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Cited by 264

The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.

Pyrethroid Resistance in Aedes aegypti from Grand Cayman

Open access
Harris, Angela F., Rajatileka, Shavanthi, Ranson, Hilary·2010·The American Society of Tropical Medicine and Hygiene

Abstract

The Grand Cayman population of Aedes aegypti is highly resistant to DDT and pyrethroid insecticides. Glutathione transferase, cytochrome P450, and esterase levels were increased in the Grand Cayman population relative to a susceptible laboratory strain, but synergist studies did not implicate elevated insecticide detoxification as a major cause of resistance. The role of target site resistance was therefore investigated. Two substitutions in the voltage-gated sodium channel were identified, V1016I in domain II, segment 6 (IIS6) (allele frequency = 0.79) and F1534C in IIIS6 (allele frequency = 0.68). The role of the F1534C mutation in conferring resistance to insecticides has not been previously established and so a tetraplex polymerase chain reaction assay was designed and used to genotype mosquitoes that had been exposed to insecticides. The F1534C mutation was strongly correlated with resistance to DDT and permethrin.

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Metadata

Authors
Harris, A. F., Rajatileka, S., & Ranson, H.
Venue
The American Society of Tropical Medicine and Hygiene
Published
2010-08-05
Volume
83
Issue
2
Pages
277-284
ISSN
  • 0002-9637 (ISSN-L)
  • 1476-1645
OpenAlex
W2125067724
Cited by
264
References
28
FWCI
4.25
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Pyrethroid Resistance in Aedes aegypti from Grand Cayman. https://app.cochat.ai/papers/10.4269/ajtmh.2010.09-0623
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Harris, A. F., Rajatileka, S., & Ranson, H. (2010). Pyrethroid Resistance in Aedes aegypti from Grand Cayman. The American Society of Tropical Medicine and Hygiene. https://doi.org/10.4269/ajtmh.2010.09-0623

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