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Review of Mass Drug Administration for Malaria and Its Operational Challenges
Open accessAbstract
Mass drug administration (MDA) was a component of many malaria programs during the eradication era, but later was seldomly deployed due to concerns regarding efficacy and feasibility and fear of accelerating drug resistance. Recently, however, there has been renewed interest in the role of MDA as an elimination tool. Following a 2013 Cochrane Review that focused on the quantitative effects of malaria MDA, we have conducted a systematic, qualitative review of published, unpublished, and gray literature documenting past MDA experiences. We have also consulted with field experts, using their historical experience to provide an informed, contextual perspective on the role of MDA in malaria elimination. Substantial knowledge gaps remain and more research is necessary, particularly on optimal target population size, methods to improve coverage, and primaquine safety. Despite these gaps, MDA has been used successfully to control and eliminate Plasmodium falciparum and P. vivax malaria in the past, and should be considered as part of a comprehensive malaria elimination strategy in specific settings.
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Citations
Cited by
“Asymptomatic” Malaria: A Chronic and Debilitating Infection That Should Be Treated
Chen, I., Clarke, S. E., Gosling, R., Hamainza, B., Killeen, G., Magill, A., O’Meara, W., Price, R. N., & Riley, E. M. (2016) · PLOS Medicine · doi:10.1371/journal.pmed.1001942 · Cited by 386
Self-citationHemingway, J., Shretta, R., Wells, T. N. C., Bell, D., Djimdé, A. A., Achee, N., & Qi, G. (2016) · PLOS Biology · doi:10.1371/journal.pbio.1002380 · Cited by 293
Metadata
- Authors
- Newby, G., Hwang, J., Koita, K., Chen, I., Greenwood, B., von Seidlein, L., Shanks, G. D., Slutsker, L., Kachur, S. P., Wegbreit, J., Ippolito, M. M., Poirot, E., & Gosling, R.
- Venue
- The American Society of Tropical Medicine and Hygiene
- Published
- 2015-07-08
- Volume
- 93
- Issue
- 1
- Pages
- 125-134
- ISSN
- 0002-9637 (ISSN-L)
- 1476-1645
- OpenAlex
- W2114625697
- Cited by
- 222
- References
- 0
- FWCI
- 23.29
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Review of Mass Drug Administration for Malaria and Its Operational Challenges. https://app.cochat.ai/papers/10.4269/ajtmh.14-0254
- The paper
- Newby, G., Hwang, J., Koita, K., Chen, I., Greenwood, B., von Seidlein, L., Shanks, G. D., Slutsker, L., Kachur, S. P., Wegbreit, J., Ippolito, M. M., Poirot, E., & Gosling, R. (2015). Review of Mass Drug Administration for Malaria and Its Operational Challenges. The American Society of Tropical Medicine and Hygiene. https://doi.org/10.4269/ajtmh.14-0254
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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