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TREATMENT OF EOSINOPHILIC MENINGITIS WITH A COMBINATION OF PREDNISOLONE AND MEBENDAZOLE
Abstract
To study the efficacy of the combination of prednisolone and mebendazole for the treatment of eosinophilic meningitis, we conducted a pilot study among Thai patients with eosinophilic meningitis. Patients were given a two-week course of prednisolone, 60 mg/day, and mebendazole, 10 mg/kg/day. The primary observation parameter was the number of patients who still had headaches after the two-week course of treatment. Forty-one patients were enrolled in the study. Four (10%) patients still had headaches after the two-week course of treatment and the median length of time until complete disappearance of headaches was three days. Serious side effects were not detected. Treatment for two weeks with the combination regimen of prednisolone and mebendazole is safe and beneficial in relieving headaches in patients with eosinophilic meningitis.
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In 41 patients with A. cantonensis infection, mebendazole (10 mg/kg daily for 14 days) in combination with prednisolone resulted in complete disappearance of headache in 37 (90.2%) within 14 days.
“Chotmongkol et al. [129] used mebendazole (10 mg/kg daily for 14 days) in combination with prednisolone in 41 patients, and headache completely disappeared in 37 (90.2%) patients within 14 days of treatment.”
From Albendazole and Mebendazole as Anti-Parasitic and Anti-Cancer Agents: an Update (2021) · cites this paper as [129]
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- 1975, 24, 921
- 2000, 31, 660
- 1965, 51, 392
- 1986, 72, 512
- 1988, 39, 191
- 1982, 31, 1114
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Albendazole and Mebendazole as Anti-Parasitic and Anti-Cancer Agents: an Update
Chai, J.-Y., Jung, B.-K., & Hong, S.-J. (2021) · The Korean Journal of Parasitology · doi:10.3347/kjp.2021.59.3.189 · Cited by 286
Metadata
- Authors
- CHOTMONGKOL, V., SAWADPANITCH, K., SAWANYAWISUTH, K., LOUHAWILAI, S., & LIMPAWATTANA, P.
- Affiliations
- Khon Kaen University (TH)
- Department of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
- Corresponding author
- CHOTMONGKOL, VERAJIT
- Venue
- The American Journal of Tropical Medicine and Hygiene
- Published
- 2006-06
- Volume
- 74
- Issue
- 6
- Pages
- 1122-1124
- ISSN
- 0002-9637 (ISSN-L)
- OpenAlex
- W2110310177
- Cited by
- 69
- References
- 0
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 1 · 2022: 2 · 2021: 3 · 2020: 8 · 2019: 1 · 2018: 3 · 2017: 1 · 2016: 4 · 2015: 1 · 2014: 7 · 2013: 6 · 2012: 2
- FWCI
- 3.08
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Tropical Medicine and Hygiene (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Parasitic Diseases Research and Treatment
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Mollusks and Parasites Studies
- Life Sciences › Immunology and Microbiology › Parasitology › Parasites and Host Interactions
- Keywords
- eosinophilic meningitis, prednisolone, mebendazole, combination therapy, headache relief, corticosteroids, antiparasitic treatment, treatment efficacy, drug safety
- MeSH terms
- Acetaminophen, Adolescent, Adult, Aged, Animals, Anti-Inflammatory Agents, Antinematodal Agents, Eosinophilia, Female, Humans, Male, Mebendazole, Meningitis, Middle Aged, Pilot Projects, Prednisolone, Treatment Outcome, Angiostrongylus cantonensis, Strongylida Infections, Analgesics, Non-Narcotic
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