Malaria in Pregnancy Before and After the Implementation of a National IPTp Program in Gabon
Abstract
Intermittent preventive treatment in pregnancy (IPTp) with sulfadoxine–pyrimethamine has recently been adopted by many African countries to reduce maternal and neonatal morbidity and mortality associated with malaria in pregnancy. We assessed the impact of a newly established national IPTp program on maternal and neonatal health in Gabon. Data on prevalence of maternal Plasmodium falciparum infection, anemia, premature birth, and birth weight were collected in cross-sectional surveys in urban and rural regions of Gabon before and after the implementation of IPTp in a total of 1403 women and their offspring. After introduction of IPTp, the prevalence of maternal Plasmodium falciparum infection decreased dramatically (risk ratio 0.16, P < 0.001). Whereas only a modest effect on the rate of anemia in pregnant women was observed, there was a marked benefit on the prevalence of low birth weight and premature birth for women adhering to national recommendations. These effects were most pronounced in primi- and secundigravid women.
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IPTp-SP can reduce the prevalence of maternal P.falciparum infection, low birth weight and preterm birth, particularly in women in their first and second pregnancies.
“Studies have demonstrated that IPTp-SP can reduce the prevalence of maternal P.falciparum infection, low birth weight and preterm birth, particularly in women in their first and second pregnancies [21, 145–147]”
From Current update on malaria in pregnancy: a systematic review (2025) · cites this paper as [145]
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References 14 · Cited by 56
- Authors
- Ramharter, M., Schuster, K., Bouyou-Akotet, M. K., Adegnika, A. A., Schmits, K., Mombo-Ngoma, G., Agnandji, S. T., Nemeth, J., Afène, S. N., Issifou, S., Onnas, I. N., Kombila, M., & Kremsner, P. G.
- Affiliations
- Albert Schweitzer Hospital (GA)
- Medical Research Unit, Albert Schweitzer Hospital, Lambaréné, Gabon; Institut Pasteur, Université de la Méditerranée, Marseille, France; Department of Medicine I, Division of Infectious Diseases and Tropical Medicine, Medical University of Vienna, Vienna, Austria; Institute for Tropical Medicine, Department for Parasitology, University of Tübingen, Tübingen, Germany; Département de Parasitologie, Mycologie, Médecine Tropicale, Université des Sciences de la Santé, Libreville...
- Corresponding author
- Ramharter, Michael
- Venue
- The American Journal of Tropical Medicine and Hygiene
- Published
- 2007-09
- Volume
- 77
- Issue
- 3
- Pages
- 418-422
- ISSN
- 0002-9637 (ISSN-L)
- OpenAlex
- W2148673502
- Cited by
- 56
- References
- 14
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 1 · 2023: 2 · 2022: 3 · 2021: 2 · 2018: 5 · 2017: 1 · 2016: 2 · 2015: 1 · 2014: 6 · 2013: 7 · 2012: 3
- FWCI
- 5.15
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Tropical Medicine and Hygiene (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Malaria Research and Control
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Global Maternal and Child Health
- Health Sciences › Medicine › Infectious Diseases › HIV/AIDS Research and Interventions
- Keywords
- intermittent preventive treatment in pregnancy, sulfadoxine-pyrimethamine, malaria in pregnancy, Plasmodium falciparum, anemia in pregnancy, low birth weight, preterm birth, program impact, primigravida, Gabon
- MeSH terms
- Adolescent, Adult, Antimalarials, Cross-Sectional Studies, Female, Gabon, Humans, Parity, Pregnancy, Time Factors, Pregnancy Complications, Parasitic, Malaria, Falciparum
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