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A Comparative Trial of a Single-Dose Ivermectin Versus Three Days of Albendazole for Treatment of Strongyloides Stercoralis and Other Soil-Transmitted Helminth Infections in Children
Abstract
A randomized trial carried out in rural Zanzibar comparing a single dose of 200 micrograms/kg of ivermectin and 400 mg/day for three days of albendazole for treatment of strongyloidiasis and other intestinal nematodes is described. In 301 children with Strongyloides stercoralis infection, treatment with ivermectin or albendazole resulted in cure rates of 83% and 45%, respectively. While both drugs were very effective against Ascaris lumbricoides, Trichuris trichiura was cured only in 11% (ivermectin) and 43% (albendazole) of the subjects, although the mean eggload was reduced by 59% and 92%, respectively. Ivermectin was ineffective against hookworms, while albendazole resulted in a cure rate of 98%. No severe side effects were recorded and mild side effects were of transient nature for both treatments. Therefore, ivermectin provides a safe and a highly effective single dose treatment for S. stercoralis and A. lumbricoides, while it is not an alternative for the treatment of T. trichiura and hookworm infections.
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Cited by
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Olsen, A., van Lieshout, L., Marti, H., Polderman, T., Polman, K., Steinmann, P., Stothard, R., Thybo, S., Verweij, J. J., & Magnussen, P. (2009) · Transactions of the Royal Society of Tropical Medicine and Hygiene · doi:10.1016/j.trstmh.2009.02.013 · Cited by 579
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Bisoffi, Z., Buonfrate, D., Montresor, A., Requena-Méndez, A., Muñoz, J., Krolewiecki, A. J., Gotuzzo, E., Mena, M. A., Chiodini, P. L., Anselmi, M., et al. (2013) · PLoS Neglected Tropical Diseases · doi:10.1371/journal.pntd.0002214 · Cited by 313
Vercruysse, J., Behnke, J. M., Albonico, M., Ame, S. M., Angebault, C., Bethony, J. M., Engels, D., Guillard, B., Hoa, N. T. V., Kang, G., et al. (2011) · PLoS Neglected Tropical Diseases · doi:10.1371/journal.pntd.0000948 · Cited by 301
The Drugs We Have and the Drugs We Need Against Major Helminth Infections
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Mass drug administration for scabies control in a population with endemic disease.
Romani, L., Whitfeld, M. J., Koroivueta, J., Kama, M., Wand, H., Tikoduadua, L., Tuicakau, M., Koroi, A., Andrews, R., Kaldor, J. M., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1500987 · Cited by 268
Metadata
- Authors
- Marti, H., Haji, H. J., Savioli, L., Chwaya, H. M., Mgeni, A. F., Ameir, J. S., & Hatz, C.
- Venue
- The American Journal of Tropical Medicine and Hygiene
- Published
- 1996-11
- Volume
- 55
- Issue
- 5
- Pages
- 477-481
- ISSN
- 0002-9637 (ISSN-L)
- OpenAlex
- W2283542633
- Cited by
- 286
- References
- 0
- FWCI
- 3.81
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: A Comparative Trial of a Single-Dose Ivermectin Versus Three Days of Albendazole for Treatment of Strongyloides Stercoralis and Other Soil-Transmitted Helminth Infections in Children. https://app.cochat.ai/papers/10.4269/ajtmh.1996.55.477
- The paper
- Marti, H., Haji, H. J., Savioli, L., Chwaya, H. M., Mgeni, A. F., Ameir, J. S., & Hatz, C. (1996). A Comparative Trial of a Single-Dose Ivermectin Versus Three Days of Albendazole for Treatment of Strongyloides Stercoralis and Other Soil-Transmitted Helminth Infections in Children. The American Journal of Tropical Medicine and Hygiene. https://doi.org/10.4269/ajtmh.1996.55.477
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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