Cited by 6Pancreatic function and diabetesDiabetes Management and ResearchDiabetes and associated disorders

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Mathematical Model for the Dynamics of Glucose, Insulin and β-Cell Mass under the Effect of Trauma, Excitement and Stress

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Mohammed, Isa Ibrahim, Adamu, Ibrahim Isa, Barka, Seni James·2019·Modeling and Numerical Simulation of Material Science

Abstract

In this work, we presented a mathematical model for the dynamics of glucose, insulin and beta-cell mass under the influence of trauma, excitement and/or stress, the model is an improvement on the work by [1]. We defined and incorporated a parameter to represent the effectiveness of epinephrine in suppressing insulin secretion and a parameter Ge representing epinephrine induced glucose increase as the factors that affect glucose and insulin homeostasis. The model which consists of a system of three nonlinear ordinary differential equations was used to investigate the effect of epinephrine on glucose, insulin and beta-cell mass dynamics. The result of the study showed that; In the presence of epinephrine, the blood glucose increased and the blood insulin decreased due to suppression by the hormone, despite the fact that there is an increase in beta-cell mass the system remained extremely hyperglycemic. Furthermore, the result of the numerical experiment carried out indicated that frequent epinephrine secretion into the blood induced prolong and extreme hyperglycemia. Frequent epinephrine secretion increases the risk of diabetes in humans. In view of the findings of this study, we recommend that there should be massive and continuous health education, especially for communities living in the areas where the stated agents (trauma, excitement and stress) of epinephrine secretion are common.

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References 5 · Cited by 6

Research works printed but not linked: 2

  1. Frank, N. and Mingxian, J. (2015) Mathematical Modelling and Simulations of the Pathophysiology of Type 2 Diabetes Mellitus. 8th International Conference on Biomedical Engineering and Informatics, Shenyang, 14-16 October 2015, 296-300. · DOI
  2. Ibrahim, I.A., Haruna, Y. and Garba, E.J.D. (2014) Mathematical Model for the Dynamics of Glucose Regulatory System under the Combined Effect of Dieting and Physical Activity. International Journal of Pure and Applied Science and Technology, 20, 88-100.

Metadata

Authors
Mohammed, I. I., Adamu, I. I., & Barka, S. J.
Affiliations
  • Gombe State College of Health Sciences and Technology Kaltungo (NG)
  • Modibbo Adama University of Technology (NG)
Venue
Modeling and Numerical Simulation of Material Science
Published
2019
Volume
09
Issue
04
Pages
71-96
ISSN
  • 2164-5345 (ISSN-L)
  • 2164-5353
OpenAlex
W2976678218
Cited by
6
References
5
Citations by year
2024: 1 · 2023: 2 · 2022: 1 · 2021: 1 · 2020: 1
FWCI
0.72
Type
journal article
Language
en
Open access
Locations
Modeling and Numerical Simulation of Material Science (publishedVersion, cc-by)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
Keywords
epinephrine, hyperglycemia, stress, trauma (physical injury), diabetes risk, glucose homeostasis, nonlinear ordinary differential equations

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CoChat. (2026). Citation check: Mathematical Model for the Dynamics of Glucose, Insulin and β-Cell Mass under the Effect of Trauma, Excitement and Stress. https://app.cochat.ai/papers/10.4236/mnsms.2019.94005
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Mohammed, I. I., Adamu, I. I., & Barka, S. J. (2019). Mathematical Model for the Dynamics of Glucose, Insulin and β-Cell Mass under the Effect of Trauma, Excitement and Stress. Modeling and Numerical Simulation of Material Science. https://doi.org/10.4236/mnsms.2019.94005