Influence of the Timing of Malaria Infection during Pregnancy on Birth Weight and on Maternal Anemia in Benin
Open accessAbstract
Although consequences of malaria in pregnancy are well known, the period of pregnancy in which infection has the highest impact is still unclear. In Benin, we followed up a cohort of 1,037 women through pregnancy until delivery. The objective was to evaluate the relationship between the timing of infection and birth weight, and maternal anemia at delivery. At the beginning of pregnancy, peripheral infections were associated with a decrease in mean birth weight (−98.5 g; P = 0.03) and an increase in the risk of anemia at delivery (adjusted odds ratio [aOR] = 1.6; P = 0.03). Infections in late pregnancy were related to a higher risk of maternal anemia at delivery (aOR = 1.7; P = 0.001). To fully protect the women during the whole pregnancy, already implemented measures (insecticide-treated nets and intermittent preventive treatment) should be reinforced. In the future, a vaccine against pregnancy-associated malaria parasites could protect the women in early pregnancy, which seems to be a high-risk period.
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In stable transmission settings, most malaria infections in pregnancy are asymptomatic but increase substantially the risk of anaemia.
“Where transmission is stable, such as in most of sub-Saharan Africa, most infections are asymptomatic but increase substantially the risk of anaemia.19,26,30–31”
From Malaria in pregnancy. (2013) · cites this paper as [30]
Malaria infections in the first or second trimester of pregnancy increase the risk of anaemia.
“Malaria infections in the first or second trimester of pregnancy increase the risk of anaemia,24,30 though one study reported an increased risk also for infections occurring in the third trimester.30”
From Malaria in pregnancy. (2013) · cites this paper as [30]
Malaria increases the risk of low birth weight, particularly in primigravidae, and this risk seems higher for infections in the first or second trimester.
“Malaria increases the risk of low birth weight (LBW),19,23,30,49–51 particularly in primigravidae, and this risk seems to be higher for infections in first or second trimester,23–24,30,49 though in one study this was true also for infections occurring late in pregnancy.49”
From Malaria in pregnancy. (2013) · cites this paper as [30]
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References 32 · Cited by 124
- Authors
- Huynh, B.-T., Fievet, N., Gbaguidi, G., Dechavanne, S., Borgella, S., Guézo-Mévo, B., Massougbodji, A., Ndam, N. T., Deloron, P., & Cot, M.
- Affiliations
- Santé Internationale de la mère et de l'enfant (FR)
- Corresponding author
- Huynh, Bich-Tram
- ORCID
- Venue
- The American Society of Tropical Medicine and Hygiene
- Published
- 2011-08-01
- Volume
- 85
- Issue
- 2
- Pages
- 214-220
- ISSN
- 0002-9637 (ISSN-L)
- 1476-1645
- PMC
- PMC3144815
- OpenAlex
- W2123654797
- Cited by
- 124
- References
- 32
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 4 · 2023: 4 · 2022: 6 · 2021: 9 · 2020: 10 · 2019: 7 · 2018: 11 · 2017: 9 · 2016: 12 · 2015: 7 · 2014: 11 · 2013: 18 · 2012: 10
- FWCI
- 12.58
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- American Journal of Tropical Medicine and Hygiene (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Malaria Research and Control
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Global Maternal and Child Health
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Keywords
- malaria in pregnancy, timing of infection, birth weight, anemia in pregnancy, peripheral infection, early pregnancy, late pregnancy, intermittent preventive treatment, insecticide-treated nets, Benin
- MeSH terms
- Adolescent, Adult, Anemia, Benin, Female, Humans, Middle Aged, Pregnancy, Pregnancy Trimesters, Pregnancy Complications, Parasitic, Malaria, Falciparum, Young Adult
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