The DOI matches its Crossref record, with a small difference in title or year; 29 of the 30 references it cites were found in a registry or an index.
Assessment of the response to gluten-free diet in an Iraqi population with coeliac disease. A histological and serological follow-up study
Open accessAbstract
INTRODUCTION: Coeliac disease (CD) is a common diagnosis among children and adults in Iraq; however, removal of gluten from the diet is essential for patients with CD. The aim of this study, the first such study in Iraq, was to assess the serological and histological recovery profiles of coeliac patients, in both children and adults groups after commencing a gluten-free diet (GFD) for at least 1 year ± 1 month. MATERIAL AND METHODS: The study group comprised 78 proved coeliac patients (46 children and 32 adults, median age: 15 years, range: 1-66 years) who all agreed to undergo endoscopy in addition to serological assessment before and after treatment. The duodenal biopsies were interpreted histologically according to modified Marsh criteria and the sera were tested for anti-gliadin antibody (AGA), endomysium antibody (EMA) and anti-tissue transglutaminase antibody (tTG). RESULTS: Complete histological remission was seen in 29 (63.1%) of 46 treated children CD patients, while only 5 (10.9%) showed Marsh IIIa changes compared with 11 (24%) before GFD. Similarly none of the 32 adults after GFD showed Marsh IIIb and Marsh IIIc compared with 46.9% and 28.1% before treatment respectively (p = 001). Meanwhile, there was strongly significant reduction in AGA, EMA, and tTG antibodies levels (p = 0.00001) following GFD. CONCLUSIONS: Repeating the duodenal biopsy 1 year ±1 month after diagnosis and starting a GFD supports the routine measurement of using histological findings as a gold standard test to confirm recovery of Iraqi CD patients along with using known coeliac serology antibodies.
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“In the scarce literature regarding persisting villous atrophy in CD children on a GFD, we found a prevalence of 2%-19% at 1-3 years after CD diagnosis (75, 85-89).”
From ESPGHAN Position Paper on Management and Follow-up of Children and Adolescents With Celiac Disease. (2022) · cites this paper as [89]
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Citations
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Research works printed but not linked: 1
- [15]Osman MT Broad look to coeliac disease in Iraq 2004 Baghdad University of Baghdad A PhD thesis in Pathology
Cited by
ESPGHAN Position Paper on Management and Follow-up of Children and Adolescents With Celiac Disease.
Mearin, M. L., Agardh, D., Antunes, H., Al‐toma, A., Auricchio, R., Castillejo, G., Catassi, C., Ciacci, C., Discepolo, V., Dolinsek, J., et al. (2022) · Journal of pediatric gastroenterology and nutrition · doi:10.1097/mpg.0000000000003540 · Cited by 186
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Cheng, F. W., & Handu, D. (2020) · Journal of the Academy of Nutrition and Dietetics · doi:10.1016/j.jand.2019.09.019 · Cited by 10
Metadata
- Authors
- Osman, M., Taha, B., & Duboni, G. A.
- Affiliations
- National Defence University of Malaysia (MY)
- Baghdad Medical City (IQ)
- Corresponding author
- Osman, Muhamed
- ORCID
- Osman, Muhamed
- Venue
- Archives of Medical Science
- Publisher
- Termedia Sp. z.o.o.
- Published
- 2014
- Volume
- 2
- Issue
- 2
- Pages
- 294-299
- ISSN
- 1734-1922 (ISSN-L)
- PMC
- PMC4042032
- OpenAlex
- W1983493088
- Cited by
- 9
- References
- 30
- Citations by year
- 2026: 1 · 2025: 1 · 2022: 1 · 2021: 1 · 2020: 2 · 2019: 1 · 2018: 1 · 2016: 1
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc-sa
- Locations
- Archives of Medical Science (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Gastroenterology › Celiac Disease Research and Management
- Health Sciences › Medicine › Gastroenterology › Eosinophilic Esophagitis
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Wheat and Barley Genetics and Pathology
- Keywords
- celiac disease, gluten-free diet, duodenal biopsy, histological remission, anti-tissue transglutaminase antibodies, anti-gliadin antibodies, anti-endomysial antibodies, serological response, children and adults, Iraqi population
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