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Efficacy of six doses of artemether-lumefantrine (benflumetol) in multidrug-resistant Plasmodium falciparum malaria.
Abstract
The new oral fixed combination artemether-lumefantrine (CGP 56697) has proved to be an effective and well-tolerated treatment of multi-drug resistant Plasmodium falciparum malaria, although cure rates using the four-dose regimen have been lower than with the currently recommended alternative of artesunate-mefloquine. Two six-dose schedules (total adult dose = 480 mg of artemether and 2,880 mg of lumefantrine) were therefore compared with the previously used four-dose regimen (320 mg of artemether and 1,920 mg of lumefantrine) in a double-blind trial involving 359 patients with uncomplicated multidrug-resistant falciparum malaria. There were no differences between the three treatment groups in parasite and fever clearance times, and reported adverse effects. The two six-dose regimens gave adjusted 28-day cure rates of 96.9% and 99.12%, respectively, compared with 83.3% for the four-dose regimen (P < 0.001). These six-dose regimens of artemether-lumefantrine provide a highly effective and very well-tolerated treatment for multidrug-resistant falciparum malaria.
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Cited by
Price, R. N., Uhlemann, A.-C., van Vugt, M., Brockman, A., Hutagalung, R., Nair, S., Nash, D., Singhasivanon, P., Anderson, T. J. C., Krishna, S., et al. (2006) · Clinical Infectious Diseases · doi:10.1086/503423 · Cited by 317
Self-citationMixed-species malaria infections in humans
Mayxay, M., Pukrittayakamee, S., Newton, P. N., & White, N. J. (2004) · Trends in Parasitology · doi:10.1016/j.pt.2004.03.006 · Cited by 301
Self-citationMcGready, R., Tan, S. O., Ashley, E. A., Pimanpanarak, M., Viladpai-nguen, J., Phaiphun, L., Wüstefeld, K., Barends, M., Laochan, N., Keereecharoen, L., et al. (2008) · PLoS Medicine · doi:10.1371/journal.pmed.0050253 · Cited by 136
Self-citationMcGready, R., Cho, T., Samuel, Villegas, L., Brockman, A., van Vugt, M., Looareesuwan, S., White, N. J., & Nosten, F. (2001) · Transactions of the Royal Society of Tropical Medicine and Hygiene · doi:10.1016/s0035-9203(01)90106-3 · Cited by 114
Self-citationMcGready, R., Brockman, A., Cho, T., Cho, D., van Vugt, M., Luxemburger, C., Chongsuphajaisiddhi, T., White, N. J., & Nosten, F. (2000) · Transactions of the Royal Society of Tropical Medicine and Hygiene · doi:10.1016/s0035-9203(00)90235-9 · Cited by 110
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Metadata
- Authors
- Vugt, M. V., Wilairatana, P., Gemperli, B., Gathmann, I., Phaipun, L., Brockman, A., Luxemburger, C., White, N. J., Nosten, F., & Looareesuwan, S.
- Venue
- The American journal of tropical medicine and hygiene
- Published
- 1999-06
- Volume
- 60
- Issue
- 6
- Pages
- 936-942
- ISSN
- 0002-9637 (ISSN-L)
- OpenAlex
- W2120622726
- Cited by
- 194
- References
- 0
- FWCI
- 13.82
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Efficacy of six doses of artemether-lumefantrine (benflumetol) in multidrug-resistant Plasmodium falciparum malaria. https://app.cochat.ai/papers/10.4269/ajtmh.1999.60.936
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- Vugt, M. V., Wilairatana, P., Gemperli, B., Gathmann, I., Phaipun, L., Brockman, A., Luxemburger, C., White, N. J., Nosten, F., & Looareesuwan, S. (1999). Efficacy of six doses of artemether-lumefantrine (benflumetol) in multidrug-resistant Plasmodium falciparum malaria. The American journal of tropical medicine and hygiene. https://doi.org/10.4269/ajtmh.1999.60.936
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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