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Dengue Hemorrhagic Fever in Cuba, 1981: A Retrospective Seroepidemiologic Study
Abstract
In Cuba, 2 epidemics of dengue virus occurred: 1 caused by DEN-1 in 1977 and 1 caused by DEN-2 in 1981. The latter was associated with cases of dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS). To study viral risk factors for DHF/DSS, a retrospective seroepidemiological survey was conducted in Cerro, a densely populated district in Havana City. The prevalence of plaque reduction neutralizing antibodies to DEN-1 and DEN-2 viruses was measured in 1,295 individuals (children and adults). Of these, 43.7% were immune to DEN-1 virus and 23.6% to DEN-2 virus. Of those individuals who were immune, 26.1% were immune to DEN-1 virus only, 6% to DEN-2 virus only, and 17.6% to both viruses. The DEN-2 virus infection rate in DEN-1 immune individuals was 3.8 times higher than in non-immune individuals. The 5 DHF/DSS cases in the sample had evidence of DEN-1 virus plus DEN-2 virus infections. Three were children and 2 were young adults. No cases were found in individuals infected with DEN-1 virus or DEN-2 virus only. Children infected by DEN-1 virus followed by DEN-2 virus had a high risk of acquiring DHF/DSS. Blacks and whites were equally infected with DEN-1 and DEN-2 viruses.
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Cited by
Dengue: a continuing global threat
Guzman, M. G., Halstead, S. B., Artsob, H., Buchy, P., Farrar, J., Gubler, D. J., Hunsperger, E., Kroeger, A., Margolis, H. S., Martínez, E., et al. (2010) · Nature Reviews Microbiology · doi:10.1038/nrmicro2460 · Cited by 2,082
Guzmán, M. G., & Kouri, G. (2002) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(01)00171-2 · Cited by 1,163
Self-citationProspects for a dengue virus vaccine
Whitehead, S. S., Blaney, J. E., Durbin, A. P., & Murphy, B. R. (2007) · Nature Reviews Microbiology · doi:10.1038/nrmicro1690 · Cited by 623
Dengue Virus–Mosquito Interactions
Halstead, S. B. (2008) · Annual Review of Entomology · doi:10.1146/annurev.ento.53.103106.093326 · Cited by 438
Antibody‐dependent enhancement of viral infection: molecular mechanisms and in vivo implications
Takada, A., & Kawaoka, Y. (2003) · Reviews in Medical Virology · doi:10.1002/rmv.405 · Cited by 332
Metadata
- Authors
- Guzmán, M. G., Kouri, G. P., Bravo, J., Soler, M., Vazquez, S., & Morier, L.
- Venue
- The American Journal of Tropical Medicine and Hygiene
- Published
- 1990-02
- Volume
- 42
- Issue
- 2
- Pages
- 179-184
- ISSN
- 0002-9637 (ISSN-L)
- OpenAlex
- W1777213512
- Cited by
- 348
- References
- 0
- FWCI
- 3.70
- Type
- journal article
- Language
- en
- Open access
- closed
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- Guzmán, M. G., Kouri, G. P., Bravo, J., Soler, M., Vazquez, S., & Morier, L. (1990). Dengue Hemorrhagic Fever in Cuba, 1981: A Retrospective Seroepidemiologic Study. The American Journal of Tropical Medicine and Hygiene. https://doi.org/10.4269/ajtmh.1990.42.179
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