Phase I/II randomized controlled trial of autologous bone marrow-derived mesenchymal stem cell therapy for chronic stroke
Open accessAbstract
AIM: To examine the safety and efficacy of mesenchymal stem cell (MSC) therapy for intracerebral haemorrhage with neurological dysfunctions for a year. METHODS: week upon completion of the treatment. RESULTS: tumour development among patients after monitoring for a year post MSC therapy. Neuro-restoration and clinical improvement in terms of modified Barthel index, functional independence measure and extended Glasgow Outcome Scale were evident among patients having MSC therapy compared to patients receiving placebos. CONCLUSION: Intravenous administration of autologous bone marrow-derived MSC is safe and has the potential of improving neurological functions in chronic stroke patients with severe disability.
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MSC transplantation for acute stroke improves patient symptoms and promotes neurological recovery in ischemic stroke patients without adverse effects.
“MSC transplantation for acute stroke improves patient symptoms and promotes neurological recovery in ischemic stroke patients without adverse effects.360–362”
From Inflammation and aging: signaling pathways and intervention therapies (2023) · cites this paper as [361]
The Abstract (Results and Conclusion) reports neurological improvement after MSC therapy and no observed adverse events during administration or the reported follow-up. But the trial studied patients with chronic stroke one year after intracerebral haemorrhage, not patients with acute ischemic stroke; it therefore does not establish the claim for that population. (LLM, conf=0.90)
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References 41 · Cited by 49
- Authors
- Tsang, K. S., Ng, C. P. S., Zhu, X. L., Wong, G. K. C., Lu, G., Ahuja, A. T., Wong, K. S. L., Ng, H. K., & Poon, W. S.
- Affiliations
- Chinese University of Hong Kong (HK)
- Corresponding author
- Poon, Wai Sang
- Venue
- World Journal of Stem Cells
- Publisher
- Baishideng Publishing Group Inc.
- Published
- 2017
- Volume
- 9
- Issue
- 8
- Pages
- 133
- ISSN
- 1948-0210 (ISSN-L)
- PMC
- PMC5583532
- OpenAlex
- W2746968067
- Cited by
- 49
- References
- 41
- Citations by year
- 2026: 6 · 2025: 6 · 2024: 3 · 2023: 3 · 2022: 8 · 2021: 8 · 2020: 8 · 2019: 3 · 2018: 4
- FWCI
- 2.36
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc
- Locations
- World Journal of Stem Cells (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Funders
- University of Hong Kong
- Hospital Authority
- Chinese University of Hong Kong
- Topics
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Health Sciences › Medicine › Rehabilitation › Stroke Rehabilitation and Recovery
- Health Sciences › Medicine › Pathology and Forensic Medicine › Spinal Cord Injury Research
- Keywords
- mesenchymal stem cells, autologous bone marrow-derived stem cells, chronic stroke, neurological recovery, functional independence, treatment efficacy and safety, carcinogenesis, intracerebral hemorrhage, stroke rehabilitation
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