Barriers to drug delivery in solid tumors

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Items 101–200 of 340

1. Single-Stranded DNA-Packaged Polyplex Micelle as Adeno-Associated-Virus-Inspired Compact Vector to Systemically Target Stroma-Rich Pancreatic Cancer
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2. Immunomodulatory nanoparticles activate cytotoxic T cells for enhancement of the effect of cancer immunotherapy
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3. Targeted polymer-drug conjugates: Current progress and future perspective
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4. The assembly and antitumor activity of lycium barbarum polysaccharide-platinum-based conjugates
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5. Cytotoxicity of Novel Redox Sensitive PEG2000-S-S-PTX Micelles against Drug-Resistant Ovarian and Breast Cancer Cells
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6. Drug Release via Ultrasound-Activated Nanocarriers for Cancer Treatment: A Review
   Khaled Armouch Al Refaai, Nour A. AlSawaftah, Waad H. Abuwatfa, Ghaleb A. Husseini · 2024 · Pharmaceutics
7. Exploring the role of polymeric conjugates toward anti-cancer drug delivery: Current trends and future projections
   Junaid Ali Khan, Amit Alexander, M. Ajazuddin, Swarnlata Saraf, Shailendra Saraf · 2018 · International Journal of Pharmaceutics
8. In vivo fate of folate–BSA in non‐tumor‐ and tumor‐bearing mice
   Tatsuki Shinoda, Akira Takagi, Atsushi Maeda, Seiya Kagatani, Yutaka Konno, Mitsuru Hashida · 1998 · Journal of Pharmaceutical Sciences
9. In situ forming oxygen/ROS-responsive niche-like hydrogel enabling gelation-triggered chemotherapy and inhibition of metastasis
   Shixiong Chen, Ji Zhang, Fengfeng Xue, Wei Liu, Yichen Kuang, Bingxin Gu, Shaoli Song, Hangrong Chen · 2022 · Bioactive Materials
10. Development of Thiol-Maleimide hydrogels incorporating graphene-based nanomaterials for cancer chemo-photothermal therapy
    Francisco J.P. Costa, Micaela Nave, Rita Lima‐Sousa, Cátia G. Alves, Bruna L. Melo, Ilídio Joaquim Correia, Duarte de Melo‐Diogo · 2023 · International Journal of Pharmaceutics
11. A Robust Design for Cellular Vehicles of Gold Nanorods for Multimodal Imaging
    Fulvio Ratto, Sonia Centi, Cinzia Avigo, Claudia Borri, Francesca Tatini, Lucia Cavigli, Claudia Kusmic, Beatrice Lelli, Sarah Lai, Stefano Colagrande et al. · 2016 · Advanced Functional Materials
12. Liposomal Nanostructures for Drug Delivery in Gastrointestinal Cancers
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13. Organ-based drug delivery
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14. Deeply Infiltrating iRGD‐Graphene Oxide for the Intensive Treatment of Metastatic Tumors through PTT‐Mediated Chemosensitization and Strengthened Integrin Targeting‐Based Antimigration
    Honglan Wang, Jiyuan Zhou, Ying Fu, Yuzhao Zheng, Weiyang Shen, Jianping Zhou, Tingjie Yin · 2021 · Advanced Healthcare Materials
15. Amateur antigen‐presenting cells in the tumor microenvironment
    Laurel B. Darragh, Sana D. Karam · 2021 · Molecular Carcinogenesis
16. Computational Modeling of Combination of Magnetic Hyperthermia and Temperature-Sensitive Liposome for Controlled Drug Release in Solid Tumor
    Masoud H.H. Tehrani, Madjid Soltani, Farshad Moradi Kashkooli, Mohammadreza Mahmoudi, Kaamran Raahemifar · 2021 · Pharmaceutics
17. Dually responsive mesoporous silica nanoparticles regulated by upper critical solution temperature polymers for intracellular drug delivery
    Mingyang Hei, Jun Wang, Kelly Wang, Weiping P. Zhu, Peter X. Ma · 2017 · Journal of Materials Chemistry B
18. Polydopamine surface-modified nanocarriers for improved anticancer activity: Current progress and future prospects
    Sandip Mohan Honmane, Manoj Shrawan Charde, Sachin S. Salunkhe, Prafulla Balkrishna Choudhari, Sopan Nangare · 2022 · OpenNano
19. Prior anti-CAFs break down the CAFs barrier and improve accumulation of docetaxel micelles in tumor
    Ning Pang, Ji Li, Aning Sun, Zhenzhen Yang, Shixuan Cheng, Xian Qi · 2018 · International Journal of Nanomedicine
20. Morphophenotypic classification of tumor organoids as an indicator of drug exposure and penetration potential
    Aleksandra M. Karolak, Sharan Poonja, Katarzyna Anna Rejniak · 2019 · PLoS Computational Biology
21. Ultrasound-mediated microbubbles cavitation enhanced chemotherapy of advanced prostate cancer by increasing the permeability of blood-prostate barrier
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22. Multifunctional nanodiamonds as emerging platforms for cancer treatment, and targeted delivery of genetic factors and protein medications—a review
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23. Superparamagnetic reconstituted high-density lipoprotein nanocarriers for magnetically guided drug delivery
    Sarika Sabnis, Nirupama A. Sabnis, Sangram Raut, Andras G. Lacko · 2017 · International Journal of Nanomedicine
24. Tailoring radiotherapies and nanotechnology for targeted treatment of solid tumors
    Muhammad Imran Khan, Fakhra Batool, Rizwan Ali, Qurat ul ain Zahra, Wenshen Wang, Shibo Li, Gangguo Wang, Liangliang Liu, Safir Ullah Khan, Majad Mansoor et al. · 2022 · Coordination Chemistry Reviews
25. HIF2α-Targeted RNAi Therapeutic Inhibits Clear Cell Renal Cell Carcinoma
    So C. Wong, Weijun Cheng, Holly Hamilton, Anthony L. Nicholas, Darren H. Wakefield, Aaron Almeida, Andrei V. Blokhin, Jeffrey C. Carlson, Zane C. Neal, Vladimir M. Subbotin et al. · 2017 · Molecular Cancer Therapeutics
26. Impact of the hypoxic phenotype on the uptake and efflux of nanoparticles by human breast cancer cells
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27. Selective Targeting of Cancer Signaling Pathways with Nanomedicines: Challenges and Progress
    Harshita Abul Barkat, Sabya Sachi Das, Md. Abul Barkat, Sarwar Beg, Hazrina Ab. Hadi · 2020 · Future Oncology
28. Targeted Nanotherapeutics for Respiratory Diseases: Cancer, Fibrosis, and Coronavirus
    Joydeb Majumder, Tamara Minko · 2020 · Advanced Therapeutics
29. Blood Vessels and Peripheral Nerves as Key Players in Cancer Progression and Therapy Resistance
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30. Cytotoxicity of PEGylated liposomes co-loaded with novel pro-apoptotic drug NCL-240 and the MEK inhibitor cobimetinib against colon carcinoma in vitro
    Shravan Kumar Sriraman, Vananélia P.N. Geraldo, Ed Luther, Alexei Degterev, Vladimir P. Torchilin · 2015 · Journal of Controlled Release
31. Oncolytic bacteria: past, present and future
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32. Microfluidic one-directional interstitial flow generation from cancer to cancer associated fibroblast
    Jaehoon Kim, Hyejin Park, Hyunho Kim, YongTae Kim, Hyun Jeong Oh, Seok Hwan Chung · 2022 · Acta Biomaterialia
33. Lipid-Based Nano-Sized Cargos as a Promising Strategy in Bone Complications: A Review
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34. Cancer Nano-Immunotherapy: The Novel and Promising Weapon to Fight Cancer
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35. Hybrid micelles codelivering shikonin and IDO-1 siRNA enhance immunotherapy by remodeling immunosuppressive tumor microenvironment
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36. Regulating Oncogenic LncRNA DANCR with Targeted ECO/siRNA Nanoparticles for Non-Small Cell Lung Cancer Therapy
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37. Nano-drug delivery system for pancreatic cancer: A visualization and bibliometric analysis
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38. Exploring Advanced CRISPR Delivery Technologies for Therapeutic Genome Editing
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39. Anticancer lipid-based drug delivery systems: Basic knowledge and recent applications
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40. A multifunctional organosilica cross-linker for the bio-conjugation of gold nanorods
    Sarah Lai, Sonia Centi, Claudia Borri, Fulvio Ratto, Lucia Cavigli, Filippo Micheletti, Björn Kemper, Steffi Ketelhut, Tatiana Kozyreva, Leonardo Gonnelli et al. · 2017 · Colloids and Surfaces B Biointerfaces
41. Photostability of Gold Nanorods upon Endosomal Confinement in Cultured Cells
    Lucia Cavigli, Alberto Cini, Sonia Centi, Claudia Borri, Sarah Lai, Fulvio Ratto, Marella de Angelis, Roberto Pini · 2017 · The Journal of Physical Chemistry C
42. Sonopermeation with Nanoparticle‐Stabilized Microbubbles Reduces Solid Stress and Improves Nanomedicine Delivery to Tumors
    Einar Sulheim, Ingunn Hanson, Sofie Snipstad, Krister Vikedal, Yrr A. Mørch, Yves Boucher, Catharina de Lange Davies · 2021 · Advanced Therapeutics
43. Dual pH-Responsive and Tumor-Targeted Nanoparticle-Mediated Anti-Angiogenesis siRNA Delivery for Tumor Treatment
    Xiangyang Zhang, Bin Qin, Min Wang, Junyi Feng, Chenglin Zhang, Chengshen Zhu, Suqin He, Hao Liu, Yaohe Wang, Saadyah E. Averick et al. · 2022 · International Journal of Nanomedicine
44. Versatile and Robust Method for Antibody Conjugation to Nanoparticles with High Targeting Efficiency
    Indra Van Zundert, Maria Bravo, Olivier Deschaume, Pierre Cybulski, Carmen Bartic, Johan Hofkens, Hiroshi Uji‐i, Beatrice Fortuni, Susana Rocha · 2021 · Pharmaceutics
45. Trends in Nanotechnology to improve therapeutic efficacy across special structures
    Muhammad Imran Khan, Qurat ul ain Zahra, Fakhra Batool, Fadi Kalsoom, Shuang Gao, Rizwan Ali, Wenshen Wang, Ahsan Kazmi, Liu Lianliang, Gangguo Wang et al. · 2022 · OpenNano
46. The role of acoustofluidics and microbubble dynamics for therapeutic applications and drug delivery
    S. Ilke Kaykanat, A. Kerem Uğuz · 2023 · Biomicrofluidics
47. Combinatorial approaches of nanotherapeutics for inflammatory pathway targeted therapy of prostate cancer
    Renjith P. Johnson, Chandrahas Koumar Ratnacaram, Lalit Kumar, Jobin Jose · 2022 · Drug Resistance Updates
48. Improving the Efficacy of Anticancer Drugs via Encapsulation and Acoustic Release
    Salma Elgaili Ahmed, Nahid S. Awad, Vinod Paul, Hesham G. Moussa, Ghaleb A. Husseini · 2018 · Current Topics in Medicinal Chemistry
49. In Vitro Low-Fluence Photodynamic Therapy Parameter Screening Using 3D Tumor Spheroids Shows that Fractionated Light Treatments Enhance Phototoxicity
    Jose R. Aguilar Cosme, Dan C. Gagui, Nicola Helen Green, Helen E. Bryant, Frederik Claeyssens · 2021 · ACS Biomaterials Science & Engineering
50. Micro and Nanotechnologies for Biotechnology
    Stefan G. Stanciu · 2016 · InTech eBooks
51. Seeing Better and Going Deeper in Cancer Nanotheranostics
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52. A high tumour-stroma ratio (TSR) in colon tumours and its metastatic lymph nodes predicts poor cancer-free survival and chemo resistance
    Strous, M. T. A., Faes, T. K. E., Gubbels, A. L. H. M., van der Linden, R. L. A., Mesker, W. E., Bosscha, K., Bronkhorst, C. M., Janssen-Heijnen, M. L. G., Vogelaar, F. J., de Bruïne, A. P. · 2022 · Clinical and Translational Oncology
53. Enhancing Targeted Therapy in Breast Cancer by Ultrasound-Responsive Nanocarriers
    Isaiah A. Edwards, Flavia De Carlo, Juliana Sitta, William Varner, Candace M. Howard, Pier Paolo Claudio · 2023 · International Journal of Molecular Sciences
54. On-Chip Preparation of Amphiphilic Nanomicelles–in–Sodium Alginate Spheroids as a Novel Platform Against Triple-Negative Human Breast Cancer Cells: Fabrication, Study of Microfluidics Flow Hydrodynamics and Proof of Concept for Anticancer and Drug Delivery Applications
    Doaa Ragab, Sally A. Sabra, Ying Xia, David B. Goodale, Alison L. Allan, Sohrab Rohani · 2019 · Journal of Pharmaceutical Sciences
55. Cancer nanomedicine: emergence, expansion, and expectations
    Keerthana Suresh Kizhakkanoodan, Yuvraj Rallapalli, Joyceline Praveena, Sriprasad Acharya, Bharath Raja Guru · 2023 · SN Applied Sciences
56. Core-Shell Microspheres Prepared Using Coaxial Electrostatic Spray for Local Chemotherapy of Solid Tumors
    Xiaowei Zhang, Rundong Zhu, Xingzhi Wang, Hao Wang, Zushun Xu, Yongan Wang, Dongqin Quan, Liao Shen · 2023 · Pharmaceutics
57. Pulmonary delivery of dual-targeted nanoparticles improves tumor accumulation and cancer cell targeting by restricting macrophage interception in orthotopic lung tumors
    Di Ge, Siqi Ma, Tingting Sun, Yunfei Li, Jiaxing Wei, Chenao Wang, Xiaoyuan Shawn Chen, Yonghong Liao · 2024 · Biomaterials
58. Delivery of Chemotherapy Agents and Nucleic Acids with pH-Dependent Nanoparticles
    Qixin Leng, Zuha Imtiyaz, Martin C. Woodle, Archibald James Mixson · 2023 · Pharmaceutics
59. Capillary collagen as the physical transport barrier in drug delivery to tumor microenvironment
    Artūras Žiemys, Kenji Yokoi, Miloš Kojić · 2015 · Tissue Barriers
60. Supramolecular agents for theranostics
    Sergey Mikhailovich Deyev, Ekaterina N. Lebedenko · 2015 · Russian Journal of Bioorganic Chemistry
61. Drug penetration in pediatric brain tumors: Challenges and opportunities
    Jenny P. Patel, Susan E. Spiller, Elizabeth D. Barker · 2021 · Pediatric Blood & Cancer
62. Targeted Bifunctional Proteins and Hybrid Nanoconstructs for Cancer Diagnostics and Therapies
    Sergey Mikhailovich Deyev, Ekaterina N. Lebedenko · 2017 · Molecular Biology
63. Engineered nanocarriers for targeted lung cancer therapy: mechanistic innovations and recent clinical progress
    Heayyean Lee, Khadijah Sajid, Jeehoo Lee · 2025 · Exploration of Targeted Anti-tumor Therapy
64. Microbubble-Mediated Delivery for Cancer Therapy
    Richard J. Browning, Eleanor Stride · 2018 · Fluids
65. Intravital Microscopy Imaging Approaches for Image-Guided Drug Delivery Systems
    Dickson K. Kirui, Mauro Ferrari B · 2015 · Current Drug Targets
66. CRISPR delivery systems for organ-specific targeting: Advances and challenges
    Jun Du, Qinjie Wu, Chao Liu, Ning Wang, Changyang Gong · 2025 · Precision medicine and engineering.
67. Tumour-stroma ratio to predict pathological response to neo-adjuvant treatment in rectal cancer
    Maud T. A. Strous, Timothy Faes, Jeroen Heemskerk, Bjorn G.P.M. Lohman, P.C.G. Simons, Maryska L.G. Janssen-Heijnen, F. Jeroen Vogelaar, Adriaan P. De Bruïne A · 2022 · Surgical Oncology
68. A Strategy Utilizing Protein–Protein Interaction Hubs for the Treatment of Cancer Diseases
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69. Synthesis, Positron Emission Tomography Imaging, and Therapy of Diabody Targeted Drug Lipid Nanoparticles in a Prostate Cancer Murine Model
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70. Surface Modifications of Liposomes for Drug Targeting
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71. Nanovectorization of Prostate Cancer Treatment Strategies: A New Approach to Improved Outcomes
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72. Glatiramer acetate enhances tumor retention and innate activation of immunostimulants
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73. Engineered oncolytic bacteria for malignant solid tumor treatment
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74. Tamibarotene-Loaded PLGA Microspheres for Intratumoral Injection Administration: Preparation and Evaluation
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75. Cell and organ drug targeting
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76. Proteins from Lignosus tigris with selective apoptotic cytotoxicity towards MCF7 cell line and suppresses MCF7-xenograft tumor growth
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77. Is antibody-drug conjugate a rising star for clinical treatment of solid tumors? A systematic review and meta-analysis
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78. Complex Effects of Tumor Microenvironment on the Tumor Disposition of carrier-mediated Agents
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79. Recent progress in gemcitabine-loaded nanoparticles for pancreatic cancer therapy: a review
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80. The Evolution and Recent Trends in Acoustic Targeting of Encapsulated Drugs to Solid Tumors: Strategies beyond Sonoporation
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81. АДРЕСНЫЕ БИФУНКЦИОНАЛЬНЫЕ БЕЛКИ И ГИБРИДНЫЕ НАНОСТРУКТУРЫ В ДИАГНОСТИКЕ И ТЕРАПИИ РАКА, "Молекулярная биология"
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82. Poly(N-vinylcaprolactam-co-2-(diethylamino)ethylmethacrylate) coated Fe3O4@SiO2 core-shell magnetic nanoparticles for controlled doxorubicin delivery
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83. Biomimetic microfluidic platform for the quantification of transient endothelial monolayer permeability and therapeutic transport under mimicked cancerous conditions
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84. Nanotechnology-based immunotherapies to combat cancer metastasis
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85. MIX2: A Novel Natural Multi-Component Modulator of Multidrug-Resistance and Hallmarks of Cancer Cells
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86. Multi-drug sequential release systems: Construction and application for synergistic tumor treatment
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87. Biomimetic Nanoparticles for the Treatment of Hematologic Malignancies
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88. Stromal Barrier-Dismantled Nanodrill-Like and Cancer Cell-Targeted pH-Responsive Polymeric Micelles for Further Enhancing the Anticancer Efficacy of Doxorubicin
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89. Magnetic nanoparticle clusters radiosensitise human nasopharyngeal and lung cancer cells after alternating magnetic field treatment
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90. In situ forming implants exposed to ultrasound enhance therapeutic efficacy in subcutaneous murine tumors
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91. Heavily Gd-Doped Non-Toxic Cerium Oxide Nanoparticles for MRI Labelling of Stem Cells
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94. Dose optimization in cancer drug development: Review and outcome of a multi-stakeholder workshop
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95. Application of Convection-Enhanced Drug Delivery in the Treatment of Malignant Gliomas
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96. Nanomicellar Lenalidomide–Fenretinide Combination Suppresses Tumor Growth in an MYCN Amplified Neuroblastoma Tumor
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97. Hypoxia Boosts Aerobic Glycolysis in Carcinoma: A Complex Process for Tumour Development
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98. Deepened cellular/subcellular interface penetration and enhanced antitumor efficacy of cyclic peptidic ligand-decorated accelerating active targeted nanomedicines
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99. EGFR-targeted bacteriophage lambda penetrates model stromal and colorectal carcinoma tissues, is taken up into carcinoma cells, and interferes with 3-dimensional tumor formation
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100. Nanotechnology in Hematology: Enhancing Therapeutic Efficacy With Nanoparticles
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