Steroid hyperglycemia: Prevalence, early detection and therapeutic recommendations: A narrative review
Open accessAbstract
Steroids are drugs that have been used extensively in a variety of conditions. Although widely prescribed for their anti-inflammatory and immunosuppressive properties, glucocorticoids have several side effects, being hyperglycemia one of the most common and representative. In the present review, we discuss the main epidemiologic characteristics associated with steroid use, with emphasis on the identification of high risk populations. Additionally we present the pathophysiology of corticosteroid induced hyperglycemia as well as the pharmacokinetics and pharmacodynamics associated with steroid use. We propose a treatment strategy based on previous reports and the understanding of the mechanism of action of both, the different types of glucocorticoids and the treatment options, in both the ambulatory and the hospital setting. Finally, we present some of the recent scientific advances as well as some options for future use of glucocorticoids.
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Steroids are the main cause of drug-induced hyperglycaemia.
“steroids are the main cause of drug-induced hyperglycaemia6”
The limited evidence available does not adequately inform the physician about management of hyperglycaemia in patients with DM undergoing glucocorticoid therapy.
“and the limited evidence available does not adequately inform the physician.6”
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References 41 · Cited by 387
Research works printed but not linked: 3
- Tamez-Perez HE, Gutierrez-Hermosillo H, Cedillo-Rodriguez JA, Mora-Torres N, Hernandez-Coria M, Gomez-de-Osio M. Tratamiento con insulina en el paciente hospitalizado con diabetes mellitus tipo 2 Única opción? Med Int Mex 2007; 23:196-199
- Galofre JC. Manejo de los corticoides en la práctica clínica. Rev Med Univ Navarra 2009; 53: 9-18 27
- Tamez-Perez HE, Dolores-Gómez M, Tamez AL, Quintanilla DL, Cisneros-Franco JM, Hernandez-Coria MI. Inhibidores DPP-4 en el tratamiento de la hiperglucemia inducida por el uso crónico de esteroides. Revista de Endocrinología y Nutrición 2011; 19: 102-105
- Authors
- Tamez-Pérez, H. E.
- Affiliations
- Universidad Autónoma de Nuevo León (MX)
- Corresponding author
- Tamez-Pérez, Héctor Eloy
- Venue
- World Journal of Diabetes
- Publisher
- Baishideng Publishing Group Inc.
- Published
- 2015
- Volume
- 6
- Issue
- 8
- Pages
- 1073
- ISSN
- 1948-9358 (ISSN-L)
- PMC
- PMC4515447
- OpenAlex
- W2411105639
- Cited by
- 387
- References
- 41
- Citations by year
- 2026: 30 · 2025: 38 · 2024: 53 · 2023: 47 · 2022: 59 · 2021: 67 · 2020: 34 · 2019: 23 · 2018: 19 · 2017: 11 · 2016: 6
- FWCI
- 1.81
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by-nc
- Locations
- World Journal of Diabetes (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Keywords
- steroid-induced hyperglycemia, glucocorticoids, corticosteroid adverse effects, prevalence, early detection, vulnerable populations, pathophysiology, pharmacokinetics, pharmacodynamics, diabetes management
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