Sleep-Disordered Breathing and Cardiovascular Disorders
Open accessAbstract
Compelling data demonstrate a strong association between sleep-disordered breathing (SDB) and cardiovascular disorders. The association is most consistent between obstructive sleep apnea (OSA) and hypertension. Epidemiologic and clinic-based studies provide evidence for an etiological role of OSA in hypertension, independent of obesity. Furthermore, several studies suggest amelioration of hypertension with therapy for sleep apnea. Emerging data also suggest a role for OSA in causing coronary artery disease. This association is bolstered by evidence suggesting that continuous positive airway pressure (CPAP) therapy improves early signs of atherosclerosis and may impede progression to clinically important cardiovascular disease. SDB (both OSA and central sleep apnea) is frequently observed in patients with heart failure. OSA may be a risk factor for incident heart failure. The current data do not provide consistent evidence for whether treatment of SDB will improve survival or other end points in patients with heart failure, and larger trials are currently underway to better elucidate that relationship. Substantial evidence also links SDB to an increased risk of various arrhythmias. Treatment of SDB with CPAP appears to significantly attenuate that risk. Finally, several studies suggest SDB as a risk factor for stroke. Whether treatment of SDB reduces stroke risk, however, remains to be determined. In conclusion, persuasive data provide evidence for an association, probably cau…
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There is a very high prevalence of OSA in those with coronary artery disease, hypertension, heart failure, arrhythmias, and especially atrial fibrillation.
“There is a very high prevalence of OSA in those with CAD, hypertension, HF, arrhythmias, and especially AF.109–112”
From International Consensus Statement on Obstructive Sleep Apnea (2023) · cites this paper as [109]
Patients with untreated OSA may be at increased risk of developing cardiovascular disease, including difficult-to-control blood pressure, coronary artery disease, congestive heart failure, arrhythmias and stroke.
“Patients with untreated OSA may be at increased risk of developing cardiovascular disease, including difficult-to-control blood pressure, coronary artery disease, congestive heart failure, arrhythmias and stroke.16”
From Clinical Practice Guideline for Diagnostic Testing for Adult Obstructive Sleep Apnea: An American Academy of Sleep Medicine Clinical Practice Guideline (2017) · cites this paper as [16]
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References 98 · Cited by 127
- Authors
- Budhiraja, R., Budhiraja, P., & Quan, S. F.
- Affiliations
- Brigham and Women's Hospital (US)
- University of Arizona (US)
- Corresponding author
- Quan, Stuart F
- Venue
- Respiratory Care
- Publisher
- SAGE Publications
- Published
- 2010-10
- Volume
- 55
- Issue
- 10
- Pages
- 1322-1332
- ISSN
- 0020-1324 (ISSN-L)
- PMC
- PMC2972194
- OpenAlex
- W2140060973
- Cited by
- 127
- References
- 98
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 7 · 2023: 9 · 2022: 10 · 2021: 5 · 2020: 8 · 2019: 6 · 2018: 8 · 2017: 6 · 2016: 5 · 2015: 6 · 2014: 9 · 2013: 8 · 2012: 18
- FWCI
- 8.67
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Respiratory Care (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- PubMed
- Funders
- National Heart, Lung, and Blood Institute (U01HL053938, U01HL068060)
- Topics
- Health Sciences › Medicine › Physiology › Obstructive Sleep Apnea Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Health Sciences › Medicine › Pharmacology › Apelin-related biomedical research
- Keywords
- sleep-disordered breathing, obstructive sleep apnea, central sleep apnea, cardiovascular disease, hypertension, coronary artery disease, atherosclerosis, heart failure, cardiac arrhythmias, stroke risk, continuous positive airway pressure, obesity
- MeSH terms
- Cardiovascular Diseases, Humans, Sleep Apnea Syndromes, Risk Reduction Behavior, Continuous Positive Airway Pressure
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