A novel SCFA receptor, the microbiota, and blood pressure regulation
Open accessAbstract
The maintenance of blood pressure homeostasis is a complex process which is carefully regulated by a variety of inputs. We recently identified two sensory receptors (Olfactory receptor 78 and G protein couple receptor 41) as novel regulators of blood pressure. Both Olfr78 and Gpr41 are receptors for short chain fatty acids (SCFAs), and we showed that propionate (a SCFA) modifies blood pressure in a manner which is differentially modulated by the absence of either Olfr78 or Gpr41. In addition, propionate modifies renin release in an Olfr78-dependent manner. Our study also demonstrated that antibiotic treatment modulates blood pressure in Olfr78 null mice, indicating that SCFAs produced by the gut microbiota likely influence blood pressure regulation. In this addendum, we summarize the findings of our recent study and provide a perspective on the implications of the interactions between the gut microbiota and blood pressure control.
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Olfr78 and Gpr41 participate in host blood pressure regulation.
“Early mechanistic studies by Pluznick and colleagues substantiated this idea by demonstrating the G-protein coupled SCFA receptors olfactory receptor 78 (Olfr78) and G-protein receptor 41 (Gpr41) participate in host blood pressure regulation59–61.”
From Gut microbiota and cardiovascular disease. (2020) · cites this paper as [59]
A significant proportion of SCFAs produced in the distal bowel is reabsorbed from the gut lumen by facilitated apical solute transport via multiple transporters and passive diffusion.
“A significant proportion of the SCFAs produced in the distal bowel is reabsorbed from the gut lumen by facilitated apical solute transport via multiple different transporters114–117 as well as via passive (concentration-dependent) diffusion118.”
From Dietary metabolism, the gut microbiome, and heart failure (2019) · cites this paper as [117]
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References 68 · Cited by 374
Research works printed but not linked: 1
- Pluznick JL, Protzko RJ, Gevorgyan H, Peterlin Z, Sipos A, Han J, Brunet I, Wan LX, Rey F, Wang T, et al. Olfactory receptor responding to gut microbi- ota-derived signals plays a role in renin secretion and blood pressure regulation. Proc Natl Acad Sci U S A 2013; 110:4410-5; PMID:23401498; http://dx.doi. org/10.1073/pnas.1215927110 · DOI · Paper page
- Authors
- Pluznick, J.
- Affiliations
- Johns Hopkins University (US)
- Corresponding author
- Pluznick, Jennifer
- ORCID
- Pluznick, Jennifer
- Venue
- Gut Microbes
- Publisher
- Informa UK Limited
- Published
- 2013-12-20
- Volume
- 5
- Issue
- 2
- Pages
- 202-207
- ISSN
- 1949-0976 (ISSN-L)
- 1949-0984
- PMC
- PMC4063845
- OpenAlex
- W2091512742
- Cited by
- 374
- References
- 68
- Citations by year
- 2026: 17 · 2025: 30 · 2024: 37 · 2023: 34 · 2022: 48 · 2021: 45 · 2020: 41 · 2019: 39 · 2018: 33 · 2017: 25 · 2016: 15 · 2015: 10
- FWCI
- 3.73
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Gut Microbes (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- American Society of Nephrology
- National Institutes of Health
- U.S. Public Health Service (R0ODK081610)
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK089502, R00DK081610)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
- Keywords
- short-chain fatty acids, blood pressure regulation, GPR41, gut microbiota, propionate, renin secretion, olfactory receptors, G protein-coupled receptors, antibiotic therapy, gut-brain axis
- MeSH terms
- Animals, Anti-Bacterial Agents, Blood Pressure, Fatty Acids, Volatile, Mice, Knockout, Gastrointestinal Tract, Receptors, G-Protein-Coupled, Mice, Microbiota
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