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Epidemiologic, Clinical, and Virologic Observations on Dengue in the Kingdom of Tonga
Abstract
An outbreak of dengue type 2 infection occurred in the Pacific island Kingdom of Tonga in 1974 and an outbreak of dengue type 1 occurred there in 1975. The 1974 outbreak was characterized by relatively mild clinical disease with few hemorrhagic manifestations, a low attack rate, and relatively low viremia levels. The 1975 outbreak was characterized by relatively severe disease with frequent hemorrhagic manifestations and a high attack rate. The differences between the outbreaks could not be attributed to differences in abudance of, or susceptibility to infection of, mosquito vectors or to the prior immune status or other characteristics of the human population. It appeared that a difference in viral virulence was the most likely explanation.
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Citations
Cited by
Mackenzie, J. S., Gubler, D. J., & Petersen, L. R. (2004) · Nature Medicine · doi:10.1038/nm1144 · Cited by 1,314
Self-citationDengue, Urbanization and Globalization: The Unholy Trinity of the 21st Century
Gubler, D. J. (2011) · Tropical Medicine and Health · doi:10.2149/tmh.2011-s05 · Cited by 1,098
Self-citationDengue and dengue haemorrhagic fever
Rigau-Pérez, J. G., Clark, G. G., Gubler, D. J., Reiter, P., Sanders, E. J., & Vance Vorndam, A. (1998) · The Lancet · doi:10.1016/s0140-6736(97)12483-7 · Cited by 1,051
Self-citationDengue Virus–Mosquito Interactions
Halstead, S. B. (2008) · Annual Review of Entomology · doi:10.1146/annurev.ento.53.103106.093326 · Cited by 438
Selection-driven evolution of emergent dengue virus.
Bennett, S. N. (2003) · Molecular Biology and Evolution · doi:10.1093/molbev/msg182 · Cited by 204
Metadata
- Authors
- Gubler, D. J., Reed, D., Rosen, L., & Hitchcock, J. C.
- Venue
- The American Journal of Tropical Medicine and Hygiene
- Published
- 1978-05
- Volume
- 27
- Issue
- 3
- Pages
- 581-589
- ISSN
- 0002-9637 (ISSN-L)
- OpenAlex
- W1832226853
- Cited by
- 207
- References
- 0
- FWCI
- 3.81
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Epidemiologic, Clinical, and Virologic Observations on Dengue in the Kingdom of Tonga. https://app.cochat.ai/papers/10.4269/ajtmh.1978.27.581
- The paper
- Gubler, D. J., Reed, D., Rosen, L., & Hitchcock, J. C. (1978). Epidemiologic, Clinical, and Virologic Observations on Dengue in the Kingdom of Tonga. The American Journal of Tropical Medicine and Hygiene. https://doi.org/10.4269/ajtmh.1978.27.581
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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