Obesity-induced chronic inflammation is associated with the reduced efficacy of influenza vaccine
Open accessAbstract
The relationship between obesity and vaccine efficacy is a serious issue. Previous studies have shown that vaccine efficacy is lower in the obese than in the non-obese. Here, we examined the influence of obesity on the efficacy of influenza vaccination using high fat diet (HFD) and regular fat diet (RFD) mice that were immunized with 2 types of influenza virus vaccines-cell culture-based vaccines and egg-based vaccines. HFD mice showed lower levels of neutralizing antibody titers as compared with RFD mice. Moreover, HFD mice showed high levels of MCP-1 in serum and adipocytes, and low level of influenza virus-specific effector memory CD8(+) T cells. After challenge with influenza virus, the lungs of HFD mice showed more severe inflammatory responses as compared with the lungs of RFD mice, even after vaccination. Taken together, our data suggested that the inflammatory condition in obesity may contribute to the suppressed efficacy of influenza vaccination.
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In mice, the inflammatory condition associated with obesity limits the antibody response to, and efficacy of, influenza vaccination.
“It has been shown in mice that the inflammatory condition associated with obesity limits the antibody response to, and efficacy of, influenza vaccination [156].”
From Aging of the immune system: Focus on inflammation and vaccination (2016) · cites this paper as [156]
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References 24 · Cited by 113
Research works printed but not linked: 2
- Davies RJ, Wells ID. Influenza virus vaccine and egg allergy. Proc R Soc Med 1975; 68:218; PMID:1239018
- Wright PF, Webster RG. Orthomyxoviruses. In: Field virology. 4th edition. Philadelphia: Lippincott Williams & Wilkins 2001; 1533-79.
- Authors
- Park, H.-L., Shim, S.-H., Lee, E.-Y., Cho, W., Park, S., Jeon, H.-J., Ahn, S.-Y., Kim, H., & Nam, J.-H.
- Affiliations
- Catholic University of Korea (KR)
- Corresponding author
- Nam, Jae-Hwan
- Venue
- Human Vaccines & Immunotherapeutics
- Publisher
- Informa UK Limited
- Published
- 2014-03-10
- Volume
- 10
- Issue
- 5
- Pages
- 1181-1186
- ISSN
- 2164-5515 (ISSN-L)
- 2164-554X
- PMC
- PMC4896564
- OpenAlex
- W2082408777
- Cited by
- 113
- References
- 24
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 11 · 2023: 11 · 2022: 20 · 2021: 17 · 2020: 11 · 2019: 9 · 2018: 5 · 2017: 8 · 2016: 6 · 2015: 4 · 2014: 1
- FWCI
- 4.79
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Human Vaccines & Immunotherapeutics (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Gyeonggi-do Regional Research Center
- Topics
- Health Sciences › Medicine › Epidemiology › Influenza Virus Research Studies
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Keywords
- obesity, influenza vaccine efficacy, chronic inflammation, high-fat diet, neutralizing antibodies, MCP-1, adipocytes, CD8+ T cells, lung inflammation, egg-based vaccine, influenza
- MeSH terms
- Animals, Inflammation, Influenza Vaccines, Lung, Male, Mice, Inbred C57BL, Obesity, Treatment Outcome, CD8-Positive T-Lymphocytes, Chemokine CCL2, Mice, Diet, High-Fat
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