Ackee Fruit Poisoning in Eight Siblings: Implications for Public Health Awareness
Open accessAbstract
Ackee apple fruit is a native fruit to Jamaica and some parts of west Africa. Its toxicity known as "Jamaican vomiting sickness" dates back to the nineteenth century. However, there is a dearth of reported published data on toxicity from Nigeria where it is popularly known in the southwest as "ishin." We report a case series of eight previously well Nigerian siblings who presented at various intervals after ingestion of roasted seeds and aril of the ackee fruit.
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Jamaican vomiting sickness/toxic hypoglycemic syndrome is characterized by hypoglycemia, acidemia, liver injury, and severe vomiting, and in severe cases has led to seizures, coma, or death.
“Jamaican vomiting sickness/toxic hypoglycemic syndrome, characterized by hypoglycemia, acidemia, liver injury, and severe vomiting. In severe cases, it has led to seizures, coma, or death [114]”
From Non-Diabetic Hypoglycemia: Evaluation and Management in Adults (2025) · cites this paper as [114]
Unripe ackee fruit contains hypoglycin A and B, which are metabolized into MCPA, which inhibits fatty acid oxidation and impairs gluconeogenesis.
“Hypoglycin Aand B are metabolized into MCPA *, which inhibits fatty acid oxidation and impairs gluconeogenesis [114]”
From Non-Diabetic Hypoglycemia: Evaluation and Management in Adults (2025) · cites this paper as [114]
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Non-Diabetic Hypoglycemia: Evaluation and Management in Adults
Looi, E., & Lawler, H. M. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14134393 · Cited by 10 · see citing works
- Authors
- Katibi, O. S., Olaosebikan, R., Abdulkadir, M. B., Ogunkunle, T. O., Ibraheem, R. M., & Murtala, R.
- Affiliations
- University of Ilorin (NG)
- Corresponding author
- Katibi, Oludolapo Sherifat
- ORCID
- Venue
- The American Society of Tropical Medicine and Hygiene
- Published
- 2015-11-04
- Volume
- 93
- Issue
- 5
- Pages
- 1122-1123
- ISSN
- 0002-9637 (ISSN-L)
- 1476-1645
- PMC
- PMC4703256
- OpenAlex
- W2279192790
- Cited by
- 22
- References
- 0
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2023: 2 · 2021: 1 · 2020: 6 · 2019: 2 · 2018: 1 · 2017: 5 · 2016: 1
- FWCI
- 1.01
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- American Journal of Tropical Medicine and Hygiene (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Plant Toxicity and Pharmacological Properties
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Plant-based Medicinal Research
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Cassava research and cyanide
- Keywords
- siblings, food poisoning, public health awareness, Nigeria
- MeSH terms
- Child, Child, Preschool, Female, Fruit, Humans, Nigeria, Plant Poisoning, Public Health, Seeds, Blighia, Siblings
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