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Antibody-Dependent Enhancement of Dengue Virus Growth in Human Monocytes as a Risk Factor for Dengue Hemorrhagic Fever
Abstract
Serum specimens collected during a prospective study of dengue infections among schoolchildren in Bangkok were tested for their ability to enhance dengue 2 (DEN-2) virus growth in human monocytes in vitro. Two groups of dengue-immune sera were compared: 32 dengue antibody positive serum specimens from children who subsequently developed asymptomatic secondary dengue infections; and 9 dengue antibody positive serum specimens from children who subsequently developed severe symptomatic secondary dengue infections, 8 of which were clinically diagnosed as dengue hemorrhagic fever. Antibody-dependent enhancement of virus growth was quantitated by measurement of virus yields in supernatant fluids of normal human monocyte cultures that were infected with DEN-2 virus in the presence of undiluted test serum. Only 4 of 32 (12%) preinfection sera from asymptomatic children, but 6 of 9 (67%) preinfection sera from symptomatic children, had significant enhancing activity (P less than 0.001). High serum DEN-2 antibody dependent enhancing activity is a significant (relative risk = 6.2) risk factor for severe illness among children in a dengue hemorrhagic fever endemic region. Dengue antibodies can be neutralizing and therefore protective, or they can be enhancing and increase the risk of dengue hemorrhagic fever.
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Cited by
Dengue Viremia Titer, Antibody Response Pattern, and Virus Serotype Correlate with Disease Severity
Vaughn, D. W., Green, S., Kalayanarooj, S., Innis, B. L., Nimmannitya, S., Suntayakorn, S., Endy, T. P., Raengsakulrach, B., Rothman, A. L., Ennis, F. A., et al. (2000) · The Journal of Infectious Diseases · doi:10.1086/315215 · Cited by 1,632
Self-citationAntibody-dependent enhancement of severe dengue disease in humans
Katzelnick, L. C., Gresh, L., Halloran, M. E., Mercado, J. C., Kuan, G., Gordon, A., Balmaseda, A., & Harris, E. (2017) · Science · doi:10.1126/science.aan6836 · Cited by 1,205
Guzmán, M. G., & Kouri, G. (2002) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(01)00171-2 · Cited by 1,163
Dengue and dengue haemorrhagic fever
Rigau-Pérez, J. G., Clark, G. G., Gubler, D. J., Reiter, P., Sanders, E. J., & Vance Vorndam, A. (1998) · The Lancet · doi:10.1016/s0140-6736(97)12483-7 · Cited by 1,051
Prospects for a dengue virus vaccine
Whitehead, S. S., Blaney, J. E., Durbin, A. P., & Murphy, B. R. (2007) · Nature Reviews Microbiology · doi:10.1038/nrmicro1690 · Cited by 623
Metadata
- Authors
- Kliks, S. C., Nisalak, A., Brandt, W. E., Wahl, L., & Burke, D. S.
- Venue
- The American Journal of Tropical Medicine and Hygiene
- Published
- 1989-04
- Volume
- 40
- Issue
- 4
- Pages
- 444-451
- ISSN
- 0002-9637 (ISSN-L)
- OpenAlex
- W1879379129
- Cited by
- 517
- References
- 0
- FWCI
- 8.73
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Antibody-Dependent Enhancement of Dengue Virus Growth in Human Monocytes as a Risk Factor for Dengue Hemorrhagic Fever. https://app.cochat.ai/papers/10.4269/ajtmh.1989.40.444
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- Kliks, S. C., Nisalak, A., Brandt, W. E., Wahl, L., & Burke, D. S. (1989). Antibody-Dependent Enhancement of Dengue Virus Growth in Human Monocytes as a Risk Factor for Dengue Hemorrhagic Fever. The American Journal of Tropical Medicine and Hygiene. https://doi.org/10.4269/ajtmh.1989.40.444
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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