TREATMENT OF CUTANEOUS GNATHOSTOMIASIS WITH IVERMECTIN
Abstract
In a randomized open study, we compared the efficacy of a single dose of oral ivermectin (200 μg/kg) and oral albendazole (400 mg/day for 21 days) for the treatment of cutaneous gnathostomiasis. Thirty-one patients were randomly assigned to receive ivermectin (n = 17) or albendazole (n = 14). Thirteen of 17 patients who received ivermectin responded, 3 relapsed, and 1 was unresponsive (cure rate = 76%). Thirteen of 14 patients who received albendazole responded very well and did not relapse. Only one patient was unresponsive (cure rate = 92%; P > 0.05). No major side effects were observed in both groups. We concluded that a single dose of ivermectin (200 μg/kg) is less effective than albendazole (400 mg/day for 21 days) for treatment of cutaneous gnathostomiasis, but there was no statistically significant difference ( P > 0.05).
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Similar results to albendazole were reported using albendazole alone (same regimen) or ivermectin alone (0.2 mg/kg single or double doses) for human gnathostomiasis.
“Similar results were reported either using albendazole alone (the same regimen) or ivermectin alone (0.2 mg/kg single or double doses) [134–137]”
From Albendazole and Mebendazole as Anti-Parasitic and Anti-Cancer Agents: an Update (2021) · cites this paper as [136]
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Albendazole and Mebendazole as Anti-Parasitic and Anti-Cancer Agents: an Update
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A 41-Year-Old Woman with Migratory Panniculitis
Vanegas, E. S., Cendejas, R. F., & Mondragón, A. (2014) · The American Society of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.13-0318 · Cited by 7 · see citing works
- Authors
- KRAIVICHIAN, K., NUCHPRAYOON, S., SITICHALERNCHAI, P., CHAICUMPA, W., & YENTAKAM, S.
- Affiliations
- Thammasat University (TH)
- ORCID
- CHAICUMPA, WANPEN
- Venue
- The American Journal of Tropical Medicine and Hygiene
- Published
- 2004-11
- Volume
- 71
- Issue
- 5
- Pages
- 623-628
- ISSN
- 0002-9637 (ISSN-L)
- OpenAlex
- W1932345369
- Cited by
- 76
- References
- 0
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 3 · 2023: 6 · 2022: 2 · 2021: 5 · 2020: 2 · 2019: 1 · 2018: 2 · 2017: 4 · 2016: 2 · 2015: 5 · 2014: 6 · 2013: 4 · 2012: 3
- FWCI
- 2.45
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Tropical Medicine and Hygiene (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Parasitology › Parasites and Host Interactions
- Health Sciences › Medicine › Infectious Diseases › Parasitic Diseases Research and Treatment
- Life Sciences › Agricultural and Biological Sciences › Insect Science › Mollusks and Parasites Studies
- Keywords
- ivermectin, albendazole, anthelmintic treatment, treatment efficacy, relapse, Gnathostoma
- MeSH terms
- Administration, Oral, Adolescent, Adult, Animals, Anthelmintics, Antibodies, Helminth, Antiparasitic Agents, Drug Administration Schedule, Feces, Female, Gnathostoma, Humans, Ivermectin, Male, Middle Aged, Skin Diseases, Parasitic, Albendazole, Treatment Outcome, Spirurida Infections
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