A strategy for risk mitigation of antibodies with fast clearance

Hötzel, Isidro, Theil, Frank-Peter, Bernstein, Lisa J., Prabhu, Saileta, Deng, Rong, Quintana, Leah, Lutman, Jeff, Sibia, Renuka +5 more·2012·mAbs
DOI 10.4161/mabs.22189

Cited by (245)

Items 201–245 of 245

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  16. Coupling cation and anion exchange chromatography for fast separation of monoclonal antibody charge variants
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  17. High titer expression of antibodies using linear expression cassettes for early-stage functional screening
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  18. Biodistribution of Therapeutic Biologics: Methods and Applications in Informing Target Biology, Pharmacokinetics, and Dosing Strategies
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  19. Target‐Driven Pharmacokinetics of Biotherapeutics
    Guy M. L. Meno‐Tetang · 2015 · Pharmaceutical Sciences Encyclopedia
  20. Ultra-high-diversity factorizable libraries for efficient therapeutic discovery
    Zheng Dai, Sachit D. Saksena, Geraldine Horny, Christine Banholzer, Stefan Ewert, David Kenneth Gifford · 2022 · Genome Research
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  22. Analytical Characterization of Bispecific Antibodies and Bispecific Molecules
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  23. Influence of the antibody variable domain on FcRn-dependent pharmacokinetics
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  24. Therapeutic Antibodies—Protein Engineering to Influence ADME , PK , and Efficacy
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  25. Characterization of Bispecific or Other Hybrid Molecules
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  26. Molecular Imaging Agent Design for Quantifying Beta Cell Mass in Type 1 Diabetes
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  27. Interaction of clinical-stage antibodies with heme predicts their physiochemical and binding qualities
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  28. Directed Evolution of Antibodies Against Complex Targets
    Alec A. Desai · 2021 · Deep Blue (University of Michigan)
  29. Biotherapeutics ADME and PK/PD Principles
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  30. Ultra high diversity factorizable libraries for efficient therapeutic discovery
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  31. Preferential precipitation for reducing acidic variant content in monoclonal antibody pools
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  32. Preferential Precipitation for Reducing Acidic Variant Contentin Monoclonal Antibody Pools
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  45. Monoclonal antibody developability from early assay panels: machine learning for formulation and pharmacokinetic risk
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