Centella asiatica in cosmetology
Open accessAbstract
Centella asiatica known as Gotu Kola is a medicinal plant that has been used in folk medicine for hundreds of years as well as in scientifically oriented medicine. The active compounds include pentacyclic triterpenes, mainly asiaticoside, madecassoside, asiatic and madecassic acids. Centella asiatica is effective in improving treatment of small wounds, hypertrophic wounds as well as burns, psoriasis and scleroderma. The mechanism of action involves promoting fibroblast proliferation and increasing the synthesis of collagen and intracellular fibronectin content and also improvement of the tensile strength of newly formed skin as well as inhibiting the inflammatory phase of hypertrophic scars and keloids. Research results indicate that it can be used in the treatment of photoaging skin, cellulite and striae.
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Topical treatments using madecassoside and asiaticoside improve cellulite and striae.
“Topical treatments using madecassoside 87 and asiaticoside. 88 , 89 show improvements in hyperpigmentation, 88 , 90 photoaging skin, cellulite and striae 91 and periocular wrinkles. 87 , 89 , 92”
From Therapeutic Properties and Pharmacological Activities of Asiaticoside and Madecassoside: A Review (2023) · cites this paper as [91]
The Biological activity section reports improved skin condition after topical Madecassol® use in people with cellulite and fewer, less severe striae after use of a cream containing Centella asiatica extract. It does not establish that topical madecassoside or asiaticoside specifically produced those effects; the striae cream also contained other ingredients. No page numbers are available in our copy. (LLM, conf=0.86)
Experimental — accuracy not yet measuredClinical evidence supporting the efficacy of orally administered Centella asiatica for skin health remains limited.
“Despite these promising mechanistic findings, clinical evidence supporting the efficacy of orally administered Centella asiatica for skin health remains limited [28,29].”
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References 29 · Cited by 229
Research works printed but not linked: 1
- [13]Barnes J Anderson LA Philipson JD Herbal medicines 2007 3rd ed London Pharmaceutical Press
- Authors
- Bylka, W., Znajdek-Awiżeń, P., Studzińska-Sroka, E., & Brzezińska, M.
- Affiliations
- Poznan University of Medical Sciences (PL)
- Corresponding author
- Bylka, Wiesława
- Venue
- Advances in Dermatology and Allergology
- Publisher
- Termedia Sp. z.o.o.
- Published
- 2013
- Volume
- 1
- Issue
- 1
- Pages
- 46-49
- ISSN
- 0860-6218 (ISSN-L)
- 1642-395X
- PMC
- PMC3834700
- OpenAlex
- W1968141753
- Cited by
- 229
- References
- 29
- Citations by year
- 2026: 18 · 2025: 22 · 2024: 28 · 2023: 40 · 2022: 29 · 2021: 29 · 2020: 14 · 2019: 12 · 2018: 12 · 2017: 11 · 2016: 8 · 2015: 2 · 2014: 3 · 2013: 1
- FWCI
- 5.40
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Advances in Dermatology and Allergology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Health Sciences › Medicine › Dermatology › Dermatologic Treatments and Research
- Keywords
- Centella asiatica, medicinal plants, pentacyclic triterpenes, asiaticoside, madecassoside, asiatic acid, madecassic acid, wound healing, hypertrophic scars, keloids, psoriasis, systemic sclerosis, burns, collagen synthesis, fibronectin, cellulite, striae, cosmetic applications
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