Malaria in the Intensive Care Unit
Open accessAbstract
Hegde A. Malaria in the Intensive Care Unit. Indian J Crit Care Med 2021;25(Suppl 2):S127-S129.
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Sequestration and rosette formation impair the spleen's ability to effectively clear infected erythrocytes, ultimately leading to organ dysfunction.
“This sequestration and the formation of “rosettes” (the adherence of infected erythrocytes to uninfected cells) impair the spleen's ability to effectively clear the infected erythrocytes, ultimately leading to organ dysfunction [92, 93].”
From Current update on malaria in pregnancy: a systematic review (2025) · cites this paper as [92]
The Pathophysiology of Severe Falciparum Malaria section says sequestration prevents efficient splenic clearance of infected RBCs, while sequestration and rosetting together block the microvasculature and contribute to organ dysfunction. It does not say that rosetting impairs splenic clearance or that impaired clearance is the route to organ dysfunction. (LLM, conf=0.88)
Experimental — accuracy not yet measuredThese knobs express PfEMP1, enabling infected cells to adhere to receptors on the capillary and venous endothelium, a process known as sequestration.
“These knobs express an adhesive protein called P.falciparum erythrocyte membrane protein 1 (PfEMP1), enabling the infected cells to adhere to receptors on the capillary and venous endothelium, a process known as sequestration.”
From Current update on malaria in pregnancy: a systematic review (2025) · cites this paper as [92]
The treatment of severe P.vivax malaria is similar to that of severe P.falciparum malaria.
“The treatment of severe P.vivax malaria is similar to that of severe P.falciparum malaria [92, 133].”
From Current update on malaria in pregnancy: a systematic review (2025) · cites this paper as [92]
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References 6 · Cited by 4
- Authors
- Hegde, A.
- Affiliations
- P. D. Hinduja Hospital and Medical Research Centre (IN)
- Corresponding author
- Ashit Hegde
- Venue
- Indian Journal of Critical Care Medicine
- Publisher
- Jaypee Brothers Medical Publishing
- Published
- 2021-05-01
- Volume
- 25
- Issue
- S2
- Pages
- S127-S129
- ISSN
- 0972-5229 (ISSN-L)
- 1998-359X
- PMC
- PMC8327785
- OpenAlex
- W3172392656
- Cited by
- 4
- References
- 6
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 1
- FWCI
- 0.43
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Locations
- Indian Journal of Critical Care Medicine (publishedVersion)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Malaria Research and Control
- Health Sciences › Medicine › Epidemiology › Sepsis Diagnosis and Treatment
- Health Sciences › Medicine › Genetics › Hemoglobinopathies and Related Disorders
- Keywords
- malaria, intensive care unit, critically ill patients
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