Clinical importance of epicardial adipose tissue
Open accessAbstract
Different visceral fat compartments have several systemic effects and may play a role in the development of both insulin resistance and cardiovascular diseases. In the last couple of years special attention has been paid to the epicardial adipose tissue (EAT), which can be quantified by non-invasive cardiac imaging techniques. The epicardial fat is a unique fat compartment between the myocardium and the visceral pericardium sharing a common embryologic origin with the visceral fat depot. Epicardial adipose tissue has several specific roles, and its local effects on cardiac function are incorporated in the complex pathomechanism of coronary artery disease. Importantly, EAT may produce several adipocytokines and chemokines that may influence - through paracrine and vasocrine effects - the development and progression of coronary atherosclerosis. Epicardial adipose tissue volume has a relatively strong genetic dependence, similarly to other visceral fat depots. In this article, the anatomical and physiological as well as pathophysiological characteristics of the epicardial fat compartment are reviewed.
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EAT provides FAs directly to myocardium at times of high energy demand and implements local triacylglycerol storage as request decreases.
“To that end, EAT provides FAs directly to myocardium at times of high energy demand and implements the local triacylglycerol storage as request decreases [34,35].”
From Dysregulated epicardial adipose tissue as a risk factor and potential therapeutic target of heart failure with preserved ejection fraction in diabetes (2022) · cites this paper as [35]
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References 90 · Cited by 121
Research works printed but not linked: 4
- [22]Gorter PM van Lindert AS de Vos AM Quantification of epicardial and peri-coronary fat using cardiac computed tomography; reproducibility and relation with obesity and metabolic syndrome in patients suspected of coronary artery disease Atherosclerosis 2008 197 896 903 17884060
- [27]Iacobellis G Bianco AC Epicardial adipose tissue: emerging physiological, pathophysiological and clinical features Trends Endocrinol Metab 2011 22 450 7 21852149 PMC4978122
- [39]Sacks HS Fain JN Human epicardial adipose tissue: a review Am Heart J 2007 153 907 17 17540190
- [81]Lim S Meigs JB Links between ectopic fat and vascular disease in humans Arterioscler Thromb Vasc Biol 2014 34 1820 6 25035342 PMC4140970
- Authors
- Nagy, E., Jermendy, A. L., Merkely, B., & Maurovich-Horvat, P.
- Affiliations
- Semmelweis University (HU)
- ORCID
- Nagy, Eszter
- Venue
- Archives of Medical Science
- Publisher
- Termedia Sp. z.o.o.
- Published
- 2017
- Volume
- 4
- Issue
- 4
- Pages
- 864-874
- ISSN
- 1734-1922 (ISSN-L)
- PMC
- PMC5507110
- OpenAlex
- W2545736093
- Cited by
- 121
- References
- 90
- Citations by year
- 2026: 3 · 2025: 10 · 2024: 9 · 2023: 8 · 2022: 21 · 2021: 18 · 2020: 26 · 2019: 12 · 2018: 10 · 2017: 3
- FWCI
- 6.86
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc-sa
- Locations
- Archives of Medical Science (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- Semmelweis University Repository (Semmelweis University) (submittedVersion)
- Funders
- European Foundation for the Study of Diabetes
- Semmelweis Egyetem
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Pericarditis and Cardiac Tamponade
- Keywords
- epicardial adipose tissue, visceral fat, coronary artery disease, atherosclerosis, insulin resistance, adipokines, chemokines, paracrine signaling, cardiac imaging, cardiovascular risk
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