HANTAVIRUS PULMONARY SYNDROME IN NORTHWESTERN ARGENTINA: CIRCULATION OF LAGUNA NEGRA VIRUS ASSOCIATED WITH CALOMYS CALLOSUS
Open accessAbstract
The purpose of this study was to characterize the hantaviruses circulating in northwestern Argentina. Human and rodent studies were conducted in Yuto, where most cases of hantavirus pulmonary syndrome (HPS) occur. Partial virus genome sequences were obtained from the blood of 12 cases of HPS, and from the lungs of 4 Calomys callosus and 1 Akodon simulator. Phylogenetic analysis showed that three genotypes associated with HPS circulate in Yuto. Laguna Negra (LN) virus, associated with C. laucha in Paraguay, was identified for the first time in Argentina; it was recovered from human cases and from C. callosus samples. The high sequence identity between human and rodent samples implicated C. callosus as the primary rodent reservoir for LN virus in Yuto. The genetic analysis showed that the Argentinian LN virus variant differed 16.8% at the nucleotide level and 2.9% at the protein level relative to the Paraguayan LN virus. The other two hantavirus lineages identified were the previously known Bermejo and Orán viruses.
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The hantavirus species in the Yuto study was not clearly identified, but it may be Laguna Negra, Bermejo, or Orán virus rather than ANDV.
“While the hantavirus species was not clearly identified in this study, it may be Laguna Negra, Bermejo, or Orán virus rather than ANDV [42].”
From Evidence for Human-to-Human Transmission of Hantavirus: A Systematic Review (2022) · cites this paper as [42]
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Alonso, D. O., Iglesias, A., Coelho, R., Periolo, N., Bruno, A., Córdoba, M. T., Filomarino, N., Quipildor, M., Biondo, E., Fortunato, E., et al. (2019) · Journal of Medical Virology · doi:10.1002/jmv.25446 · Cited by 70 · see citing works
Evidence for Human-to-Human Transmission of Hantavirus: A Systematic Review
Toledo, J., Haby, M. M., Reveiz, L., Sosa Leon, L., Angerami, R., & Aldighieri, S. (2022) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiab461 · Cited by 78 · see citing works
“In conclusion, this systematic review has shown that the evidence for human-to-human transmission of hantavirus is weak, specific to ANDV, and limited to some parts of Argentina and Chile.”
BackgroundInfluentialViral load of patients with hantavirus pulmonary syndrome in Argentina
Bellomo, C. M., Pires‐Marczeski, F. C., & Padula, P. J. (2015) · Journal of Medical Virology · doi:10.1002/jmv.24260 · Cited by 19 · see citing works
- Authors
- LEVIS, S., GARCIA, J., PINI, N., CALDERÓN, G., RAMÍREZ, J., BRAVO, D., JEOR, S. S., RIPOLL, C., BEGO, M., LOZANO, E., BARQUEZ, R., KSIAZEK, T. G., & ENRIA, D.
- Affiliations
- Centers for Disease Control and Prevention (US)
- Instituto Nacional de Enfermedades Virales Humanas Dr. Julio I. Maiztegui, Pergamino, Argentina; Hospital San Miguel, Yuto, Jujuy, Argentina; Hospital Oscar Orías, Libertador Gral. San Martín, Jujuy, Argentina; Department of Microbiology, University of Nevada, Reno, Nevada; Dirección de Epidemiología, Jujuy, Argentina; Fundación Miguel Lillo, Tucuman, Argentina; Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, Georgia
- Venue
- The American Journal of Tropical Medicine and Hygiene
- Published
- 2004-11
- Volume
- 71
- Issue
- 5
- Pages
- 658-663
- ISSN
- 0002-9637 (ISSN-L)
- OpenAlex
- W2150668580
- Cited by
- 64
- References
- 0
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 2 · 2023: 3 · 2022: 1 · 2021: 4 · 2020: 4 · 2019: 3 · 2018: 1 · 2017: 1 · 2016: 5 · 2015: 5 · 2014: 7 · 2013: 1 · 2012: 5
- FWCI
- 1.06
- Type
- journal article
- Language
- en
- Open access
- green
- sgc.anlis.gob.ar
- Licence
- other-oa
- Locations
- American Journal of Tropical Medicine and Hygiene (publishedVersion)
- PubMed (publishedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, other-oa)
- Funders
- National Institute of Allergy and Infectious Diseases (1R01 AI 45059, R01AI045059)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Viral Infections and Vectors
- Health Sciences › Medicine › Epidemiology › Virology and Viral Diseases
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Zoonotic diseases and public health
- Keywords
- hantavirus pulmonary syndrome, Calomys callosus, rodent reservoirs, hantavirus phylogeny, northwest Argentina
- MeSH terms
- Animals, Argentina, Genotype, Orthohantavirus, Humans, Phylogeny, RNA, Viral, Rodentia, Hantavirus Pulmonary Syndrome, Reverse Transcriptase Polymerase Chain Reaction, Rats
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