Drug Induced Liver Injury by Prophylactic Administration of Albendazole
Open accessAbstract
Albendazole is used as a typical antiparasitic agent worldwide. The side effects of albendazole may include nausea, vomiting, abdominal pain, dizziness, headache, alopecia, and increased liver enzymes. Mild elevation of the liver enzyme has been reported in more than 10% of cases, but drug induced liver injury was reported to be very rare. A 30-year-old woman visited the Dong-A University Hospital with anorexia, nausea, jaundice, and elevated liver enzyme. For diagnosis, other acute hepatitis etiologies were excluded, but the prophylactic administration of albendazole was verified. This paper introduces a case of drug-induced liver injury through the prophylactic administration of albendazole. Physicians should be aware of severe liver injury as one of the side effects of albendazole.
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When albendazole and mebendazole are used for prolonged periods to treat tissue helminthiases, cancers, or even once as preventive chemotherapy for intestinal helminths, liver toxicity, allergic reactions, and rarely severe myelosuppression (in particular, neutropenia) may occur.
“However, when these drugs are used for prolonged periods to treat tissue helminthiases [36], cancers [37,38], or even when they are used just for once as preventive chemotherapy for intestinal helminths [39], liver toxicity, allergic reactions, and rarely severe myelosuppression (in particular, neutropenia) may occur.”
From Albendazole and Mebendazole as Anti-Parasitic and Anti-Cancer Agents: an Update (2021) · cites this paper as [39]
Even a single dose treatment of albendazole (400 mg) could cause acute liver toxicity in adult patients as well as in children.
“Notably, however, even a single dose treatment (for empirical or seasonal use) of albendazole (400 mg) could cause acute liver toxicity in adult patients [39,314–318] as well as in children [319–322].”
From Albendazole and Mebendazole as Anti-Parasitic and Anti-Cancer Agents: an Update (2021) · cites this paper as [39]
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Albendazole and Mebendazole as Anti-Parasitic and Anti-Cancer Agents: an Update
Chai, J.-Y., Jung, B.-K., & Hong, S.-J. (2021) · The Korean Journal of Parasitology · doi:10.3347/kjp.2021.59.3.189 · Cited by 286 · see citing works
- Authors
- Moon, S. Y., Baek, Y. H., & Lee, S. W.
- Affiliations
- Dong-A University Hospital (KR)
- Corresponding author
- Lee, Sung Wook
- Venue
- The Korean Journal of Gastroenterology
- Published
- 2019
- Volume
- 73
- Issue
- 6
- Pages
- 360
- ISSN
- 1598-9992 (ISSN-L)
- 2233-6869
- OpenAlex
- W2953561980
- Cited by
- 12
- References
- 0
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2023: 2 · 2022: 1 · 2021: 3 · 2020: 2
- FWCI
- 1.51
- Type
- journal article
- Language
- ko
- Open access
- gold
- doi.org
- Licence
- Locations
- Korean Journal of Gastroenterology (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Drug-Induced Hepatotoxicity and Protection
- Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Pharmacovigilance and Adverse Drug Reactions
- Keywords
- drug-induced liver injury, albendazole, prophylactic administration, antiparasitic drugs, hepatotoxicity, elevated liver enzymes, jaundice, adverse drug reactions
- MeSH terms
- Adult, Alanine Transaminase, Anthelmintics, Aspartate Aminotransferases, Female, Humans, Ultrasonography, Albendazole, Chemical and Drug Induced Liver Injury
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