The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Smyd3 regulates cancer cell phenotypes and catalyzes histone H4 lysine 5 methylation
Open accessAbstract
Smyd3 is a lysine methyltransferase implicated in chromatin and cancer regulation. Here we show that Smyd3 catalyzes histone H4 methylation at lysine 5 (H4K5me). This novel histone methylation mark is detected in diverse cell types and its formation is attenuated by depletion of Smyd3 protein. Further, Smyd3-driven cancer cell phenotypes require its enzymatic activity. Thus, Smyd3, via H4K5 methylation, provides a potential new link between chromatin dynamics and neoplastic disease.
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Citations
Cites
Chromatin modifications and their function
Kouzarides, T. (2007) · Cell · doi:10.1016/j.cell.2007.02.005 · Cited by 10,883
Cited by
Quantitative Proteomic Analysis of Histone Modifications
Huang, H., Lin, S., Garcia, B. A., & Zhao, Y. (2015) · Chemical Reviews · doi:10.1021/cr500491u · Cited by 370
Self-citationSET for life: biochemical activities and biological functions of SET domain-containing proteins
Herz, H.-M., Garruss, A., & Shilatifard, A. (2013) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2013.09.004 · Cited by 314
Mitchell, L. H., Boriack-Sjodin, P. A., Smith, S., Thomenius, M., Rioux, N., Munchhof, M., Mills, J. E., Klaus, C., Totman, J., Riera, T. V., et al. (2016) · ACS Medicinal Chemistry Letters · doi:10.1021/acsmedchemlett.5b00272 · Cited by 91
Fu, W., Liu, N., Qiao, Q., Wang, M., Min, J., Zhu, B., Xu, R.-M., & Yang, N. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.709832 · Cited by 38
Metadata
- Authors
- Van Aller, G. S., Reynoird, N., Barbash, O., Huddleston, M., Liu, S., Zmoos, A.-F., McDevitt, P., Sinnamon, R., Le, B., Mas, G., Annan, R., Sage, J., Garcia, B. A., Tummino, P. J., Gozani, O., & Kruger, R. G.
- Venue
- Epigenetics
- Publisher
- Informa UK Limited
- Published
- 2012-04
- Volume
- 7
- Issue
- 4
- Pages
- 340-343
- ISSN
- 1559-2294 (ISSN-L)
- 1559-2308
- OpenAlex
- W2051406272
- Cited by
- 170
- References
- 1
- FWCI
- 5.11
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- The paper
- Van Aller, G. S., Reynoird, N., Barbash, O., Huddleston, M., Liu, S., Zmoos, A.-F., McDevitt, P., Sinnamon, R., Le, B., Mas, G., Annan, R., Sage, J., Garcia, B. A., Tummino, P. J., Gozani, O., & Kruger, R. G. (2012). Smyd3 regulates cancer cell phenotypes and catalyzes histone H4 lysine 5 methylation. Epigenetics. https://doi.org/10.4161/epi.19506
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
