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Albendazole in the Treatment of Onchocerciasis: Double-Blind Clinical Trial in Venezuela
Abstract
A double-blind clinical trial was conducted in Monagas State, Venezuela to assess the tolerance and efficacy of albendazole in the therapy of Onchocerca volvulus infection. Forty-nine patients (26 treated and 23 controls) received a 10-day course of albendazole (400 mg/day) or a placebo. Consistent with the excellent tolerance observed, albendazole did not kill microfilariae. However, analysis of changes in microfilarial densities (mf/mg of skin) over one year showed that albendazole was active against O. volvulus, presumably by interfering with embryogenesis. The nature, degree, and duration of this effect remain to be determined.
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A prolonged course of albendazole (400 mg daily for 10 days) in 26 patients caused changes in microfilarial densities over a year period, presumably by interfering with embryogenesis, though not directly killing microfilariae.
“A prolonged course of albendazole treatment (400 mg daily for 10 days) in 26 patients caused changes in microfilarial densities over a year period, presumably by interfering with embryogenesis, though not directly killing microfilariae [213]”
From Albendazole and Mebendazole as Anti-Parasitic and Anti-Cancer Agents: an Update (2021) · cites this paper as [213]
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Albendazole and Mebendazole as Anti-Parasitic and Anti-Cancer Agents: an Update
Chai, J.-Y., Jung, B.-K., & Hong, S.-J. (2021) · The Korean Journal of Parasitology · doi:10.3347/kjp.2021.59.3.189 · Cited by 286
Metadata
- Authors
- Cline, B. L., Hernandez, J. L., Mather, F. J., Bartholomew, R., De Maza, S. N., Rodulfo, S., Welborn, C. A., Eberhard, M. L., & Convit, J.
- Affiliations
- Tulane University (US)
- Venue
- The American Journal of Tropical Medicine and Hygiene
- Published
- 1992-10
- Volume
- 47
- Issue
- 4
- Pages
- 512-520
- ISSN
- 0002-9637 (ISSN-L)
- OpenAlex
- W2396365845
- Cited by
- 29
- References
- 0
- Citations by year
- 2026: 1 · 2023: 1 · 2022: 1 · 2021: 1 · 2019: 3 · 2018: 1 · 2017: 1 · 2016: 1 · 2014: 1
- FWCI
- 0.71
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Tropical Medicine and Hygiene (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Parasitic Diseases Research and Treatment
- Life Sciences › Immunology and Microbiology › Parasitology › Parasites and Host Interactions
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Research on Leishmaniasis Studies
- Keywords
- albendazole, onchocerciasis, Onchocerca volvulus, microfilariae, microfilarial density, drug efficacy, drug tolerance, embryonic development, antiparasitic treatment
- MeSH terms
- Adolescent, Adult, Animals, Anterior Chamber, Double-Blind Method, Drug Tolerance, Humans, Male, Microfilariae, Middle Aged, Onchocerciasis, Skin, Venezuela, Albendazole, Onchocerciasis, Ocular, Onchocerca volvulus
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