Pharmacokinetic Modeling of Data with Below Quantification Limit
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Concentration data below LOQ but not below LOD were included to evaluate the excretion profile because inclusion can result in a better fit and excluding or replacing them with zero could lead to biased pharmacokinetic parameters.
“Concentration data below the LOQ (but not below the LOD) were included to evaluate the excretion profile, as their inclusion can result in a better fit of the excretion profile model, while excluding or replacing them with zero could lead to biased pharmacokinetic parameters [39,40,41,42].”
From Urinary Elimination of Ecdysterone and its Metabolites following a Single-Dose Administration in Humans (2021) · cites this paper as [40]
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References 1 · Cited by 7
- Authors
- Dorababunn, M.
- Affiliations
- University of Tennessee Health Science Center (US)
- Corresponding author
- Dorababunn, Madhura
- Venue
- Journal of Bioequivalence & Bioavailability
- Publisher
- OMICS Publishing Group
- Published
- 2012
- Volume
- 04
- Issue
- 02
- ISSN
- 0975-0851 (ISSN-L)
- OpenAlex
- W2320405080
- Cited by
- 7
- References
- 1
- Citations by year
- 2024: 1 · 2022: 1 · 2021: 1 · 2020: 1 · 2019: 1 · 2014: 1 · 2013: 1
- FWCI
- 0.61
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Bioequivalence & Bioavailability (publishedVersion)
- Topics
- Physical Sciences › Mathematics › Statistics and Probability › Statistical Methods in Clinical Trials
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmaceutical studies and practices
- Life Sciences › Immunology and Microbiology › Immunology › Biosimilars and Bioanalytical Methods
- Keywords
- pharmacokinetic modeling, bioequivalence
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