Epidermal surface lipids
Open accessAbstract
A layer of lipids, which are of both sebaceous and keratinocyte origin, covers the surface of the skin. The apparent composition of surface lipids varies depending on the selected method of sampling. Lipids produced by the epidermal cells are an insignificant fraction of the total extractable surface lipid on areas rich in sebaceous glands. Due to the holocrine activity of the sebaceous gland, its product of secretion (sebum) is eventually released to the surface of the skin and coats the fur as well. Lipids of epidermal origin fill the spaces between the cells, like mortar or cement. The sebaceous lipids are primarily non polar lipids as triglycerides, wax esters and squalene, while epidermal lipids are a mixture of ceramides, free fatty acids and cholesterol. The composition of the sebaceous lipids is unique and intriguing and elevated sebum excretion is a major factor involved in the pathophysiology of acne. Recent studies have elucidated the roles that epidermal surface lipids have on normal skin functions and acne.
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Sebaceous lipids consist of free fatty acids, squalene, and triglycerides, which contribute to moisturization and antibacterial activity.
“Lipids consist of free fatty acids, squalene, and triglycerides, which contribute to moisturization and antibacterial activity42.”
From Morphological characteristics and notes of the skin in preclinical toxicity assessment (2023) · cites this paper as [42]
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References 60 · Cited by 326
- Authors
- Pappas, A.
- Affiliations
- Johnson & Johnson (United States) (US)
- Corresponding author
- Pappas, Apostolos
- ORCID
- Pappas, Apostolos
- Venue
- Dermato-Endocrinology
- Publisher
- Informa UK Limited
- Published
- 2009-03
- Volume
- 1
- Issue
- 2
- Pages
- 72-76
- ISSN
- 1938-1972 (ISSN-L)
- 1938-1980
- PMC
- PMC2835894
- OpenAlex
- W2128085440
- Cited by
- 326
- References
- 60
- Citations by year
- 2026: 16 · 2025: 27 · 2024: 32 · 2023: 30 · 2022: 29 · 2021: 33 · 2020: 36 · 2019: 21 · 2018: 20 · 2017: 25 · 2016: 14 · 2015: 14 · 2014: 8 · 2013: 9 · 2012: 4
- FWCI
- 5.02
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Dermato-Endocrinology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advancements in Transdermal Drug Delivery
- Health Sciences › Medicine › Dermatology › Acne and Rosacea Treatments and Effects
- Keywords
- sebum, sebaceous glands, ceramide, free fatty acids, cholesterol, squalene, wax esters, triglycerides, acne pathophysiology, skin barrier function
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