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BAF Complex Enhances Reprogramming of Adult Human Fibroblasts

Singhal, Nishant, J. Arauzo-Bravo, Marcos·2016·Journal of Stem Cell Research & Therapy
DOI 10.4172/2157-7633.1000336
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Crossref · 10.4172/2157-7633.1000336

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  • During full reprogramming, OCT4 directly recruits the BAF chromatin remodeling complex to promote a euchromatic chromatin state that enhances reprogramming factor binding.

    “First, OCT4 directly recruits the BAF chromatin remodeling complex to promote a euchromatic chromatin state that enhances reprogramming factor binding [37][38][39] .”

    From Mechanisms, pathways and strategies for rejuvenation through epigenetic reprogramming (2023) · cites this paper as [39]

    The Introduction (page unavailable) says Brg1 favors a euchromatic structure and thereby enhances Oct4 recruitment; the results section reports that Brg1 and Baf155 improve reprogramming. The source does not say that OCT4 directly recruits the BAF complex. That reverses the recruitment relationship described in the Introduction. (LLM, conf=0.87)

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Research works printed but not linked: 33

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Metadata

Authors
Singhal, N., & J. Arauzo-Bravo, M.
Venue
Journal of Stem Cell Research & Therapy
Publisher
OMICS Publishing Group
Published
2016
Volume
06
Issue
04
ISSN
2157-7633
DOI
10.4172/2157-7633.1000336
Cited by
5
References
2

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