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Cited by 52Gastroesophageal reflux and treatmentsGastrointestinal motility and disordersEsophageal Cancer Research and Treatment

Esophageal motor dysfunctions in gastroesophageal reflux disease and therapeutic perspectives

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Lin, Sihui, Li, Hua, Fang, Xiucai·2019·Journal of Neurogastroenterology and Motility
DOI 10.5056/jnm19081PMC PMC6786454
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Abstract

Gastroesophageal reflux disease (GERD) is a very common disease, and the prevalence in the general population has recently increased. GERD is a chronic relapsing disease associated with motility disorders of the upper gastrointestinal tract. Several factors are implicated in GERD, including hypotensive lower esophageal sphincter, frequent transient lower esophageal sphincter relaxation, esophageal hypersensitivity, reduced resistance of the esophageal mucosa against the refluxed contents, ineffective esophageal motility, abnormal bolus transport, deficits initiating secondary peristalsis, abnormal response to multiple rapid swallowing, and hiatal hernia. One or more of these mechanisms result in the reflux of stomach contents into the esophagus, delayed clearance of the refluxate, and the development of symptoms and/or complications. New techniques, such as 24-hour pH and multichannel intraluminal impedance monitoring, multichannel intraluminal impedance and esophageal manometry, high-resolution manometry, 3-dimensional highresolution manometry, enoscopic functional luminal imaging probe, and 24-hour dynamic esophageal manometry, provide more information on esophageal motility and have clarified the pathophysiology of GERD. Proton pump inhibitors remain the preferred pharmaceutical option to treat GERD. The ideal target of GERD treatment is to restore esophageal motility and reconstruct the antireflux mechanism. This review focuses on current advances in esophageal motor dysfunction in patients with GERD and the influence of these developments on GERD treatment.

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  • Greater GERD duration causes increased erosive esophagitis, strictures, ulceration, and Barrett's esophagus.

    “Greater GERD duration causes increased erosive esophagitis, strictures, ulceration, and Barrett’s esophagus (Lin et al., 2019; Adanir et al., 2021).”

    From Thyroid disorders and gastrointestinal dysmotility: an old association (2024) · cites this paper as Lin et al., 2019

    The Introduction (page unavailable) says frequent and severe reflux may result in reflux esophagitis. The section on impaired esophageal clearance (page unavailable) also links prolonged acid exposure to esophagitis and related complications. Neither passage establishes that greater duration of GERD causes more complications, or specifically identifies strictures, ulceration, and Barrett’s esophagus as outcomes of longer GERD duration. (LLM, conf=0.86)

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Cited by

Sorted by citations

Authors
Lin, S., Li, H., & Fang, X.
Affiliations
  • Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
  • First Affiliated Hospital of Xiamen University (CN)
Corresponding author
Fang, Xiucai
ORCID
Venue
Journal of Neurogastroenterology and Motility
Publisher
The Korean Society of Neurogastroenterology and Motility
Published
2019-10-30
Volume
25
Issue
4
Pages
499-507
ISSN
  • 2093-0879 (ISSN-L)
  • 2093-0887
DOI
10.5056/jnm19081
PMC
PMC6786454
OpenAlex
W2977930428
Cited by
52
References
0
Citations by year
2026: 4 · 2025: 6 · 2024: 9 · 2023: 9 · 2022: 7 · 2021: 13 · 2020: 4
FWCI
1.09
Type
journal article
Language
en
Open access
Licence
cc-by-nc
Locations
  • Journal of Neurogastroenterology and Motility (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Gastroenterology › Gastroesophageal reflux and treatments
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
  • Health Sciences › Medicine › Surgery › Esophageal Cancer Research and Treatment
Keywords
gastroesophageal reflux disease, esophageal motility disorders, lower esophageal sphincter dysfunction, transient lower esophageal sphincter relaxations, esophageal hypersensitivity, esophageal peristalsis, hiatal hernia, antireflux surgery, proton pump inhibitors, high-resolution manometry, impedance-pH monitoring, esophageal clearance

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