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Topical proactive therapy in dermatology. A scoping review
Open accessAbstract
The term 'proactive therapy' refers to a long-term management of clinically intact skin in previously disease-affected areas. This method was initially implemented in atopic dermatitis to maintain the remission and decrease the risk of exacerbations. Proactive therapy aims to limit the need for reactive treatment and improve the patients' quality of life. A proactive approach is likely to be adopted for other relapsing and inflammatory skin conditions in the future. This scoping review aims to identify dermatological conditions to be treated with the proactive approach, evaluate the available evidence for its efficacy and safety, as well as highlight the research gaps.
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“In cases with controlled disease (i.e., with subclinical inflammation), exposure to irritants, dust, detergents, and hot baths/showers in winter are elements recognized as triggers of clinical recurrence, which reinforces the importance of maintaining therapies aimed at recovering the skin barrier and proactive strategies to prolong AD clinical remission.”
From Update on the pathogenesis of atopic dermatitis. (2024) · cites this paper as [58]
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“In general, the deficit in the skin barrier in AD is an important component of allergic sensitization in these patients, and also a relevant factor in disease exacerbations.”
From Update on the pathogenesis of atopic dermatitis. (2024) · cites this paper as [58]
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The PRISMA 2020 statement: An updated guideline for reporting systematic reviews
Page, M. J., McKenzie, J. E., Bossuyt, P. M., Boutron, I., Hoffmann, T. C., Mulrow, C. D., Shamseer, L., Tetzlaff, J. M., Akl, E. A., Brennan, S. E., et al. (2021) · BMJ · doi:10.1136/bmj.n71 · Cited by 108,283
PRISMA Extension for Scoping Reviews (PRISMA-ScR): Checklist and Explanation
Tricco, A. C., Lillie, E., Zarin, W., O'Brien, K. K., Colquhoun, H., Levac, D., Moher, D., Peters, M. D. J., Horsley, T., Weeks, L., et al. (2018) · Annals of Internal Medicine · doi:10.7326/m18-0850 · Cited by 43,565
Munn, Z., Peters, M. D. J., Stern, C., Tufanaru, C., McArthur, A., & Aromataris, E. (2018) · BMC Medical Research Methodology · doi:10.1186/s12874-018-0611-x · Cited by 11,385
Schmitt, J., von Kobyletzki, L., Svensson, Å., & Apfelbacher, C. (2011) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2010.10030.x · Cited by 257 · cited 2×
“[14] conducted a meta-analysis of eight randomized controlled trials (RCTs) that included four studies of topical 0.”
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Research works printed but not linked: 64
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Cited by
Update on the pathogenesis of atopic dermatitis.
Criado, P. R., Miot, H. A., Bueno-Filho, R., Ianhez, M., Criado, R. F. J., & de Castro, C. C. S. (2024) · Anais brasileiros de dermatologia · doi:10.1016/j.abd.2024.06.001 · Cited by 66
Metadata
- Authors
- Makowska, K., Nowaczyk, J., Samochocki, Z., Blicharz, L., & Rudnicka, L.
- Affiliations
- Medical University of Warsaw (PL)
- Corresponding author
- Blicharz, Leszek
- Venue
- Advances in Dermatology and Allergology
- Publisher
- Termedia Sp. z.o.o.
- Published
- 2023
- Volume
- 40
- Issue
- 4
- Pages
- 510-517
- ISSN
- 0860-6218 (ISSN-L)
- 1642-395X
- PMC
- PMC10485751
- OpenAlex
- W4386381999
- Cited by
- 10
- References
- 4
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 5
- FWCI
- 0.46
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Advances in Dermatology and Allergology (publishedVersion)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Health Sciences › Medicine › Dermatology › Contact Dermatitis and Allergies
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Keywords
- proactive therapy, topical treatment, atopic dermatitis, inflammatory skin diseases, remission, quality of life, treatment efficacy and safety
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