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Cited by 22Parasites and Host InteractionsHelminth infection and controlParasitic Diseases Research and Treatment

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Single Dose Mebendazole Therapy for Soil-Transmitted Nematodes

Abadi, K.·1985·The American Journal of Tropical Medicine and Hygiene
DOI 10.4269/ajtmh.1985.34.129
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Abstract

Four hundred and fifty subjects were included in a study of the prevalence of soil-transmitted nematodes in Ujung Pandang, South-Sulawesi, Indonesia. Trichuriasis was the most prevalent infection (93.3%), followed by ascariasis (80.2%) and hookworm infection (19.5%). Among 156 subjects who were given 500 mg of mebendazole in a single dose, treatment resulted in cure rates of 93.4%, 77.6%, and 91.1%, and average egg-count reduction rates of 99.0%, 92.8%, and 98.3%, for ascariasis, trichuriasis, and hookworm infections, respectively. Mebendazole appeared to be equally effective against necatoriasis and ancylostomiasis. The drug was well tolerated and almost no side effects were observed. Single dose mebendazole treatment appears to be relatively inexpensive, convenient, and effective in mass treatment for the control of intestinal nematode infections, especially in highly infected communities.

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Metadata

Authors
Abadi, K.
Corresponding author
Abadi, K.
ORCID
Abadi, K.
Venue
The American Journal of Tropical Medicine and Hygiene
Publisher
American Society of Tropical Medicine and Hygiene
Published
1985-01-01
Volume
34
Issue
1
Pages
129-133
ISSN
  • 0002-9637 (ISSN-L)
  • 1476-1645
DOI
10.4269/ajtmh.1985.34.129
OpenAlex
W2337632612
Cited by
22
References
0
Citations by year
2021: 1 · 2018: 1 · 2017: 1 · 2016: 1
FWCI
0.74
Type
journal article
Language
en
Open access
closed
Locations
  • American Journal of Tropical Medicine and Hygiene (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Immunology and Microbiology › Parasitology › Parasites and Host Interactions
  • Life Sciences › Immunology and Microbiology › Parasitology › Helminth infection and control
  • Health Sciences › Medicine › Infectious Diseases › Parasitic Diseases Research and Treatment
Keywords
mebendazole, single-dose therapy, soil-transmitted nematodes, trichuriasis, ascariasis, hookworm infection, intestinal nematode infection, mass drug administration, cure rate, egg count reduction, drug tolerability, prevalence, Makassar
MeSH terms
Ascariasis, Benzimidazoles, Feces, Hookworm Infections, Humans, Mebendazole, Nematode Infections, Parasite Egg Count, Trichuriasis

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