SOUTHEAST ASIAN OVALOCYTOSIS AND PREGNANCY IN A MALARIA-ENDEMIC REGION OF PAPUA NEW GUINEA
Abstract
The band 3 deletion for southeast Asian ovalocytosis (SAO) occurs commonly in southeast Asia and the western Pacific. Southeast Asian ovalocytosis is associated with protection against cerebral malaria in children and therefore could reduce sequestration of erythrocytes parasitized by Plasmodium falciparum in the brain microvasculature. Sequestration of parasitized erythrocytes in the placenta accounts for much of the pathology of malaria during pregnancy. Therefore, we investigated the effect of SAO on malaria during pregnancy in the malaria-hyperendemic north coastal region of Papua New Guinea. The frequency of SAO in 927 women attending hospital for delivery was 8.7% (95% confidence interval = 6.9-10.5). Markers of fertility, the frequency of miscarriages and stillbirths, maternal anemia, placental and peripheral malaria at delivery, and birth weight were similar in women with and without SAO. In summary, although we can not exclude an interaction between SAO and malaria during pregnancy, we found no evidence that it provided a clinical benefit in this population.
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Severe anaemia is less common in unstable transmission settings.
“Nevertheless, severe anaemia is less common in these settings.39,41”
From Malaria in pregnancy. (2013) · cites this paper as [41]
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Malaria in pregnancy in the Asia-Pacific region
Rijken, M. J., McGready, R., Boel, M. E., Poespoprodjo, R., Singh, N., Syafruddin, D., Rogerson, S., & Nosten, F. (2012) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(11)70315-2 · Cited by 181 · see citing works
Takem, E. N., & D'Alessandro, U. (2013) · Mediterranean Journal of Hematology and Infectious Diseases · doi:10.4084/mjhid.2013.010 · Cited by 185 · see citing works
Stanisic, D. I., Moore, K. A., Baiwog, F., Ura, A., Clapham, C., King, C. L., Siba, P. M., Beeson, J. G., Mueller, I., Fowkes, F. J., et al. (2015) · Transactions of The Royal Society of Tropical Medicine and Hygiene · doi:10.1093/trstmh/trv019 · Cited by 52 · see citing works
- Authors
- O’DONNELL, A., RAIKO, A., CLEGG, J. B., WEATHERALL, D. J., & ALLEN, S. J.
- Affiliations
- John Radcliffe Hospital (GB)
- Corresponding author
- O’DONNELL, ANGELA
- ORCID
- ALLEN, STEPHEN J.
- Venue
- The American Journal of Tropical Medicine and Hygiene
- Published
- 2007-04
- Volume
- 76
- Issue
- 4
- Pages
- 631-633
- ISSN
- 0002-9637 (ISSN-L)
- OpenAlex
- W1932206666
- Cited by
- 8
- References
- 0
- Citations by year
- 2023: 1 · 2015: 2 · 2013: 1
- FWCI
- 1.03
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Tropical Medicine and Hygiene (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Wellcome Trust (035893)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Malaria Research and Control
- Health Sciences › Medicine › Genetics › Hemoglobinopathies and Related Disorders
- Health Sciences › Medicine › Physiology › Erythrocyte Function and Pathophysiology
- Keywords
- Southeast Asian ovalocytosis, malaria in pregnancy, Plasmodium falciparum, placental malaria, cerebral malaria, malaria prevention, anemia in pregnancy, miscarriage, stillbirth, birth weight, Papua New Guinea
- MeSH terms
- Adolescent, Adult, Asia, Southeastern, Elliptocytosis, Hereditary, Female, Humans, Papua New Guinea, Pregnancy, Pregnancy Complications, Parasitic, Malaria, Falciparum, Parasitemia
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