Immunological effects of the TGFβ-blocking antibody GC1008 in malignant pleural mesothelioma patients

Stevenson, James P; Kindler, Hedy L; Papasavvas, Emmanouil; Sun, Jing; Jacobs-Small, Mona; Hull, Jennifer; Schwed, Daniel; Ranganathan, Anjana; Newick, Kheng; Heitjan, Daniel F; Langer, Corey J; McPherson, John M; Montaner, Luis J; Albelda, Steven M

doi:10.4161/onci.26218

Immunological effects of the TGFβ-blocking antibody GC1008 in malignant pleural mesothelioma patients

We evaluated a neutralizing anti-TGFβ antibody (GC1008) in cancer patients with malignant pleura mesothelioma (MPM). The goal of this study was to assess immunoregulatory effects in relation to clinical safety and clinical response. Patients with progressive MPM and 1–2 prior systemic therapies r…