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Facing the Noise: Addressing the Endemic Variability in D LCO Testing
Open accessAbstract
Single-breath diffusing capacity of the lung for carbon monoxide (D(LCO)) is a common pulmonary function test that measures the ability of the lung to exchange gas across the alveolar-capillary interface. D(LCO) testing is used to narrow the differential diagnosis of obstructive and restrictive lung disease, to aid in disability and transplant assessment, and to monitor medication toxicity. The variability in the measurement limits the utility of the test. Variability is attributable to differences in equipment, testing conditions, patient factors, and reference equations. Laboratories can minimize variability by ensuring that equipment meets recommended standards, implementing effective quality control programs, standardizing testing conditions and testing procedures, and accounting for pertinent patient characteristics.
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The incongruity of increased FVC with stable DLCO may be attributed to low numbers of patients in each treatment arm and the inherent variability of DLCO measurement.
“The incongruity of increased FVC with stable DLCO may be attributed to low numbers of patients in each treatment arm and the inherent variability of DLCO measurement41.”
From A generative AI-discovered TNIK inhibitor for idiopathic pulmonary fibrosis: a randomized phase 2a trial (2025) · cites this paper as [41]
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Xu, Z., Ren, F., Wang, P., Cao, J., Tan, C., Ma, D., Zhao, L., Dai, J., Ding, Y., Fang, H., et al. (2025) · Nature Medicine · doi:10.1038/s41591-025-03743-2 · Cited by 180
“The incongruity of increased FVC with stable DLCO may be attributed to low numbers of patients in each treatment arm and the inherent variability of DLCO measurement 41 .”
Metadata
- Authors
- McCormack, M. C.
- Affiliations
- Johns Hopkins University (US)
- Corresponding author
- McCormack, Meredith C
- Venue
- Respiratory Care
- Publisher
- SAGE Publications
- Published
- 2012-01-01
- Volume
- 57
- Issue
- 1
- Pages
- 17-25
- ISSN
- 0020-1324 (ISSN-L)
- OpenAlex
- W2163958514
- Cited by
- 22
- References
- 0
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 2 · 2023: 2 · 2022: 4 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 3 · 2016: 1 · 2015: 1 · 2014: 1 · 2012: 1
- FWCI
- 0.77
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Respiratory Care (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Environmental Health Sciences (K23ES016819)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
- Health Sciences › Health Professions › Medical Laboratory Technology › Clinical Laboratory Practices and Quality Control
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Keywords
- diffusing capacity for carbon monoxide, measurement noise, pulmonary function tests, quality control, reference equations, equipment standards, patient factors, obstructive lung disease, restrictive lung disease, pre-transplant evaluation, disability assessment
- MeSH terms
- Carbon Dioxide, Humans, Lung Diseases, Lung Diseases, Obstructive, Pulmonary Diffusing Capacity, Quality Control, Reference Values, Reproducibility of Results, Lung Diseases, Interstitial
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