Histopathological and immunohistochemical changes of the marginal periodontium in patients with Turner syndrome
Open accessAbstract
Turner syndrome (TS) is characterized by partial or complete loss of a sexual chromosome, resulting in an incomplete development of the body, gonadic failure, cardiac and renal abnormalities, oro-dental changes, etc. In our study, we proposed to perform a histological and immunohistochemical (IHC) study of the periodontium changes in patients with TS. The biological material under study was represented by fragments of gingival mucosa harvested from 18 patients with TS who presented advanced periodontal lesions and required dental extractions. The fragments of gingival mucosa were processed by the classical histological technique of paraffin inclusion, subsequently the obtained sections being stained by the Hematoxylin-Eosin (HE) and examined under the optical microscope. For the IHC study, there were performed serial sections incubated with anti-cluster of differentiation (CD) 3, anti-CD20 and anti-CD68 antibodies for highlighting immune cells, as well as with anti-matrix metalloproteinase (MMP) 2 and anti-MMP8 antibodies for highlighting MMPs (MMP2 and MMP8) involved in the periodontal tissue lesions. In the present study, during the histological examination, there were observed morphological changes, both in the epithelium and in the gingival mucosa chorion. Epithelial changes consisted in the onset of acanthosis processes, in the thickening of the epithelium due to the increase of the spinous layer, as well as in the parakeratosis phenomenon. In the chorion, there was observed the presence of inflammatory infiltrates in various stages, presence of fibrosis (extended in some cases) and the presence of an important vascularization in some cases, with a high number of immunocompetent cells involved in the inborn immune response, but also in the adaptive one, as well as a more or less intense immunoexpression of MMP2 and MMP8. Our study suggests that TS may contribute to the development of some inflammatory processes in the marginal periodontium.
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Dental and periodontal problems in TS include reduced tooth crown height (predominant finding), alteration in tooth morphology and root size, bifurcated and supernumerary roots, increased root resorption, increased tooth mobility, early tooth loss, smaller primary and permanent teeth, thin hypoplastic enamel, abnormal dentin, variation in eruption patterns and periodontal disease.
“Dental and periodontal problems in TS include reduced tooth crown height (predominant finding), alteration in tooth morphology and root size, bifurcated and supernumerary roots, increased root resorption, increased tooth mobility, early tooth loss, smaller primary and permanent teeth, thin hypoplastic enamel, abnormal dentin, variation in eruption patterns and periodontal disease.663-665”
From Clinical practice guidelines for the care of girls and women with Turner syndrome. (2024) · cites this paper as [664]
While caries may be less prevalent, periodontal disease such as gingivitis appears to be more common in TS.
“While caries may be less prevalent, periodontal disease such as gingivitis appears to be more common.664”
From Clinical practice guidelines for the care of girls and women with Turner syndrome. (2024) · cites this paper as [664]
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References 56 · Cited by 3
Research works printed but not linked: 5
- [9]Jones KL Recognizable patterns of malformation Jones KL Jones MC Del Campo M Smith’s recognizable patterns of human malformation 7 2013 Philadelphia PA USA Elsevier-Saunders 318 319 https://www.us.elsevierhealth.com/smiths-recognizable-patterns-of-human-malformation-9781455738113.html
- [18]Borkowska M Gawlik A Hankus M Małecka-Tendera E Zaburzenia stomatologiczno-ortodontyczne u pacjentek z zespołem Turnera [Dental abnormalities and orthodontic disorders in Turner’s syndrome patients] Pediatr Endocrinol Diabetes Metab 2015 21 3 143 148 https://www.termedia.pl/-Zaburzenia-stomatologiczno-ortodontyczne-u-pacjentek-z-zespolem-Turnera-,138,36577,0,1.html 27275770
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- Authors
- PhD Student, F. O. D. M., Preda, S. A., Predescu, A. M., Department of Histology and Cytology, F. O. D. M., Stoica, L. E., Department of Dermatology, F. O. M., Albulescu, D. M., Department of Anatomy, F. O. M., Ionovici, N., Department of Occupational Medicine, F. O. M., Bugălă, N. M., PhD Student, F. O. M., Popescu, M., Department of Endocrinology, U. O. M. A. P. O. C., Ţuculină, M. J., & Department of Odontology, F. O. D. M.
- Affiliations
- University of Medicine and Pharmacy of Craiova (RO)
- Venue
- Romanian Journal of Morphology and Embryology
- Publisher
- Societatea Romana de Morfologie
- Published
- 2021-10-10
- Volume
- 62
- Issue
- 1
- Pages
- 239-247
- ISSN
- 1220-0522 (ISSN-L)
- 2066-8279
- PMC
- PMC8597370
- OpenAlex
- W3204506249
- Cited by
- 3
- References
- 56
- Citations by year
- 2024: 1 · 2023: 1 · 2022: 1
- FWCI
- 0.78
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Locations
- Romanian Journal of Morphology and Embryology (publishedVersion)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Health Sciences › Health Professions › Pharmacy › Oral and gingival health research
- Health Sciences › Dentistry › Periodontics › Oral Health Pathology and Treatment
- Keywords
- Turner syndrome, marginal periodontium, gingival mucosa, periodontal lesions, matrix metalloproteinases, MMP-2, MMP-8, epidermal hyperplasia, parakeratosis, inflammatory cell infiltration, immune cells, CD3, CD20, CD68, vascularization
- MeSH terms
- Epithelium, Gingiva, Humans, Periodontal Ligament, Periodontium, Turner Syndrome, Matrix Metalloproteinase 2
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