. Anisimov, Владимир Федорович Семиглазов et al. · 2017 · Malignant tumours
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  17. Metforminin Melanom Cilt Kanseri Hücreleri Üzerindeki Etkisinin Araştırılması
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  18. Neratinib and metformin: A novel therapeutic approach against HER2-Positive Breast Cancer
    Hadeel Kheraldine, Arij Fouzat Hassan, Sumayyah Saeed · 2025 · Biomedicine & Pharmacotherapy
  19. Role of metformin in the treatment of malignant tumors
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  20. Adiponectin-Based Therapeutics for Cancer Treatment
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    Björn L.D.M. Brücher, Ijaz S. Jamall · 2019 · 4open
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  25. The Role of AMPK in Viral Infection
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  26. Determining the Role of Autophagy in HER2/neu-Induced Mammary Tumor Dormancy and Recurrence
    Samantha Dwyer · 2013 · Scholarly Commons (University of Pennsylvania)
  27. Diabetes, Insulin Resistance, and Cancer: An Update
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  28. Metformin: a pharmacological approach integrating hyperinsulinemia breast cáncer at the molecular, cellular clinical levels
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  33. Metformin and Cancer: past, present, future
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  34. Characterization and targeting of metabolic alterations in the leukemic microenvironment
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  35. Metformin and Prostate Cancer among Diabetic Men
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  36. Metformine — a new drug for the prevention and treatment of human malignant tumors
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  37. Regulation and Repair of Neural Stem Cells and the Neurogenic Niche
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  38. Metformin: Hype or Hope for Cancer
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  41. The role of mTOR signalling in translational control and cancer
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  42. References
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  43. Current World Literature
    2010 · Current Opinion in Endocrinology Diabetes and Obesity
  44. Metformin prevents morphine-induced apoptosis in rats with diabetic neuropathy: a possible mechanism for attenuating morphine tolerance
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  46. Data from Metformin and Other Biguanides in Oncology: Advancing the Research Agenda
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  47. Is physical inactivity and sedentary behavior associated with tumor stage in breast cancer patients? A cross-sectional study of Brazilian women
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  48. WBP2 Attenuates Metformin Response in HER2-Positive Breast Cancer Cells by Repressing AMPK Activation and Inducing a Lower AMP:ATP Ratio State Through Enhanced ATP Production
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  49. Metformin exhibits a synergistic effect with pyrotinib by inducing ferroptosis in HER2-positive cancers through the Keap1/Nrf2 pathway
    Yan Yang, Gaixian Shan, Huilin Li et al. · 2026 · Acta Biochimica et Biophysica Sinica
  50. A Framework for the Multilevel Integration of Molecular, Clinical, and Population Data in the Context of Breast Cancer: Challenges and Considerations of Socioecological Conditions and Pharmacogenomics
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