Physical activity, exercise, and mental disorders: it is time to move on
Open accessAbstract
INTRODUCTION: Physical activity, conceptualized as any bodily movement that results in energy expenditure, and its structured form, exercise, play an important role in public health, preventing and treating a wide range of physical conditions, including metabolic and cardiovascular diseases and obesity. OBJECTIVE: This article aims to provide a brief overview and summary of the evidence on: 1) the preventive effects of physical activity on a wide range of mental disorders; 2) the role of physical activity in promoting the physical health of people with mental disorders; 3) the role of exercise as a strategy to manage mental health symptoms in a range of mental disorders; and 4) the challenges and barriers faced when implementing exercise in clinical practice. METHODS: This was a narrative review. RESULTS: Compelling evidence has demonstrated that physical activity and exercise can also prevent common mental disorders, such as depression and anxiety disorders, and have multiple beneficial effects on the physical and mental health of people with a wide range of mental disorders. This body of evidence has been incorporated in national and international guidelines over the last decades, which have recommended the inclusion of physical activity and exercise as therapeutic approaches for mental disorders, mainly for depression and schizophrenia. Nonetheless, implementation into clinical practice has been slow, probably due to barriers associated both with patients and mental health professionals. CONCLUSION: Increases in physical activity levels in populations are likely to reduce the mental health burden. Exercise interventions should be incorporated to the routine care of people with mental disorders due its multiple benefits on physical and mental health outcomes. A multidisciplinary approach is needed to overcome patients barriers and enhance adherence and benefits.
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Postnatal women may particularly benefit from exercise.
“That postnatal women may particularly benefit from exercise is especially significant given the high prevalence and potential severity of postpartum depression 143”
From Effect of exercise on depression and anxiety symptoms: systematic umbrella review with meta-meta-analysis (2026) · cites this paper as [145]
The section on the effects of exercise on mental health symptoms (page unavailable) reports reduced depressive symptoms in people with depression. It does not address postnatal women or establish that they particularly benefit; searches for postnatal, postpartum, and perinatal terms found no such passage. (LLM, conf=0.78)
Experimental — accuracy not yet measuredExercise is a low-risk, high-benefit strategy for improving maternal mental health during the postnatal period.
“underscoring the potential of exercise as a low-risk, high-benefit strategy for improving maternal mental health during this vulnerable period 144 145 .”
From Effect of exercise on depression and anxiety symptoms: systematic umbrella review with meta-meta-analysis (2026) · cites this paper as [145]
The section on mental health symptoms reports that exercise reduces depressive symptoms in people with depression. It does not establish that exercise improves maternal mental health specifically during the postnatal period or that it is low-risk in that setting. (LLM, conf=0.86)
Experimental — accuracy not yet measured
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References 80 · Cited by 251
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- [6]6. Schuch F, Vancampfort D, Firth J, Rosenbaum S, Ward P, Reichert T, et al. Physical activity and sedentary behavior in people with major depressive disorder: a systematic review and meta-analysis. J Affec Disord. 2017;210:139-50. 28033521
- [7]7. Stubbs B, Firth J, Berry A, Schuch FB, Rosenbaum S, Gaughran F, et al. How much physical activity do people with schizophrenia engage in? A systematic review, comparative meta-analysis and meta-regression. Schizophrenia Res. 2016;176:431-40. 27261419
- [8]8. Vancampfort D, Firth J, Schuch F, Rosenbaum S, De Hert M, Mugisha J, et al. Physical activity and sedentary behavior in people with bipolar disorder: a systematic review and meta-analysis. J Affect Disord. 2016;201:145-52. 27235817
- [10]10. Jorm AF, Patten SB, Brugha TS, Mojtabai R. Has increased provision of treatment reduced the prevalence of common mental disorders? Review of the evidence from four countries. World Psychiatry. 2017;16:90-9. PMC5269479 28127925
- [14]14. Machado MO, Veronese N, Sanches M, Stubbs B, Koyanagi A, Thompson T, et al. The association of depression and all-cause and cause-specific mortality: an umbrella review of systematic reviews and meta-analyses. BMC Med. 2018;16:112. PMC6053830 30025524
- [16]16. Vancampfort D, Stubbs B, Mitchell AJ, De Hert M, Wampers M, Ward PB, et al. Risk of metabolic syndrome and its components in people with schizophrenia and related psychotic disorders, bipolar disorder and major depressive disorder: a systematic review and meta-analysis. World Psychiatry. 2015;14:339-47. PMC4592657 26407790
- [17]17. Ostrow L, Jessell L, Hurd M, Darrow SM, Cohen D. Discontinuing psychiatric medications: a survey of long-term users. Psychiatr Serv. 2017;68:1232-38. 28712356
- [18]18. Ashoorian D, Davidson R, Rock D, Dragovic M, Clifford R. A clinical communication tool for the assessment of psychotropic medication side effects. Psychiatry Res. 2015;230:643-57. 26518225
- [19]19. Wykes T, Evans J, Paton C, Barnes T, Taylor D, Bentall R, et al. What side effects are problematic for patients prescribed antipsychotic medication? The Maudsley Side Effects (MSE) measure for antipsychotic medication. Psychol Med. 2017;47:2369-78. PMC5820531 28420450
- [20]20. Batman DC. Hippocrates: ‘Walking is man’s best medicine!’ Occup Med (Lond). 2012;62:320-22. 22764266
- [21]21. Caspersen CJ, Powell KE, Christenson GM. Physical activity, exercise, and physical fitness: definitions and distinctions for health-related research. Public Health Rep. 1985;100:126-31. PMC1424733 3920711
- [22]22. Pearce PZ. Exercise is medicine. Curr Sports Med Rep. 2008;7:171-5. 18477876
- [25]25. Bortolato B, Köhler CA, Evangelou E, León-Caballero J, Solmi M, Stubbs B, et al. Systematic assessment of environmental risk factors for bipolar disorder: an umbrella review of systematic reviews and meta-analyses. Bipolar Disord. 2017;19:84-96. 28470927
- [29]29. Byrne EM, Yang J, Wray NR. Inference in psychiatry via 2-sample mendelian randomization-from association to causal pathway? JAMA Psychiatry. 2017;74:1191-92. 29094155
- [32]32. Schuch FB, Stubbs B, Meyer J, Heissel A, Zech P, Vancampfort D, et al. Physical activity protects from incident anxiety: A meta-analysis of prospective cohort studies. Depress Anxiety. 2019;36:846-58. 31209958
- [33]33. Strohle A, Hofler M, Pfister H, Muller AG, Hoyer J, Wittchen HU, et al. Physical activity and prevalence and incidence of mental disorders in adolescents and young adults. Psychol Med. 2007;37:1657-66. 17579930
- [37]37. Lee IM, Shiroma EJ, Lobelo F, Puska P, Blair SN, Katzmarzyk PT, et al. Effect of physical inactivity on major non-communicable diseases worldwide: an analysis of burden of disease and life expectancy. Lancet. 2012;380:219-29. PMC3645500 22818936
- [38]38. Kahl KG, Kerling A, Tegtbur U, Gutzlaff E, Herrmann J, Borchert L, et al. Effects of additional exercise training on epicardial, intra-abdominal and subcutaneous adipose tissue in major depressive disorder: a randomized pilot study. J Affect Disord. 2016;192:91-7. 26707353
- [39]39. Krogh J, Videbech P, Thomsen C, Gluud C, Nordentoft M. DEMO-II Trial. Aerobic exercise versus stretching exercise in patients with major depression—a randomised clinical trial. PloS One. 2012;7:e48316. PMC3485141 23118981
- [40]40. Vancampfort D, Firth J, Correll CU, Solmi M, Siskind D, De Hert M, et al. The impact of pharmacological and non-pharmacological interventions to improve physical health outcomes in people with schizophrenia: a meta-review of meta-analyses of randomized controlled trials. World Psychiatry. 2019;18:53-66. PMC6313230 30600626
- [41]41. Orozco-Beltran D, Gil-Guillen VF, Redon J, Martin-Moreno JM, Pallares-Carratala V, Navarro-Perez J, et al. Lipid profile, cardiovascular disease and mortality in a Mediterranean high-risk population: the ESCARVAL-RISK study. PloS One. 2017;12:e0186196. PMC5646809 29045483
- [46]46. Carneiro LF, Mota MP, Schuch F, Deslandes A, Vasconcelos-Raposo J. Portuguese and Brazilian guidelines for the treatment of depression: exercise as medicine. Braz J Psychiatry. 2018;40:210-11. PMC6900767 28876380
- [48]48. Hallgren M, Stubbs B, Vancampfort D, Lundin A, Jaakallio P, Forsell Y. Treatment guidelines for depression: Greater emphasis on physical activity is needed. Eur Psychiatry. 2017;40:1-3. 27837666
- [49]49. Malhi GS, Outhred T, Hamilton A, Boyce PM, Bryant R, Fitzgerald PB, et al. Royal Australian and New Zealand College of Psychiatrists clinical practice guidelines for mood disorders: major depression summary. Med J Aust. 2018;208:175-80. 29490210
- [50]50. Fleck MP, Berlim MT, Lafer B, Sougey EB, Del Porto JA, Brasil MA, et al. [Review of the guidelines of the Brazilian Medical Association for the treatment of depression (Complete version)]. Braz J Psychiatry. 2009;31 Suppl 1:S7-S17. 19565151
- [53]53. Gordon BR, McDowell CP, Hallgren M, Meyer JD, Lyons M, Herring MP. Association of efficacy of resistance exercise training with depressive symptoms: meta-analysis and meta-regression analysis of randomized clinical trials. JAMA Psychiatry. 2018;75:566-76. PMC6137526 29800984
- [54]54. Brondino N, Rocchetti M, Fusar-Poli L, Codrons E, Correale L, Vandoni M, et al. A systematic review of cognitive effects of exercise in depression. Acta Psychiatr Scand. 2017;135:285-95. 28110494
- [58]58. Firth J, Stubbs B, Rosenbaum S, Vancampfort D, Malchow B, Schuch F, et al. Aerobic exercise improves cognitive functioning in people with schizophrenia: a systematic review and meta-analysis. Schizophr Bull. 2017;43:546-56. PMC5464163 27521348
- [60]60. Wright K, Armstrong T, Taylor A, Dean S. ‘It’s a double edged sword’: a qualitative analysis of the experiences of exercise amongst people with bipolar disorder. J Affect Disord. 2012;136:634-42. 22100131
- [62]62. Kleemann E, Bracht CG, Stanton R, Schuch FB. Exercise prescription for people with mental illness: an evaluation of mental health professionals’ knowledge, beliefs, barriers, and behaviors. Braz J Psychiatry. 2020;42:271-77. PMC7236166 32130402
- [64]64. Firth J, Siddiqi N, Koyanagi A, Siskind D, Rosenbaum S, Galletly C, et al. The Lancet Psychiatry Commission: a blueprint for protecting physical health in people with mental illness. Lancet Psychiatry. 2019;6:675-712. 31324560
- [65]65. Pelletier L, Shanmugasegaram S, Patten SB, Demers A. Self-management of mood and/or anxiety disorders through physical activity/exercise. Health Promot Chronic Dis Prev Can. 2017;37:149-59. 28493659
- [66]66. Firth J, Rosenbaum S, Stubbs B, Gorczynski P, Yung AR, Vancampfort D. Motivating factors and barriers towards exercise in severe mental illness: a systematic review and meta-analysis. Psychol Med. 2016;46:2869-81. PMC5080671 27502153
- [67]67. Vancampfort D, Madou T, Moens H, De Backer T, Vanhalst P, Helon C, et al. Could autonomous motivation hold the key to successfully implementing lifestyle changes in affective disorders? A multicentre cross sectional study. Psychiatry Res. 2015;228:100-6. 25956760
- [68]68. Vancampfort D, Stubbs B, Venigalla SK, Probst M. Adopting and maintaining physical activity behaviours in people with severe mental illness: the importance of autonomous motivation. Prev Med. 2015;81:216-20. 26386141
- [69]69. Vancampfort D, De Hert M, Vansteenkiste M, De Herdt A, Scheewe TW, Soundy A, et al. The importance of self-determined motivation towards physical activity in patients with schizophrenia. Psychiatry Res. 2013;210:812-8. 24182688
- [72]72. Brand R, Ekkekakis P. Affective-reflective theory of physical inactivity and exercise. Ger J Exerc Sport Res. 2018;48:48-58.
- [73]73. Schuch FB, Dunn AL, Kanitz AC, Delevatti RS, Fleck MP. Moderators of response in exercise treatment for depression: a systematic review. J Affect Disord. 2016;195:40-9. 26854964
- [74]74. Stubbs B, Vancampfort D, Rosenbaum S, Ward PB, Richards J, Soundy A, et al. Dropout from exercise randomized controlled trials among people with depression: a meta-analysis and meta regression. J Affect Disord. 2016;190:457-66. 26551405
- [75]75. Vancampfort D, Rosenbaum S, Schuch FB, Ward PB, Probst M, Stubbs B. Prevalence and predictors of treatment dropout from physical activity interventions in schizophrenia: a meta-analysis. Gen Hosp Psychiatry 2016;39:15-23. 26719106
- [76]76. Vancampfort D, Sánchez CP, Hallgren M, Schuch F, Firth J, Rosenbaum S, et al. Dropout from exercise randomized controlled trials among people with anxiety and stress-related disorders: a meta-analysis and meta-regression. J Affect Disord. 2021;282:996-1004. 33601745
- Authors
- Schuch, F. B., & Vancampfort, D.
- Affiliations
- Universidade Federal de Santa Maria (BR)
- KU Leuven (BE)
- Corresponding author
- Schuch, Felipe Barreto
- Venue
- Trends in Psychiatry and Psychotherapy
- Publisher
- EDITORA SCIENTIFIC
- Published
- 2021
- Volume
- 43
- Issue
- 3
- Pages
- 177-184
- ISSN
- 2237-6089 (ISSN-L)
- 2238-0019
- PMC
- PMC8638711
- OpenAlex
- W3154472286
- Cited by
- 251
- References
- 80
- Citations by year
- 2026: 35 · 2025: 80 · 2024: 74 · 2023: 49 · 2022: 13
- FWCI
- 21.37
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by
- Locations
- Trends in Psychiatry and Psychotherapy (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, other-oa)
- Lirias (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Topics
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- physical activity, mental illness, depression, anxiety disorders, schizophrenia, exercise intervention, implementation barriers, clinical practice, adherence, multidisciplinary care
- MeSH terms
- Anxiety Disorders, Mental Disorders, Humans, Mental Health, Schizophrenia, Exercise
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