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Efficacy of topical permethrin as repellent against 's bites
Open accessAbstract
Mosquitoes are the most important vectors of infectious diseases and their bites are related to several adverse skin reactions. Permethrin impregnated clothes are an efficient strategy against arthropods' bites; however, its topical efficacy as a repellent has not been well established. We studied the response to permethrin lotion 5 percent and N,N-Diethyl-meta-toluamide (DEET) spray 50 percent applied to the unprotected forearms of 10 volunteers. Each arm was exposed to 20 female mosquitoes of Aedes aegypti. We performed 71 bilateral comparative measurements evaluating the timing for the first bites. The average times for the arm without the product, with permethrin 5 percent, and with DEET 50 percent were: 7.9 seconds, 336.2 seconds and 7512.1 seconds. The results showed a significant difference between repellency times between either product and unprotected controls. In addition, there was a significant difference in time to first bite between permethrin and DEET treated arms (p<0.01). Permethrin affords some repellent activity against Aedes aegypti bites in this experimental setting. However, permethrin's profile of repellency was significantly inferior to that of DEET.
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In addition to their insecticidal effect, pyrethroids have both spatial repellent and contact irritant effects, though excitorepellency is probably the most important effect when pyrethroids are used on clothing.
“In addition to their insecticidal effect, pyrethroids have both spatial repellent and contact irritant effects,[17–19] though excitorepellency is probably the most important effect when pyrethroids are used on clothing.”
From Pyrethroid insecticides maintain repellent effect on knock-down resistant populations of Aedes aegypti mosquitoes (2018) · cites this paper as [19]
The Introduction identifies permethrin as a pyrethroid and describes its insecticidal effect on clothing. The Discussion suggests that topical permethrin has some repellent activity beyond its insecticidal action, but does not distinguish spatial repellency from contact irritancy. The clause about excitorepellency on clothing follows the citation and is not assessed as a claim attributed to this source. (LLM, conf=0.86)
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Research works printed but not linked: 12
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Cited by
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Bowman, N. M., Akialis, K., Cave, G., Barrera, R., Apperson, C. S., & Meshnick, S. R. (2018) · PLoS ONE · doi:10.1371/journal.pone.0196410 · Cited by 72
Metadata
- Authors
- Miot, H. A., Ferreira, D. P., Mendes, F. G., Carrenho, F. R. H., Amui, I. D. O., Carneiro, C. A. S., & Madeira, N. G.
- ORCID
- Miot, Hélio Amante
- Venue
- Dermatology Online Journal
- Publisher
- California Digital Library (CDL)
- Published
- 2008-07-01
- Volume
- 14
- Issue
- 7
- Pages
- 1-1
- ISSN
- 1087-2108 (ISSN-L)
- OpenAlex
- W157453423
- Cited by
- 8
- References
- 0
- Citations by year
- 2020: 2 · 2019: 1 · 2018: 1 · 2016: 1 · 2013: 1 · 2012: 1
- FWCI
- 0.22
- Type
- journal article
- Language
- en
- Open access
- green
- escholarship.org
- Licence
- other-oa
- Locations
- Dermatology Online Journal (publishedVersion)
- PubMed (publishedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, other-oa)
- Acervo Digital da Universidade Estadual Paulista (Universidade Estadual Paulista) (submittedVersion, other-oa)
- Americanae (AECID Library) (submittedVersion, cc-by-nc-nd)
- eScholarship (California Digital Library) (submittedVersion, cc-by-nc-nd)
- PubMed
- Topics
- Health Sciences › Medicine › Infectious Diseases › Dermatological diseases and infestations
- Life Sciences › Immunology and Microbiology › Parasitology › Vector-borne infectious diseases
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Insect Pest Control Strategies
- Keywords
- tick repellents, tick bites, tick-borne diseases, repellent efficacy
- MeSH terms
- Aedes, Animals, Brazil, DEET, Female, Humans, Insect Bites and Stings, Insect Repellents, Mosquito Control, Probability, Reference Values, Sensitivity and Specificity, Time Factors, Cohort Studies, Permethrin
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