Analysis of the Arabidopsis dry2/sqe1-5 mutant suggests a role for sterols in signaling
Open accessAbstract
Sterols play multi-faceted roles in all eukaryotes. In plants, there are mounting evidences pointing to sterols, other than BRs, can act as signaling molecules. The Arabidopsis dry2/sqe1-5 mutant has multiple developmental defects caused by a point mutation in the SQE1 gene that generates a hypomorphic allele. SQE1 encodes a squalene epoxidase, which converts squalene into 2,3-oxidosqualene the precursor of plant sterols. Genetic, molecular and biochemical analyses suggest that dry2/sqe1-5 defective phenotypes cannot be simply explained by a depletion of bulk sterols but rather by altered ROS. It remains to be elucidated whether the altered ROS production of the mutant is caused by membrane composition, which in turn affect the lipid rafts composition and/or an altered signaling.
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Only one other null eukaryotic mutation of Sqle has been identified, resulting in an inability for plants to tolerate drought stress.
“Only one other null eukaryotic mutation of Sqle has been identified, resulting in an inability for plants to tolerate drought stress26,27.”
From A suppressor screen in Mecp2 mutant mice implicates cholesterol metabolism in Rett syndrome (2013) · cites this paper as [26]
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A suppressor screen in Mecp2 mutant mice implicates cholesterol metabolism in Rett syndrome
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Light Intensity- and Spectrum-Dependent Redox Regulation of Plant Metabolism
Borbély, P., Gasperl, A., Pálmai, T., Ahres, M., Asghar, M. A., Galiba, G., Müller, M., & Kocsy, G. (2022) · Antioxidants · doi:10.3390/antiox11071311 · Cited by 85 · see citing works
Almagro, L., García-Pérez, P., Navarro, S. B., Sánchez-Pujante, P. J., & Pedreño, M. A. (2015) · Plant Physiology and Biochemistry · doi:10.1016/j.plaphy.2015.12.009 · Cited by 22 · see citing works
Almagro, L., Tudela, L. R., Sabater‐Jara, A. B., Miras‐Moreno, B., & Pedreño, M. A. (2017) · Biotechnology Progress · doi:10.1002/btpr.2525 · Cited by 9 · see citing works
“Phytosterols are components of the cellular membranes and they can modulate their fluidity and permeability.(5) The phytosterols reduce the cholesterol levels,(6) they also have antioxidant, anti-inflammatory and antitumoral activities.”
BackgroundZhang, C., Li, G.-Z., Gong, R., Zhang, Y.-F., Lu, P., Dai, C., Fan, N.-N., Yao, W.-Y., Shi, X., Dong, J.-G., et al. (2026) · Theoretical and Applied Genetics · doi:10.1007/s00122-026-05230-9 · Cited by 1
van Bezouw, R. F. H. M., Nguyen, T., Hoang, N. V., Vincenzi, E., van Velthoven, R., Zhang, H., Gao, Y., Zhang, W., Jacobi, R., de Snoo, B., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.09.21.558849
- Authors
- Posé, D., & Botella, M. A.
- Affiliations
- Universidad de Málaga (ES)
- Venue
- Plant Signaling & Behavior
- Publisher
- Informa UK Limited
- Published
- 2009-09
- Volume
- 4
- Issue
- 9
- Pages
- 873-874
- ISSN
- 1559-2316 (ISSN-L)
- 1559-2324
- PMC
- PMC2802798
- OpenAlex
- W1994114946
- Cited by
- 7
- References
- 0
- Citations by year
- 2026: 1 · 2023: 1 · 2022: 1 · 2017: 1 · 2015: 1 · 2013: 1 · 2012: 1
- FWCI
- 0.13
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Plant Signaling & Behavior (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Plant biochemistry and biosynthesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Stress Responses and Tolerance
- Keywords
- squalene epoxidase, Arabidopsis thaliana, reactive oxygen species, 2,3-oxidosqualene, phytosterols, membrane composition, lipid rafts, hypomorphic allele
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