Distribution, function and predictive value of tumor-infiltrating γδ T lymphocytes
Open accessAbstract
Although γδ T cells are known to exert both tumor-preventing and tumor-promoting activity, there is still little information on the functional characteristics and clinical significance of γδ T cells isolated from the tumor site. In a recent study, we have investigated the distribution of different γδ T-cell populations in melanoma and their impact on disease outcome.
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During lung infection, Vγ9Vδ2 γδ T cells are aggregated to produce IL-17 and IFN-γ, the former being the most important cytokine in TB protection.
“During lung infection, Vγ9Vδ2 γδ T cells are aggregated to produce IL-17 and IFN-γ, the former being the most important cytokine in TB protection (43).”
From Comparing Mouse and Human Tissue-Resident γδ T Cells (2022) · cites this paper as [43]
The Abstract (page unavailable) reports that melanoma-derived Vδ2 T-cell lines produced IFNγ. It does not address Vγ9Vδ2 cells accumulating during lung infection, their production of IL-17, or IL-17’s importance in TB protection. (LLM, conf=0.78)
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Research works printed but not linked: 8
- [1]Gooden MJ de Bock GH Leffers N Daemen T Nijman HW The prognostic influence of tumour-infiltrating lymphocytes in cancer: a systematic review with meta-analysis Br J Cancer 2011 105 93 103 10.1038/bjc.2011.189 21629244 PMC3137407 · DOI
- [2]Hayday AC Gammadelta T cells and the lymphoid stress-surveillance response Immunity 2009 31 184 96 10.1016/j.immuni.2009.08.006 19699170 · DOI
- [3]Hannani D Ma Y Yamazaki T Déchanet-Merville J Kroemer G Zitvogel L Harnessing γδ T cells in anticancer immunotherapy Trends Immunol 2012 33 199 206 10.1016/j.it.2012.01.006 22364810 · DOI
- [4]Caccamo N Todaro M Sireci G Meraviglia S Stassi G Dieli F Mechanisms underlying lineage commitment and plasticity of human γδ T cells Cell Mol Immunol 2013 10 30 4 23085943 PMC4003171
- [5]Cordova A Toia F La Mendola C Orlando V Meraviglia S Rinaldi G Characterization of human γδ T lymphocytes infiltrating primary malignant melanomas PLoS One 2012 7 e49878 10.1371/journal.pone.0049878 23189169 PMC3506540 · DOI
- [6]Dieli F Poccia F Lipp M Sireci G Caccamo N Di Sano C Differentiation of effector/memory Vdelta2 T cells and migratory routes in lymph nodes or inflammatory sites J Exp Med 2003 198 391 7 10.1084/jem.20030235 12900516 PMC2194087 · DOI
- [7]Inman BA Frigola X Harris KJ Kuntz SM Lohse CM Leibovich BC Questionable relevance of γ δ T lymphocytes in renal cell carcinoma J Immunol 2008 180 3578 84 18292585 PMC2792739
- [8]Ma C Zhang Q Ye J Wang F Zhang Y Wevers E Tumor-infiltrating γδ T lymphocytes predict clinical outcome in human breast cancer J Immunol 2012 189 5029 36 10.4049/jimmunol.1201892 23034170 PMC4832413 · DOI
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Comparing Mouse and Human Tissue-Resident γδ T Cells
Qu, G., Wang, S., Zhou, Z., Jiang, D., Liao, A., & Luo, J. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.891687 · Cited by 87 · see citing works
- Authors
- Dieli, F., Stassi, G., Todaro, M., Meraviglia, S., Caccamo, N., & Cordova, A.
- Affiliations
- University of Palermo (IT)
- Corresponding author
- Dieli, Francesco
- Venue
- OncoImmunology
- Publisher
- Informa UK Limited
- Published
- 2013-04
- Volume
- 2
- Issue
- 4
- Pages
- e23434
- ISSN
- 2162-4011 (ISSN-L)
- 2162-402X
- PMC
- PMC3654575
- OpenAlex
- W1996320851
- Cited by
- 7
- References
- 0
- Citations by year
- 2022: 2 · 2020: 1 · 2019: 1 · 2017: 1 · 2016: 1 · 2013: 1
- FWCI
- 0.36
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc
- Locations
- OncoImmunology (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Nova Science Publishers (Nova Science Publishers, Inc.) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Keywords
- γδ T cells, tumor-infiltrating lymphocytes, melanoma, tumor immunology, prognostic value, tumor microenvironment, disease outcome
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