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Protective effects of asiaticoside on sepsis-induced acute kidney injury in mice
Abstract
Objective The present study is to investigate the protective effects of asiaticoside on sepsis-induced acute kidney injury in mice. Method With the sepsis induced by cecal ligation and puncture (CLP), forty eight kunming mice were randomly divided into four groups as sham operated, CLP treated, CLP + asiaticoside 15, 45 mg x kg(-1) groups. General conditions and the amount of dead rate of mice were observed. The BUN and Cr levels were observed by the kits. IL-6 in serum was assayed by enzyme-linked immunosorbent assay (ELISA). Kidney tissues were harvested for determination of iNOS expression by Western blotting analysis. The pathologic changes were observed under electron microscope via hematoxylin-eosin (HE) stain. Result Compared with CLP group, the death rate, the levels of BUN, Cr, IL-6, and iNOS protein expression of asiaticoside groups were significantly reduced. The pathologic changes in kidney tissues induced by sepsis were significantly attenuated dose-dependently by asiaticoside under electron microscope. Conclusion Asiaticoside has protective effects against sepsis-induced acute kidney injury, which were probably associated with the inhibition of IL-6 in serum and iNOS protein in kidney tissues.
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“Asiaticoside also shows protective effects against sepsis‐induced acute kidney injury by inhibiting inflammation.”
From Therapeutic Properties and Pharmacological Activities of Asiaticoside and Madecassoside: A Review (2023) · cites this paper as [131]
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Therapeutic Properties and Pharmacological Activities of Asiaticoside and Madecassoside: A Review
Bandopadhyay, S., Mandal, S., Ghorai, M., Jha, N. K., Kumar, M., Radha, Ghosh, A., Proćków, J., Pérez de la Lastra, J. M., & Dey, A. (2023) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.17635 · Cited by 220
Metadata
- Authors
- Jiajia, Z.
- Affiliations
- Chongqing Medical University (CN)
- Corresponding author
- Jiajia, ZHENG
- Venue
- China Journal of Chinese Materia Medica
- Published
- 2010-06-01
- Volume
- 35
- Issue
- 11
- Pages
- 1482-5
- ISSN
- 1001-5302 (ISSN-L)
- OpenAlex
- W2366210674
- Cited by
- 4
- References
- 0
- Citations by year
- 2023: 2 · 2022: 1 · 2014: 1
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- China Journal of Chinese Materia Medica (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Nephrology › Acute Kidney Injury Research
- Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Sepsis Diagnosis and Treatment
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Chemotherapy-induced organ toxicity mitigation
- Keywords
- asiaticoside, sepsis, acute kidney injury, cecal ligation and puncture, interleukin-6, inducible nitric oxide synthase, renal protection, kidney histopathology
- MeSH terms
- Animals, Disease Models, Animal, Female, Humans, Male, Plant Extracts, Random Allocation, Triterpenes, Sepsis, Mice, Acute Kidney Injury
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Cite CoChat for the checks on this page, and the paper for its own findings.
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- CoChat. (2026). Citation check: Protective effects of asiaticoside on sepsis-induced acute kidney injury in mice. https://app.cochat.ai/papers/10.4268/cjcmm20101127
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- Jiajia, Z. (2010). Protective effects of asiaticoside on sepsis-induced acute kidney injury in mice. China Journal of Chinese Materia Medica. https://doi.org/10.4268/cjcmm20101127
