DHA and EPA Down-regulate COX-2 Expression through Suppression of NF-κB Activity in LPS-treated Human Umbilical Vein Endothelial Cells

Lee, Soon Ae; Kim, Hye Jung; Chang, Ki Churl; Baek, Jong Chul; Park, Ji Kwon; Shin, Jeong Kyu; Choi, Won Jun; Lee, Jong Hak; Paik, Won Young

doi:10.4196/kjpp.2009.13.4.301

DHA and EPA Down-regulate COX-2 Expression through Suppression of NF-κB Activity in LPS-treated Human Umbilical Vein Endothelial Cells

Inflammatory processes of vascular endothelial cells play a key role in the development ofatherosclerosis. We determined the anti-inflammatory effects and mechanisms of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) on LPS-treated human umbilical vein endothelial cells (HUVECs) to eva…