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Detecting Artificial Anti-Dengue IgM Immune Complexes Using an Enzyme-Linked Immunosorbent Assay
Abstract
A variety of methods have been employed to detect viral immune complexes (IC) in clinical specimens. However, most techniques used were not antigen-specific. We developed a simple, specific double antibody sandwich technique to detect artificial anti-dengue (DEN) IgM immune complex (IgM-IC). Positive reactivity with IgM-ICs prepared with live DEN-1, -2, and -3 viruses was found to be related to IgM titers exceeding 1:20 and to the titer of the viruses. Most IgM-ICs prepared with live DEN-4 virus did not react. In contrast, IgM-ICs prepared with hemagglutination antigens, representing all 4 serotypes, reacted positively with amounts of antigens ranging from 2 to 8 units. These IgM-ICs were not type-specific.
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Cited by
Antibody-dependent enhancement of severe dengue disease in humans
Katzelnick, L. C., Gresh, L., Halloran, M. E., Mercado, J. C., Kuan, G., Gordon, A., Balmaseda, A., & Harris, E. (2017) · Science · doi:10.1126/science.aan6836 · Cited by 1,205
Serious adverse events associated with yellow fever 17DD vaccine in Brazil: a report of two cases
Vasconcelos, P. F., Luna, E. J., Galler, R., Silva, L. J., Coimbra, T. L., Barros, V. L., Monath, T. P., Rodigues, S. G., Laval, C., Costa, Z. G., et al. (2001) · The Lancet · doi:10.1016/s0140-6736(01)05326-0 · Cited by 287
Loroño-Pino, M. A., García-Rejón, J. E., Machain-Williams, C., Gomez-Carro, S., Nuñez-Ayala, G., del Rosario Nájera-Vázquez, M., Losoya, A., Aguilar, L., Saavedra-Rodriguez, K., Lozano-Fuentes, S., et al. (2013) · The American Society of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.12-0772 · Cited by 69
Metadata
- Authors
- Kuno, G., Gómez, I., & Gubler, D. J.
- Venue
- The American Journal of Tropical Medicine and Hygiene
- Published
- 1987
- Volume
- 36
- Issue
- 1
- Pages
- 153-159
- ISSN
- 0002-9637 (ISSN-L)
- OpenAlex
- W2463026579
- Cited by
- 175
- References
- 0
- FWCI
- 0.51
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kuno, G., Gómez, I., & Gubler, D. J. (1987). Detecting Artificial Anti-Dengue IgM Immune Complexes Using an Enzyme-Linked Immunosorbent Assay. The American Journal of Tropical Medicine and Hygiene. https://doi.org/10.4269/ajtmh.1987.36.153
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