DDB2 (damaged-DNA binding protein 2) in nucleotide excision repair and DNA damage response
Open accessAbstract
DDB2 was identified as a protein involved in the Nucleotide Excision Repair (NER), a major DNA repair mechanism that repairs UV damage to prevent accumulation of mutations and tumorigenesis. However, recent studies indicated additional functions of DDB2 in the DNA damage response pathway. Herein, we discuss the proposed mechanisms by which DDB2 activates NER and programmed cell death upon DNA damage through its E3 ligase activity.
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DDB2 is a cellular fate determinant after DNA damage, regulating between cell cycle arrest when DDB2 is present versus when DDB2 is absent, as shown in WT and DDB2−/− MEFs.
“DDB2 was found to regulate between cell cycle arrest with DDB2 present versus cell cycle arrest when DDB2 is absent through experiments performed in WT and DDB2−/− MEFs [50,51].”
From Integration of DNA damage and repair with murine double-minute 2 (Mdm2) in tumorigenesis (2012) · cites this paper as [51]
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References 52 · Cited by 70
- Authors
- Stoyanova, T., Roy, N., Kopanja, D., Raychaudhuri, P., & Bagchi, S.
- Affiliations
- University of Illinois Chicago (US)
- Corresponding author
- Bagchi, Srilata
- Venue
- Cell Cycle
- Publisher
- Informa UK Limited
- Published
- 2009-12-15
- Volume
- 8
- Issue
- 24
- Pages
- 4067-4071
- ISSN
- 1538-4101 (ISSN-L)
- 1551-4005
- PMC
- PMC3107032
- OpenAlex
- W1968431299
- Cited by
- 70
- References
- 52
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 8 · 2023: 4 · 2022: 11 · 2021: 5 · 2020: 4 · 2019: 5 · 2018: 3 · 2017: 1 · 2016: 1 · 2015: 5 · 2013: 5 · 2012: 3
- FWCI
- 0.28
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cell Cycle (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (R01AG024138, AG024138)
- National Cancer Institute (R01CA077637)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Keywords
- DDB2, nucleotide excision repair, DNA damage response, UV-induced DNA damage, E3 ubiquitin ligase, programmed cell death, DNA repair, carcinogenesis
- MeSH terms
- Animals, DNA, DNA Damage, DNA Repair, DNA-Binding Proteins, Humans, Apoptosis, Ubiquitin-Protein Ligases, Proteasome Endopeptidase Complex, Cyclin-Dependent Kinase Inhibitor p21
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