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Microvascular Sequestration of Parasitized Erythrocytes in Human Falciparum Malaria: a Pathological Study
Abstract
Thirty-nine falciparum malaria autopsy cases from the Hospital for Tropical Diseases, Mahidol University, Bangkok, Thailand were divided into two groups that had had either cerebral malaria (CM) or non-cerebral malaria (NCM). We then studied significant pathological differences between these groups in order to investigate the correlation between parasitized erythrocyte (PRBC) sequestration in small blood vessels in the brain, heart, lungs and small intestines. We found that the percentage of PRBC sequestration in the organs which we studied was higher in the CM patients than in the NCM patients. The difference of PRBC sequestration among the organs of two groups was significant (P less than 0.05). In the CM group, the average percentage of PRBC sequestration in the brain was significantly higher than in the heart, lungs and small intestines (P less than 0.05). No statistically significant difference was found between PRBC sequestration in the brains, hearts, lungs and small intestines in the NCM group (P greater than 0.05). Our study indicates that severity of malaria in the CM patients depends on PRBC sequestration, especially in the brain. A combination of functional disturbances of the other organs, in addition to the cerebral pathology, may augment the severity of the disease.
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Cited by
Su, X.-Z., Heatwole, V. M., Wertheimer, S. P., Guinet, F., Herrfeldt, J. A., Peterson, D. S., Ravetch, J. A., & Wellems, T. E. (1995) · Cell · doi:10.1016/0092-8674(95)90055-1 · Cited by 1,219
World Health Organization (2000) · Transactions of the Royal Society of Tropical Medicine and Hygiene · doi:10.1016/s0035-9203(00)90300-6 · Cited by 1,085
CLINICAL ASPECTS OF UNCOMPLICATED AND SEVERE MALARIA
Bartoloni, A., & Zammarchi, L. (2012) · Mediterranean Journal of Hematology and Infectious Diseases · doi:10.4084/mjhid.2012.026 · Cited by 304
Scott, J. A. G., Berkley, J. A., Mwangi, I., Ochola, L., Uyoga, S., Macharia, A., Ndila, C., Lowe, B. S., Mwarumba, S., Bauni, E., et al. (2011) · The Lancet · doi:10.1016/s0140-6736(11)60888-x · Cited by 294
Mantel, P.-Y., Hjelmqvist, D., Walch, M., Kharoubi-Hess, S., Nilsson, S., Ravel, D., Ribeiro, M., Grüring, C., Ma, S., Padmanabhan, P., et al. (2016) · Nature Communications · doi:10.1038/ncomms12727 · Cited by 237
Metadata
- Authors
- Pongponratn, E., Riganti, M., Punpoowong, B., & Aikawa, M.
- Venue
- The American Journal of Tropical Medicine and Hygiene
- Published
- 1991-02
- Volume
- 44
- Issue
- 2
- Pages
- 168-175
- ISSN
- 0002-9637 (ISSN-L)
- OpenAlex
- W2403104789
- Cited by
- 307
- References
- 0
- FWCI
- 13.37
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Microvascular Sequestration of Parasitized Erythrocytes in Human Falciparum Malaria: a Pathological Study. https://app.cochat.ai/papers/10.4269/ajtmh.1991.44.168
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- Pongponratn, E., Riganti, M., Punpoowong, B., & Aikawa, M. (1991). Microvascular Sequestration of Parasitized Erythrocytes in Human Falciparum Malaria: a Pathological Study. The American Journal of Tropical Medicine and Hygiene. https://doi.org/10.4269/ajtmh.1991.44.168
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